incidental findings

偶然发现
  • 文章类型: Case Reports
    心脏肿块包括广泛的病变,其性质可能既是肿瘤性(原发性和继发性)也不是。在这里,我们报告了一例53岁的女性,该女性转诊到我们的中心进行磁共振胰腺病变随访。右心房圆形病变的侧支发现,在腹部检查期间,导致进一步的诊断调查。通过非参数和参数序列进行心血管磁共振来解决鉴别诊断,允许右心房血栓的定义。据我们所知,文献中没有关于通过腹部磁共振偶然诊断心脏血栓的数据。此案例强调了图像评估对偶然发现的重要性,进一步证明了在CMR表征后启动图像引导治疗的可行性。
    Cardiac masses include a wide range of lesions whose nature could be both neoplastic (primary and secondary) or not. Here we report the case of a 53-year-old woman referred to our center for pancreatic lesion follow up by magnetic resonance. The collateral finding of a rounded-shaped lesion in the right heart atrium, during the abdomen examination, led to further diagnostic investigation. Cardiovascular magnetic resonance by nonparametric and parametric sequences was performed to settle the differential diagnosis, allowing for the definition of right atrial thrombus. At the best of our knowledge no data are available in literature about the incidental diagnosis of cardiac thrombi through abdominal magnetic resonance. This case underlines the importance of image evaluation for incidental findings, further demonstrating the feasibility of initiating an image-guided therapy after a characterization by CMR.
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  • 文章类型: Case Reports
    背景:原发性肺血管肉瘤(PPA)是一种高度侵袭性和罕见的恶性肿瘤,起源于肺部血管的内皮细胞。PPA是一种极为罕见的亚型,迄今报告的病例不到30例。PPA不仅诊断具有挑战性,而且预后不良。通常导致诊断后一年内的高死亡率,不管治疗方法如何。
    方法:我们介绍一例33岁女性,无明显既往病史,表现为腹痛,偶然发现右侧肺门肿块伴胸腔积液和脓胸。胃溃疡穿孔手术后,她的肺部病变被进一步处理。尽管进行了广泛的诊断评估,包括成像,支气管镜检查,开胸手术,建立诊断是具有挑战性的。最终,在外科肺活检中诊断出PPA,患者开始接受帕唑帕尼和紫杉醇化疗,但由于多种并发症,1个月后过期。
    结论:该病例突出了诊断这种罕见肿瘤的困难和无论如何治疗的不良预后。需要提高对PPA的认识和更多的研究,以改善这种致命疾病的早期发现和治疗选择。
    BACKGROUND: Primary pulmonary angiosarcoma (PPA) is a highly aggressive and rare malignancy originating from the endothelial cells of blood vessels in the lungs. PPA is an extremely rare subtype, with less than 30 cases reported to date. PPA is not only challenging to diagnose but also has a poor prognosis, often resulting in a high mortality rate within a year of diagnosis, regardless of the treatment approach.
    METHODS: We present the case of a 33-year-old woman with no significant past medical history who presented with abdominal pain and was incidentally found to have a right hilar mass with pleural effusion and empyema. After undergoing surgery for a perforated gastric ulcer, her pulmonary lesions were further worked up. Despite an extensive diagnostic evaluation, including imaging, bronchoscopy, and thoracotomy, establishing a diagnosis was challenging. Ultimately, PPA was diagnosed on surgical lung biopsy, and the patient was started on pazopanib and paclitaxel chemotherapy but expired after 1 month due to multiple complications.
    CONCLUSIONS: This case highlights the difficulty in diagnosing this rare tumor and its poor prognosis regardless of therapy. Greater awareness of PPA and more research are needed to improve early detection and treatment options for this deadly disease.
