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Background: The aim of the present randomized, crossover study was to determine the physiological and cognitive function responses while wearing a facemask during a maximal running aerobic fitness test. Methods: Fourteen healthy, nonsmoking physical education students (age = 17.5 years, height = 1.72 m, body mass = 70.4 kg) volunteered to participate in this study. They carried out a 20 m multistage fitness test (MSFT) while wearing or not a cloth facemask on two separate occasions performed in random order. The \"Rating of Perceived Exertion\" (RPE) and the d2 test for visual attention were administered and assessed before and immediately after the MSFT for both conditions (with or without a facemask). Results: When wearing the facemask, the participants exhibited lower maximal aerobic speed (p = 0.039), VO2max (p = 0.039), distance covered during the MSFT (p = 0.057), and concentration performance (p < 0.001), when compared with the control situation (without facemask). Moreover, they made more errors compared with the control condition (p = 0.021). The use of a cloth facemask during maximal endurance running tests (such as the MSFT) reduced VO2max, and measures of cognitive performance as assessed by the test of focused visual attention (the d2 test). This data suggests avoiding using a cloth facemask during maximal aerobic fitness tests, and before any tasks that require a high level of visual attention.

Introduction: The genetic disorder causing Down syndrome (DS) affects the cardiorespiratory and hemodynamic parameters. When exercising, sufficient blood flow is necessary for active muscles. Cardiac output (Q) must be proportional to the peripheral requirements. In case the stroke volume (SV) is lower, the heart rate (HR) will increase further in order to maintain an adequate blood flow in the active territories (HR compensatory response). People with DS have a lower HR response to maximal exercise. Nevertheless, the response of the hemodynamic and cardiorespiratory parameters during the submaximal phases of maximal exercise was not well studied. Objective: to evaluate cardiorespiratory and hemodynamic parameters 1) during submaximal and 2) maximal metabolic treadmill test in individuals with and without DS. Methods: fifteen adults with DS (age = 27.33 ± 4.98 years old; n = 12 males/3 females) and 15 adults without disabilities, matched by age and sex, participated in this cross-sectional study. Peak and submaximal cardiorespiratory and hemodynamic parameters were measured during a treadmill test. Linear mixed-effects models were used to analyse interactions between the variables. Post-hoc analyses were employed to assess within and between-group differences. Results: The DS group showed lower peak values for ventilation (VE), respiratory exchange ratio (RER), tidal volume (VT), ventilatory equivalent for O2 (VEqO2), end-tidal partial pressure for O2 (PETO2), O2 uptake (VO2) and CO2 production (all p < 0 .050), Q, SV, systolic and diastolic blood pressure (SBP, DBP), and HR (all p < 0 .050). There were group-by-time interactions (all p < 0 .050) for all ventilatory submaximal values. Significant group and time differences were observed for VE; RER; respiratory rate (RR); VEqO2; PETO2; VO2, and VT (all p < 0 .050). There were also group-by-time interactions (all p < 0 .050) and group and time differences for SBP, mean arterial blood pressure (MAP) and HR (all p < 0.010). Conclusion: During submaximal exercise, we verified a compensatory response of HR, and greater VE and VO2 in the individuals with DS. In addition, we were able to observe that the DS group had a reduced SBP and MAP response to submaximal exercise. On the other hand, we found that adults with DS have lower peak hemodynamic and cardiorespiratory values, and a lower cardiac reserve. Further research is warranted to investigate the effects of these results on the general health of adults with DS and the impact of long-term exercise programs on these parameters.

