■已知女性型脱发(FPHL)具有特征性病理状况,包括降低整体头发密度。雌性激素会影响头发状况;然而,详细机制未知。此外,由于衰老性脱发通常与FPHL同时发生,因此对该主题的研究变得复杂。因此,我们研究了雌二醇的作用,一种女性荷尔蒙,通过消除衰老因素并客观评估雌性激素替代疗法(HRT)引起的头发变化来促进头发生长。
■进行这项研究是为了阐明雌性激素对头发发挥作用的机制。
■该研究包括11名接受HRT的女性患者,这些患者在开始HRT之前进行了评估,开始HRT后3个月,和开始HRT后6个月。稀疏的头发分数,头发密度,静止毛发率,静止期拔除强度,毛发生长速率,测量和评价毛发厚度。此外,进行血液学检查以评估参与者的一般身体状况。
■HRT在3个月时增加了静止头发率(P=.010,配对t检验),改善额叶发际线变薄评分(P=.008,Wilcoxon检验),并在6个月时增加拔除强度(P=0.013,配对t检验)。
■这项研究的局限性包括样本量相对较小,由于参与者负担,无法进行进一步的长期测试,缺乏对照组。
■结果表明,HRT改善了额叶发际线的外观。由于很少有研究分析女性荷尔蒙对人类头发的影响,这项研究的一个新发现是在排除年龄因素后,雌二醇对拔除强度的影响。我们相信这些发现将有助于了解FPHL和开发与女性激素相关的治疗方法。
UNASSIGNED: Female pattern hair loss (FPHL) is known to present with characteristic pathological conditions, including reduced overall hair density. Female hormones affect hair condition; however, the detailed mechanism is unknown. Furthermore, research on the topic is complicated by the fact that senescent alopecia often occurs concurrently with FPHL. Therefore, we investigated the effect of estradiol, a female hormone, on hair growth by eliminating aging factors and objectively evaluating hair changes caused by female hormone replacement therapy (HRT).
UNASSIGNED: This study was conducted to elucidate the mechanism through which female hormones exert their effects on hair.
UNASSIGNED: The study included 11 female patients undergoing HRT who were evaluated before initiating HRT, 3 months after initiating HRT, and 6 months after initiating HRT. The thinning hair score, hair density, telogen hair rate, telogen plucking strength, hair growth rate, and hair thickness were measured and evaluated. Furthermore, hematological tests were performed to assess the general physical condition of the participants.
UNASSIGNED: HRT increased the telogen hair rate (P = .010, paired t test) at 3 months, improved frontal hairline thinning score (P = .008, Wilcoxon test), and increased the plucking strength (P = .013, paired t test) at 6 months.
UNASSIGNED: The limitation of this study included the relatively small sample size, inability to conduct further long-term tests because of participant burden, and lack of a control group.
UNASSIGNED: The results suggested that HRT improved the appearance of the frontal hairline. As few studies have analyzed the effects of female hormones on human hair, a novel finding of this study was the effects of estradiol on the plucking strength after excluding age as a factor. We believe that these findings will contribute to understanding FPHL and developing female hormone-related treatments.