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  • 文章类型: Case Reports
    结肠髂内动脉瘤破裂是一种罕见但可能致命的并发症。我们报告了在医学检查中偶然发现的无症状内动脉瘤的直肠瘘。一名77岁的男子出现在当地一家医院接受一般体检。虽然血液报告显示严重贫血,患者没有抱怨任何相关症状,包括头晕和便血。此外,病人的腹部没有明显的肿块,没有便血的证据,因为病人一直在使用坐浴盆。有趣的是,计算机断层扫描(CT)显示右侧髂内动脉瘤。CT中有一个可疑的结肠瘘管,但在术前乙状结肠镜检查中没有发现。此外,手术发现显示突出的腹膜后肿块粘附在乙状结肠的肠系膜上。在动脉瘤切除期间,瘘管的存在尚不清楚。然而,瘘管道,没有任何传染性细菌,如肺结核,在结肠切除后的标本中发现。经过大约一周的恢复期,患者出院,术后CT无任何异常发现.由髂动脉瘤引起的乙状结肠瘘很少见。此外,在患者常规使用坐浴盆的特殊情况下,诊断可能会延迟。
    The rupture of an internal iliac artery aneurysm in the colon is a rare but potentially fatal complication. We report a rectal fistula of an asymptomatic internal iliac artery aneurysm that was discovered incidentally during a medical examination. A 77-year-old man presented at a local hospital for a general medical examination. Although the blood reports revealed severe anemia, the patient did not complain of any associated symptoms including dizziness and hematochezia. Moreover, there was no palpable mass in the patient\'s abdomen, and there was no evidence of hematochezia, as the patient had been using a bidet. Interestingly, computed tomography (CT) revealed a large right internal iliac artery aneurysm. There was a suspicious finding of a fistula within the colon in the CT, but it was undetected in the preoperative sigmoidoscopy. Furthermore, operative findings showed a protruding retroperitoneal mass adhering to the mesentery of the sigmoid colon. During aneurysm resection, the presence of a fistula was unclear. However, a fistula tract, devoid of any infectious bacteria such as tuberculosis, was found in the specimen after colon resection. After a recovery period of approximately one week, the patient was discharged from the hospital without any unusual findings on the post-operative CT. Sigmoid colonic fistulas arising from iliac artery aneurysms are rare. Also, diagnosis may be delayed in special circumstances wherein a patient routinely uses a bidet.
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  • 文章类型: Journal Article
    虽然用于肺癌筛查(LCS)的低剂量计算机断层扫描(LDCT)因其在降低肺癌死亡率方面的有效性而得到认可,它通常同时导致检测到与主要筛查指征无关的偶然发现(IFs).这些IF提出了诊断和管理挑战,可能导致患者不必要的焦虑和进一步的侵入性诊断程序。这篇综述文章概述了LDCT中遇到的IFs,强调其临床意义和推荐的管理策略。我们根据它们的解剖位置对IFs进行分类(胸内-肺内,胸内-肺外,和胸腔外),并讨论最常见的发现。我们强调了利用美国放射学会(ACR)的指南和标准化报告系统来指导适当随访的重要性。对于每个类别,我们给出了具体的IF例子,他们的放射学特征,以及建议的管理方法。这篇综述旨在为放射科医生和临床医生提供对LCS中IFs的全面了解,以便进行准确的评估和管理,最终加强患者护理。最后,我们概述了管理IFs的未来研究和发展的几个关键方面。
    While low-dose computed tomography (LDCT) for lung cancer screening (LCS) has been recognized for its effectiveness in reducing lung cancer mortality, it often simultaneously leads to the detection of incidental findings (IFs) unrelated to the primary screening indication. These IFs present diagnostic and management challenges, potentially causing unnecessary anxiety and further invasive diagnostic procedures for patients. This review article provides an overview of IFs encountered in LDCT, emphasizing their clinical significance and recommended management strategies. We categorize IFs based on their anatomical locations (intrathoracic-intrapulmonary, intrathoracic-extrapulmonary, and extrathoracic) and discuss the most common findings. We highlight the importance of utilizing guidelines and standardized reporting systems by the American College of Radiology (ACR) to guide appropriate follow-ups. For each category, we present specific IF examples, their radiologic features, and the suggested management approach. This review aims to provide radiologists and clinicians with a comprehensive understanding of IFs in LCS for accurate assessment and management, ultimately enhancing patient care. Finally, we outline a few key aspects for future research and development in managing IFs.