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BACKGROUND: Being physically active on a regular basis has a favourable impact on diabetes-related complications. With the exception of evidence advising individuals with an active diabetic foot ulceration (DFU) to avoid weight-bearing activity, no physical activity (PA) recommendations are currently provided for this population.
OBJECTIVE: The aim of this scoping review was to examine and map the existing research evidence of PA participation for individuals with an active DFU.
METHODS: A scoping review using the Arksey and O\'Malley framework was conducted in electronic databases and grey literature from inception to June 2020 to identify publications that investigated individuals with type 1 or type 2 diabetes and an active DFU at enrolment in relation to a PA intervention. Reported outcomes had to inform on effects of PA on any health or wound parameters.
RESULTS: Nineteen articles from 17 distinct studies met inclusion criteria. Fourteen of the included studies were published in the last 10 years. Types of exercises and materials used, duration of studies, offloading considerations and provision of wound care varied greatly between studies. Included studies are heterogenous in methodological designs and aims, and reporting was often lacking important components of wound care and PA interventions. A discussion based on descriptive statistics and narrative analysis is provided.
CONCLUSIONS: It is not possible from this scoping review to determine what would be the ideal components of a PA program for this specific population. Conclusions are limited by the quality and design of the included studies. No articles evaluated quality of life, mortality or cardiorespiratory capacity, nor were adverse effects routinely reported.

Exosomes are small bi-lipid membranous vesicles (30-150 nm) containing different biological material such as proteins, lipids and nucleic acid. These small vesicles, inducing a cell to cell signaling pathway, are able to mediate multidirectional crosstalk to maintain homeostasis or modulate disease processes. With their various contents, exosomes sort and transfer specific information from their origin to a recipient cell, from a tissue or organ in the close proximity or at distance, generating an intra-inter tissue or organ communication. In the last decade exosomes have been identified in multiple organs and fluids under different pathological conditions. In particular, while the content and the abundance of exosome is now a diagnostic marker for cardiovascular diseases, their role in context-specific physiological and pathophysiological conditions in the cardiovascular system remains largely unknown. We summarize here the current knowledge on the role of exosomes as mediators of cardiovascular diseases in several pathophysiological conditions such as atherosclerosis and diabetes. In addition, we describe evidence of intercellular connection among multiple cell type (cardiac, vasculature, immune cells) as well as the challenge of their in vivo analysis.

Purpose: Physical activity level is a prognostic variable for patients with injuries. Self-report questionnaires exist to obtain these measures; however, they are not accessible to all populations because of language barriers. Therefore, the purpose of this study was to translate and validate the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) for francophones. Method: We translated the HSS Pedi-FABS using the forward-reverse translation approach and validated it among bilingual adults and an expert panel before administering it to a paediatric population. A repeated-measures crossover design was used: forty-three middle school students, aged 13.1 (SD 0.75) years, were randomly administered either the English or the French questionnaire. Two days later, all participants completed the other version. The translated questionnaire was assessed for its convergent validity (Spearman\'s r correlation coefficients [rs ]), internal consistency (Cronbach\'s α), and reliability (standard error of measurement [SEM]). Results: All assessments had a significance level of p < 0.001 with an excellent Spearman\'s r correlation coefficient between the participants\' total scores on the translated questionnaires (rs  = 0.911). The overall scores for the questionnaire and the individual items of the questionnaire revealed excellent internal consistency (α = 0.868) and reliability (SEM = 0.334). Conclusions: The validated and reliable translated questionnaire can be used by researchers and clinicians to assess physical activity levels in French paediatric populations.
Objectif : le niveau d’activité physique est un pronostic variable pour les patients qui présentent des blessures. Il existe des questionnaires d’autoévaluation pour obtenir ces mesures, mais ils ne sont pas accessibles à toutes les populations à cause de la barrière de la langue. La présente étude visait à traduire et à valider le Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) pour les francophones. Méthodologie : les chercheurs ont traduit le HSS Pedi-FABS au moyen du processus de rétrotraduction et l’ont validé auprès d’adultes bilingues et d’un groupe d’experts avant de l’utiliser auprès d’une population pédiatrique. Ils ont utilisé une méthodologie transversale par mesures répétées : 43 élèves du début du secondaire de 13,1 ans (ÉT 0,75) ont répondu au hasard au questionnaire anglais ou français. Deux jours plus tard, tous les participants ont rempli l’autre version. Les questionnaires traduits ont été évalués pour leur validité convergente (coefficients de corrélation Rho de Spearman [rs ]), leur cohérence interne (coefficient alpha [α] de Cronbach) et leur fiabilité (erreur type de mesure). Résultats : toutes les évaluations présentaient un seuil de signification de p < 0,001 et un excellent coefficient de corrélation Rho de Spearman entre les scores totaux des participants dans les questionnaires traduits (rs  = 0,911). Les scores totaux du questionnaire et de chacun de ses éléments ont révélé une excellente cohérence interne (α = 0,868) et une excellente fiabilité (erreur type de mesure = 0,334). Conclusion : le questionnaire validé et traduit avec fiabilité peut être utilisé par les chercheurs et les cliniciens pour évaluer les niveaux d’activité physique de populations pédiatriques francophones.

