荟萃分析旨在评估高压氧治疗对糖尿病足溃疡的影响。使用二分法或有争议的随机或固定效应模型,我们检查了这项荟萃分析的结局,并计算了比值比(OR)和均差(MD)以及95%置信区间(CIs).1992年至2022年的17项检查被纳入本荟萃分析,包括7219名糖尿病足溃疡患者.高压氧治疗有明显较高的愈合性溃疡(OR,14.39;95%CI,4.02-51.52,p<0.001),较高的不良事件(或,2.14;95%CI,1.11-4.11,p=0.02),较低的死亡率(或,0.22;95%CI,0.07-0.71,p=0.01)和更高的溃疡面积减少(MD,23.39;95%CI,11.79-34.99,p<0.001)与糖尿病足溃疡患者的标准治疗相比。然而,高压氧治疗和标准治疗在截肢方面没有显着差异(OR,0.62;95%CI,0.22-1.75,p=0.37),大截肢(或,0.59;95%CI,0.18-1.92,p=0.38),轻微截肢(或,0.64;95%CI,0.15-2.66,p=0.54)和愈合时间(MD,-0.001;糖尿病足溃疡患者的95%CI,-0.76至0.75,p=0.99)。检查的数据显示,高压氧治疗具有明显更高的愈合性溃疡,不良事件,溃疡面积减少和死亡率降低,然而,糖尿病足溃疡患者的截肢时间和愈合时间与标准治疗相比无显著差异。然而,应注意其价值,因为大多数选定的检查样本量较低,而一些比较的选定研究数量较少.
The meta-analysis aimed to assess the effect of hyperbaric oxygen treatment on diabetic foot ulcers. Using dichotomous or contentious random or fixed effect models, the outcomes of this meta-analysis were examined and the odds ratio (OR) and the mean difference (MD) with 95% confidence intervals (CIs) were computed. 17 examinations from 1992 to 2022 were enrolled for the present meta-analysis, including 7219 people with diabetic foot ulcers. Hyperbaric oxygen treatment had a significantly higher healed ulcer (OR, 14.39; 95% CI, 4.02-51.52, p < 0.001), higher adverse event (OR, 2.14; 95% CI, 1.11-4.11, p = 0.02), lower mortality (OR, 0.22; 95% CI, 0.07-0.71, p = 0.01) and higher ulcer area reduction (MD, 23.39; 95% CI, 11.79-34.99, p < 0.001) compared to standard treatment in patients with diabetic foot ulcers. However, hyperbaric oxygen treatment and standard treatment had no significant difference in amputation (OR, 0.62; 95% CI, 0.22-1.75, p = 0.37), major amputation (OR, 0.59; 95% CI, 0.18-1.92, p = 0.38), minor amputation (OR, 0.64; 95% CI, 0.15-2.66, p = 0.54) and healing time (MD, -0.001; 95% CI, -0.76 to 0.75, p = 0.99) in patients with diabetic foot ulcers. The examined data revealed that hyperbaric oxygen treatment had a significantly higher healed ulcer, adverse event, and ulcer area reduction and lower mortality, however, there was no significant difference in amputation and healing time compared to standard treatment in patients with diabetic foot ulcers. Yet, attention should be paid to its values since most of the selected examinations had a low sample size and some of the comparisons had a low number of selected studies.