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  • 文章类型: Journal Article
    背景:纤维样型纤维瘤病(DTF),也被称为侵袭性纤维瘤病,是一种罕见的肿瘤,起源于筋膜或肌膜膜组织。虽然是良性的,以缓慢的生长为特征,它表现出局部侵袭性,缺乏特定的临床特征。然而,在相当比例的患者中,它可能无症状,并在常规临床检查中意外发现。医学文献中只报道了少数由腰大肌引起的DTF病例。
    方法:一名24岁男性,无症状且无明显的个人或家族病史,在常规体检中通过腹部超声检查诊断为2级肾积水。此诊断是在进行简单的心脏直视手术以修复房间隔缺损15天后做出的。
    方法:静脉肾盂造影显示肾积水伴骨盆管系统扩张。输尿管镜检查排除了输尿管的任何内在病变。对比增强计算机断层扫描发现腹膜后有3.5×2×5.2cm肿块,与腰大肌密切相关,并包围与髂动脉相邻的输尿管。术后病理分析证实了散发性DTF的明确诊断。
    方法:患者接受腹部探查手术,在此期间切除肿瘤,没有任何术中并发症。
    结果:经过5年的密切监测,其中包括定期体检,磁共振成像,和超声检查,未发现局部复发.
    结论:在涉及源自腰大肌并包裹输尿管的腹膜后肿瘤的病例中,实现准确的术前诊断是一个挑战。然而,双J支架的插入被认为是手术过程中的关键步骤,促进输尿管与肿瘤的解剖和隔离,同时保留肾功能。
    BACKGROUND: Desmoid-type fibromatosis (DTF), also known as aggressive fibromatosis, is a rare neoplasm originating from the fascial or musculoaponeurotic tissues. While benign and characterized by slow growth, it exhibits local aggressiveness and lacks specific clinical characteristics. However, in a considerable percentage of patients, it could be asymptomatic and discovered by accident during routine clinical examinations. Only a few cases of DTF arising from the psoas major muscle have been reported in the medical literature.
    METHODS: A 24-year-old male, asymptomatic and without significant personal or family medical history, was diagnosed with grade 2 hydronephrosis by abdominal ultrasonography during a routine physical examination. This diagnosis was made 15 days after undergoing uncomplicated open-heart surgery to repair an atrial septal defect.
    METHODS: Intravenous pyelogram revealed hydronephrosis with dilation of the pelvicalyceal system. Ureteroscopy ruled out any intrinsic lesions of the ureter. Contrast-enhanced computed tomography identified a 3.5 × 2 × 5.2 cm mass in the retroperitoneum, closely associated with the psoas muscle and enveloping the ureter adjacent to the iliac artery. Postoperative pathological analysis confirmed a definitive diagnosis of sporadic DTF.
    METHODS: The patient underwent exploratory abdominal surgery, during which the tumor was resected without any intraoperative complications.
    RESULTS: After close monitoring over a 5-year follow-up period, which included periodic physical examinations, magnetic resonance imaging, and ultrasonography, no local recurrence was detected.
    CONCLUSIONS: Achieving an accurate preoperative diagnosis presents a challenge in cases involving retroperitoneal tumors originating from the psoas major muscle and encasing the ureter. However, the insertion of a double J stent is deemed a crucial step in the surgical process, facilitating the dissection and isolation of the ureter from the tumor while preserving kidney function.
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  • 文章类型: Case Reports
    背景:甲状旁腺癌(PC)是一种罕见的恶性肿瘤,常通过术后病理检查偶然诊断。结节性甲状腺肿的发生,甲状腺内甲状旁腺癌,对侧甲状旁腺腺瘤(PA),甲状腺乳头状微小癌(PTMC)极为罕见,这促使我们报告我们的案例经验。
    方法:我们描述了一位67岁的男性,他表现为颈部肿块导致气管压迫,这促使他寻求医疗建议。根据彩色多普勒超声的术前辅助检查结果,SPECT甲状旁腺显像,还有血液测试,他最初被诊断为疑似甲状旁腺腺瘤和结节性甲状腺肿。甲状腺右叶和峡部切除术,左上甲状旁腺进行了检查,术中冰冻病理检查。术中观察,发现甲状腺右叶周围粘连。因此,由于怀疑侵袭性恶性肿瘤,进行了右中央区淋巴结清扫术。组织学和免疫组织化学分析显示偶见甲状腺内甲状旁腺癌,对侧甲状旁腺腺瘤,经典甲状腺乳头状微小癌,结节性甲状腺肿.