Purpose: We systematically reviewed the effectiveness of interventions to increase physical activity in older adults (aged ≥ 60 y), admitted for inpatient rehabilitation, without increasing the amount of therapy. Method: Five electronic databases were systematically searched to identify English-language articles reporting controlled trials of interventions to increase the physical activity (through participation or behavioural change) of older adults receiving inpatient rehabilitation. Trials were excluded if an intervention increased the intensity of usual care, either during the week or on the weekend. Two reviewers independently completed trial selection, quality assessment, and data extraction. Data were synthesized descriptively, and effect sizes with 95% CIs were calculated. Results: Of the 316 articles identified, 3 were included. Two were activity-based, and 1 was a behavioural change intervention. Physical activity was significantly improved in the behavioural change intervention trial that occurred during therapy (d = 0.27; 95% CI: 0.02, 0.52) and non-therapy time (d = 0.43; 95% CI: 0.19, 0.68). Participants in all trials were sedentary for the vast majority of the day. Conclusions: Older adults in inpatient rehabilitation have a high level of inactivity. Evidence is lacking that interventions increase physical activity in older adults admitted to inpatient rehabilitation without increasing the amount of time in therapy. Evidence from one trial indicates that behaviour-based strategies are effective for increasing physical activity levels in the inpatient rehabilitation setting.
Objectif : analyse systématique de l’efficacité des interventions pour accroître l’activité physique chez les personnes âgées (de 60 ans et plus) hospitalisées en réadaptation, sans accroître la durée de la thérapie. Méthodologie : les chercheurs ont fait une fouille systématique dans cinq bases de données électroniques pour trouver des articles en anglais sur des études contrôlées d’interventions visant à accroître l’activité physique (par la participation ou le changement de comportement) de personnes âgées hospitalisées en réadaptation. Ils ont exclu les études dont l’intervention accroissait l’intensité des soins habituels pendant la semaine ou la fin de semaine. Deux analystes ont procédé à la sélection indépendante des études, à l’évaluation de la qualité et à l’extraction des données. Les chercheurs ont effectué la synthèse descriptive et calculé l’ampleur de l’effet à l’aide de l’intervalle de confiance à 95 %. Résultats : trois études ont été retenues sur les 316 articles extraits. Deux reposaient sur l’activité et une était une intervention pour changer le comportement. L’activité physique s’améliorait considérablement dans l’étude sur l’intervention visant à changer le comportement pendant la durée de la thérapie (d = 0,27; IC à 95 % : 0,02, 0,52) et sans thérapie (d = 0,43; IC à 95 % : 0,19, 0,68). Dans toutes les études, les participants étaient sédentaires pendant la plus grande partie de la journée. Conclusion : les personnes âgées hospitalisées en réadaptation présentent des taux élevés d’inactivité. Les données probantes sont insuffisantes pour déterminer si les interventions accroissent l’activité physique chez les personnes âgées hospitalisées en réadaptation sans accroître la durée de la thérapie. Selon les données probantes d’une étude, des stratégies axées sur le comportement sont efficaces pour accroître le taux d’activité physique lors d’une hospitalisation en réadaptation.