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Abstract：
UNASSIGNED: The incidence of adrenal tumors is increasing due to the widespread utilization of radiographic imaging techniques. Factors such as tumor size, radiological characteristics, and functionality of adrenal adenomas play crucial roles in diagnosis and subsequent management. In this retrospective study, we investigated the clinical, radiological, and surgical features of patients with adrenal incidentalomas (AIs) and evaluated their follow-up results.
UNASSIGNED: We analyzed data from 431 patients diagnosed with AIs (130 males, 301 females) who underwent adrenal hormone evaluation at our center. We compared nonfunctioning and functioning AIs in terms of radiological features. We also compared baseline and follow-up characteristics in nonfunctioning AIs.
UNASSIGNED: The mean age of the patients was 55.4 ± 11.5 years, with a mean tumor size of 25.9 ± 14.3 mm. Mean follow-up duration was 3.17 ± 2.07 years. Adenoma localization revealed 165 (38.3%) right-sided, 185 (42.9%) left-sided, and 81 (18.8%) bilateral cases. Most patients (76.6%) had nonfunctioning AIs. During follow-up, nonfunctioning AIs exhibited increased fasting blood glucose, fasting insulin and HOMA-IR values (p = 0.002, <0.001 and 0.004, respectively). Among the functioning AIs cases (23.4%), autonomous cortisol secretion, Cushing\'s syndrome, pheochromocytoma, and primary aldosteronism were observed in 10.4%, 5.1%, 3.9%, and 3.9% of cases, respectively. Receiver operating characteristic curve analysis determined an adrenal adenoma size of 26.5 mm as the optimal cut-off for distinguishing between functioning and nonfunctioning AIs, with a sensitivity and specificity of 61.4% and 70.0%, respectively.
UNASSIGNED: Although the majority of AIs are nonfunctioning, the prevalence of functioning adrenal adenomas is not rare. Our findings suggest that adenoma size emerges as a valuable predictor for early detection of functioning adenomas. In addition, smaller masses appear to carry a lower risk of malignancy.
UNASSIGNED: We analyzed data from 431 patients diagnosed with AIs (130 males, 301 females) who underwent adrenal hormone evaluation at our center. We compared nonfunctioning and functioning AIs in terms of radiological features. We also compared baseline and follow-up characteristics in nonfunctioning AIs.
UNASSIGNED: The mean age of the patients was 55.4 ± 11.5 years, with a mean tumor size of 25.9 ± 14.3 mm. Mean follow-up duration was 3.17 ± 2.07 years. Adenoma localization revealed 165 (38.3%) right-sided, 185 (42.9%) left-sided, and 81 (18.8%) bilateral cases. Most patients (76.6%) had nonfunctioning AIs. During follow-up, nonfunctioning AIs exhibited increased fasting blood glucose, fasting insulin and HOMA-IR values (p = 0.002, <0.001 and 0.004, respectively). Among the functioning AIs cases (23.4%), autonomous cortisol secretion, Cushing\'s syndrome, pheochromocytoma, and primary aldosteronism were observed in 10.4%, 5.1%, 3.9%, and 3.9% of cases, respectively. Receiver operating characteristic curve analysis determined an adrenal adenoma size of 26.5 mm as the optimal cut-off for distinguishing between functioning and nonfunctioning AIs, with a sensitivity and specificity of 61.4% and 70.0%, respectively.
UNASSIGNED: Although the majority of AIs are nonfunctioning, the prevalence of functioning adrenal adenomas is not rare. Our findings suggest that adenoma size emerges as a valuable predictor for early detection of functioning adenomas. In addition, smaller masses appear to carry a lower risk of malignancy.
摘要：
■由于放射摄影成像技术的广泛使用，肾上腺肿瘤的发病率正在增加。肿瘤大小等因素，放射学特征，肾上腺腺瘤的功能在诊断和后续治疗中起着至关重要的作用。在这项回顾性研究中,我们调查了临床，放射学,和肾上腺偶发瘤（AI）患者的手术特征，并评估其随访结果。
■我们分析了431名诊断为AI的患者（130名男性，301名女性）在我们中心接受了肾上腺激素评估。我们在放射学特征方面比较了无功能和有功能的AI。我们还比较了无功能AI的基线和随访特征。
■患者的平均年龄为55.4±11.5岁，平均肿瘤大小为25.9±14.3mm。平均随访时间为3.17±2.07年。腺瘤定位显示165（38.3％）右侧，185（42.9%）左侧，81例（18.8%）双侧病例。大多数患者（76.6％）患有无功能的AI。随访期间,无功能的AI表现出空腹血糖升高，空腹胰岛素和HOMA-IR值（分别为p=0.002，<0.001和0.004）。在正常运作的AIs案例(23.4%)中，自主皮质醇分泌，库欣综合征,嗜铬细胞瘤,原发性醛固酮增多率为10.4%，5.1%,3.9%,3.9%的病例，分别。受试者工作特征曲线分析确定了26.5mm大小的肾上腺腺瘤作为区分功能性和非功能性AI的最佳界限。敏感性和特异性分别为61.4%和70.0%，分别。
■尽管大多数AI都不起作用，功能性肾上腺腺瘤的患病率并不罕见.我们的发现表明，腺瘤的大小是早期发现功能性腺瘤的有价值的预测指标。此外,较小的肿块似乎具有较低的恶性肿瘤风险。
■我们分析了431名诊断为AI的患者（130名男性，301名女性）在我们中心接受了肾上腺激素评估。我们在放射学特征方面比较了无功能和有功能的AI。我们还比较了无功能AI的基线和随访特征。
■患者的平均年龄为55.4±11.5岁，平均肿瘤大小为25.9±14.3mm。平均随访时间为3.17±2.07年。腺瘤定位显示165（38.3％）右侧，185（42.9%）左侧，81例（18.8%）双侧病例。大多数患者（76.6％）患有无功能的AI。随访期间,无功能的AI表现出空腹血糖升高，空腹胰岛素和HOMA-IR值（分别为p=0.002，<0.001和0.004）。在正常运作的AIs案例(23.4%)中，自主皮质醇分泌，库欣综合征,嗜铬细胞瘤,原发性醛固酮增多率为10.4%，5.1%,3.9%,3.9%的病例，分别。受试者工作特征曲线分析确定了26.5mm大小的肾上腺腺瘤作为区分功能性和非功能性AI的最佳界限。敏感性和特异性分别为61.4%和70.0%，分别。
■尽管大多数AI都不起作用，功能性肾上腺腺瘤的患病率并不罕见.我们的发现表明，腺瘤的大小是早期发现功能性腺瘤的有价值的预测指标。此外,较小的肿块似乎具有较低的恶性肿瘤风险。