    结论:当出现极高水平的PTH和严重的高钙血症时,应高度怀疑甲状旁腺癌。这不能简单地用术前局部甲状旁腺腺瘤来解释,尤其是术中探查发现可疑恶性粘连时。在多灶性甲状腺结节与99Tc-sestamibi摄取增加相关的情况下,应该考虑共存癌的可能性,不仅适用于甲状腺恶性肿瘤,还可能存在甲状腺内甲状旁腺癌。
    BACKGROUND: Parathyroid carcinoma (PC) is a rare malignancy, often diagnosed incidentally through postoperative pathological examination. The occurrence of nodular goiter, intrathyroidal parathyroid carcinoma, contralateral parathyroid adenoma (PA), and papillary thyroid microcarcinoma (PTMC) is extremely uncommon, which prompted us to report our case experience.
    METHODS: We describe a 67-year-old male who presented with a cervical mass causing tracheal compression, which prompted him to seek medical advice. Based on preoperative auxiliary examination results from color Doppler ultrasound, SPECT parathyroid imaging, and blood tests, he was initially diagnosed with a suspected parathyroid adenoma and nodular goiter. Excision of the right lobe and isthmus of the thyroid, and left superior parathyroid gland was conducted, which were sent to intraoperative frozen pathological examination. During intraoperative observation, adhesion around the right thyroid lobe was discovered. Consequently, right central area lymph node dissection was performed due to suspicion of an aggressive malignant tumor. Histology and immunohistochemistry analysis revealed incidental intrathyroidal parathyroid carcinoma, contralateral parathyroid adenoma, classical papillary thyroid microcarcinoma, and nodular goiter.
    CONCLUSIONS: Parathyroid carcinoma should be highly suspected when extremely high levels of PTH and severe hypercalcemia are present, which cannot be simply explained by a preoperatively localized parathyroid adenoma, especially when suspicious malignant adhesion is found during intraoperative exploration. In cases where multifocal thyroid nodules are associated with increased uptake of 99Tc-sestamibi, the possibility of coexisting carcinomas should be considered, not only for thyroid malignancy but also for the potential presence of intrathyroidal parathyroid carcinoma.
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  • 文章类型: Systematic Review
    目的:本系统综述旨在探讨核成像技术在检测偶发瘤中的作用及其对患者管理的影响。
    方法:遵循PRISMA指南,从2022年2月至5月进行了全面的文献检索.包括英语研究,涉及接受核医学研究并附带肿瘤发现的患者。成像模式数据,偶发瘤的特点,管理变革,并进行随访分析。
    结果:纳入92项研究,涉及64.884例患者。611例(0.9%)检出偶发瘤,甲状腺是最常见的部位。使用FDG和胆碱示踪剂的PET/CT显示出最高的偶发瘤检出率。发现偶发瘤导致59%的病例改变了治疗策略。各种放射性示踪剂对偶发瘤检测表现出高灵敏度,特别是神经内分泌肿瘤和前列腺癌。
    结论:核成像技术在检测偶发瘤中起着至关重要的作用,导致患者管理的重大变化。这些模式的高灵敏度凸显了它们在常规肿瘤学随访方案中的潜力。未来的方向可能包括提高空间分辨率和促进治疗方法,以改善患者护理。
    OBJECTIVE: This systematic review aims to investigate the role of nuclear imaging techniques in detecting incidentalomas and their impact on patient management.
    METHODS: Following PRISMA guidelines, a comprehensive literature search was conducted from February to May 2022. Studies in English involving patients undergoing nuclear medicine studies with incidental tumor findings were included. Data on imaging modalities, incidentaloma characteristics, management changes, and follow-up were extracted and analyzed.
    RESULTS: Ninety-two studies involving 64.884 patients were included. Incidentalomas were detected in 611 cases (0.9%), with thyroid being the most common site. PET/CT with FDG and choline tracers showed the highest incidentaloma detection rates. Detection of incidentalomas led to a change in therapeutic strategy in 59% of cases. Various radiotracers demonstrated high sensitivity for incidentaloma detection, particularly in neuroendocrine tumors and prostate cancer.
    CONCLUSIONS: Nuclear imaging techniques play a crucial role in detecting incidentalomas, leading to significant changes in patient management. The high sensitivity of these modalities highlights their potential in routine oncology follow-up protocols. Future directions may include enhancing spatial resolution and promoting theranostic approaches for improved patient care.
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  • 文章类型: Journal Article
    由于放射摄影成像技术的广泛使用,肾上腺肿瘤的发病率正在增加。肿瘤大小等因素,放射学特征,肾上腺腺瘤的功能在诊断和后续治疗中起着至关重要的作用。在这项回顾性研究中,我们调查了临床,放射学,和肾上腺偶发瘤(AI)患者的手术特征,并评估其随访结果。
    我们分析了431名诊断为AI的患者(130名男性,301名女性)在我们中心接受了肾上腺激素评估。我们在放射学特征方面比较了无功能和有功能的AI。我们还比较了无功能AI的基线和随访特征。
    患者的平均年龄为55.4±11.5岁,平均肿瘤大小为25.9±14.3mm。平均随访时间为3.17±2.07年。腺瘤定位显示165(38.3%)右侧,185(42.9%)左侧,81例(18.8%)双侧病例。大多数患者(76.6%)患有无功能的AI。随访期间,无功能的AI表现出空腹血糖升高,空腹胰岛素和HOMA-IR值(分别为p=0.002,<0.001和0.004)。在正常运作的AIs案例(23.4%)中,自主皮质醇分泌,库欣综合征,嗜铬细胞瘤,原发性醛固酮增多率为10.4%,5.1%,3.9%,3.9%的病例,分别。受试者工作特征曲线分析确定了26.5mm大小的肾上腺腺瘤作为区分功能性和非功能性AI的最佳界限。敏感性和特异性分别为61.4%和70.0%,分别。
    尽管大多数AI都不起作用,功能性肾上腺腺瘤的患病率并不罕见.我们的发现表明,腺瘤的大小是早期发现功能性腺瘤的有价值的预测指标。此外,较小的肿块似乎具有较低的恶性肿瘤风险。
    UNASSIGNED: The incidence of adrenal tumors is increasing due to the widespread utilization of radiographic imaging techniques. Factors such as tumor size, radiological characteristics, and functionality of adrenal adenomas play crucial roles in diagnosis and subsequent management. In this retrospective study, we investigated the clinical, radiological, and surgical features of patients with adrenal incidentalomas (AIs) and evaluated their follow-up results.
    UNASSIGNED: We analyzed data from 431 patients diagnosed with AIs (130 males, 301 females) who underwent adrenal hormone evaluation at our center. We compared nonfunctioning and functioning AIs in terms of radiological features. We also compared baseline and follow-up characteristics in nonfunctioning AIs.
    UNASSIGNED: The mean age of the patients was 55.4 ± 11.5 years, with a mean tumor size of 25.9 ± 14.3 mm. Mean follow-up duration was 3.17 ± 2.07 years. Adenoma localization revealed 165 (38.3%) right-sided, 185 (42.9%) left-sided, and 81 (18.8%) bilateral cases. Most patients (76.6%) had nonfunctioning AIs. During follow-up, nonfunctioning AIs exhibited increased fasting blood glucose, fasting insulin and HOMA-IR values (p = 0.002, <0.001 and 0.004, respectively). Among the functioning AIs cases (23.4%), autonomous cortisol secretion, Cushing\'s syndrome, pheochromocytoma, and primary aldosteronism were observed in 10.4%, 5.1%, 3.9%, and 3.9% of cases, respectively. Receiver operating characteristic curve analysis determined an adrenal adenoma size of 26.5 mm as the optimal cut-off for distinguishing between functioning and nonfunctioning AIs, with a sensitivity and specificity of 61.4% and 70.0%, respectively.
    UNASSIGNED: Although the majority of AIs are nonfunctioning, the prevalence of functioning adrenal adenomas is not rare. Our findings suggest that adenoma size emerges as a valuable predictor for early detection of functioning adenomas. In addition, smaller masses appear to carry a lower risk of malignancy.
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  • 文章类型: Case Reports
    背景技术恶性腹膜间皮瘤(MPM)是一种罕见的,浆液性膜的致死性肿瘤。据报道,与MPM相关的最常见因素是石棉暴露,而病毒感染,遗传易感性,副肿瘤综合征,和改变的免疫力也有描述。在肿瘤负担较低以及非特异性症状的患者中,诊断可能具有挑战性。偶然发现诊断并不罕见。病例报告一名患有失代偿期肝硬化的中年女性接受了广泛的移植前检查,没有显示恶性肿瘤的证据.她有石棉暴露的个人病史和大家庭中的MPM家族史。在移植手术中,注意到一些腹膜结节,导致程序终止。病理分析证实为恶性MPM。多学科的讨论导致遵循保守的治疗方法,没有任何干预,由于与腹膜炎切除术和腹膜内化疗相关的肝功能失代偿恶化的风险较高。患者的肝功能失代偿在肝移植手术中止后6个月得到解决。由于MPM的诊断,正电子发射断层扫描显示MPM连续3年没有复发。结论这是在肝移植手术中偶然诊断出的第一例MPM。此病例突出了失代偿性肝病患者MPM的诊断和管理方面的挑战。多学科方法并遵循共识决定导致所述患者的生存期延长。
    BACKGROUND Malignant peritoneal mesothelioma (MPM) is a rare, lethal tumor of serous membranes. The most common factor reported in association with MPM is asbestos exposure, while viral infections, genetic predisposition, paraneoplastic syndrome, and altered immunity have been described as well. The diagnosis can be challenging among those with lower tumor burden as well as nonspecific symptoms, and it is not unusual to discover the diagnosis incidentally. CASE REPORT A middle-aged woman with decompensated cirrhosis underwent extensive pre-transplant workup, showing no evidence of malignancy. She had a personal history of asbestos exposure and family history of MPM in the extended family. During transplant surgery, a few peritoneal nodules were noted, leading to termination of the procedure. Pathological analysis confirmed malignant MPM. A multidisciplinary discussion led to following a conservative treatment approach without any intervention, due to higher risk of worsening hepatic decompensation associated with peritonectomy and intraperitoneal chemotherapy. The patient\'s hepatic decompensation resolved 6 months after the aborted liver transplant operation. Since the diagnosis of MPM, positron emission tomography scans have shown no recurrence of MPM for 3 consecutive years. CONCLUSIONS This is the first case of MPM diagnosed incidentally during a liver transplantation surgery. This case highlights the challenges in the diagnosis and management of MPM in a patient with decompensated liver disease. A multidisciplinary approach and following a consensus decision led to prolonged survival in the described patient.
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  • 文章类型: Journal Article
    UNASSIGNED: To conduct a survey on the use of the term \"interstitial lung abnormalities\" in radiology reports in Brazil, propose an appropriate Portuguese-language translation for the term, and provide a brief review of the literature on the topic.
    UNASSIGNED: A survey was sent via electronic message to various radiologists in Brazil, asking about their familiarity with the term, which translation of the term they use in Portuguese, and whether they use the criteria proposed by the Fleischner Society.
    UNASSIGNED: A total of 163 responses were received, from all regions of Brazil. Although the vast majority (88%) of the respondents stated that they were familiar with the term \"interstitial lung abnormalities\", there was considerable variation regarding the equivalent term they used in Portuguese.
    UNASSIGNED: We suggest that the term \"anormalidades pulmonares intersticiais\" be used in order to standardize radiology reports and disseminate knowledge of these findings in Brazil.
    UNASSIGNED: Fazer um levantamento sobre o uso do termo interstitial lung abnormalities nos laudos radiológicos no Brasil, propor uma tradução para o termo e fazer uma breve revisão sobre o tema.
    UNASSIGNED: Foi enviada uma pesquisa, por meio de mensagem eletrônica, para diversos radiologistas de todo o Brasil, questionando sobre a familiarização com o termo, qual tradução em português utilizam e se usam os critérios propostos pela diretriz da Sociedade Fleischner.
    UNASSIGNED: Foram recebidas 163 respostas de todas as regiões do Brasil e a grande maioria dos radiologistas respondeu estar familiarizado com o termo interstitial lung abnormalities (88%), mas houve grande variação em relação ao termo utilizado como tradução para o português.
    UNASSIGNED: Sugerimos a padronização do termo “anormalidades pulmonares intersticiais”, a fim de uniformizar os relatórios radiológicos e difundir esta entidade no País.
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