Optical Coherence Tomography (OCT) is a light-based imaging modality that is used widely in the diagnosis and management of eye disease, and it is starting to become used to evaluate for ear disease. However, manual image analysis to interpret the anatomical and pathological findings in the images it provides is complicated and time-consuming. To streamline data analysis and image processing, we applied a machine learning algorithm to identify and segment the key anatomical structure of interest for medical diagnostics, the tympanic membrane. Using 3D volumes of the human tympanic membrane, we used thresholding and contour finding to locate a series of objects. We then applied TensorFlow deep learning algorithms to identify the tympanic membrane within the objects using a convolutional neural network. Finally, we reconstructed the 3D volume to selectively display the tympanic membrane. The algorithm was able to correctly identify the tympanic membrane properly with an accuracy of ~98% while removing most of the artifacts within the images, caused by reflections and signal saturations. Thus, the algorithm significantly improved visualization of the tympanic membrane, which was our primary objective. Machine learning approaches, such as this one, will be critical to allowing OCT medical imaging to become a convenient and viable diagnostic tool within the field of otolaryngology.

UNASSIGNED: The rate at which the anticancer drug paclitaxel is cleared from the body markedly impacts its dosage and chemotherapy effectiveness. Importantly, paclitaxel clearance varies among individuals, primarily because of genetic polymorphisms. This metabolic variability arises from a nonlinear process that is influenced by multiple single nucleotide polymorphisms (SNPs). Conventional bioinformatics methods struggle to accurately analyze this complex process and, currently, there is no established efficient algorithm for investigating SNP interactions.
UNASSIGNED: We developed a novel machine-learning approach called GEP-CSIs data mining algorithm. This algorithm, an advanced version of GEP, uses linear algebra computations to handle discrete variables. The GEP-CSI algorithm calculates a fitness function score based on paclitaxel clearance data and genetic polymorphisms in patients with nonsmall cell lung cancer. The data were divided into a primary set and a validation set for the analysis.
UNASSIGNED: We identified and validated 1184 three-SNP combinations that had the highest fitness function values. Notably, SERPINA1, ATF3 and EGF were found to indirectly influence paclitaxel clearance by coordinating the activity of genes previously reported to be significant in paclitaxel clearance. Particularly intriguing was the discovery of a combination of three SNPs in genes FLT1, EGF and MUC16. These SNPs-related proteins were confirmed to interact with each other in the protein-protein interaction network, which formed the basis for further exploration of their functional roles and mechanisms.
UNASSIGNED: We successfully developed an effective deep-learning algorithm tailored for the nuanced mining of SNP interactions, leveraging data on paclitaxel clearance and individual genetic polymorphisms.

UNASSIGNED: The global aging population presents a significant challenge, with older adults experiencing declining physical and cognitive abilities and increased vulnerability to chronic diseases and adverse health outcomes. This study aims to develop an interpretable deep learning (DL) model to predict adverse events in geriatric patients within 72 hours of hospitalization.
UNASSIGNED: The study used retrospective data (2017-2020) from a major medical center in Taiwan. It included non-trauma geriatric patients who visited the emergency department and were admitted to the general ward. Data preprocessing involved collecting prognostic factors like vital signs, lab results, medical history, and clinical management. A deep feedforward neural network was developed, and performance was evaluated using accuracy, sensitivity, specificity, positive predictive value (PPV), and area under the receiver operating characteristic curve (AUC). Model interpretation utilized the Shapley Additive Explanation (SHAP) technique.
UNASSIGNED: The analysis included 127,268 patients, with 2.6% experiencing imminent intensive care unit transfer, respiratory failure, or death during hospitalization. The DL model achieved AUCs of 0.86 and 0.84 in the validation and test sets, respectively, outperforming the Sequential Organ Failure Assessment (SOFA) score. Sensitivity and specificity values ranged from 0.79 to 0.81. The SHAP technique provided insights into feature importance and interactions.
UNASSIGNED: The developed DL model demonstrated high accuracy in predicting serious adverse events in geriatric patients within 72 hours of hospitalization. It outperformed the SOFA score and provided valuable insights into the model\'s decision-making process.

BACKGROUND: The accuracy of movement determination software in current activity trackers is insufficient for scientific applications, which are also not open-source.
OBJECTIVE: To address this issue, we developed an accurate, trainable, and open-source smartphone-based activity-tracking toolbox that consists of an Android app (HumanActivityRecorder) and 2 different deep learning algorithms that can be adapted to new behaviors.
METHODS: We employed a semisupervised deep learning approach to identify the different classes of activity based on accelerometry and gyroscope data, using both our own data and open competition data.
RESULTS: Our approach is robust against variation in sampling rate and sensor dimensional input and achieved an accuracy of around 87% in classifying 6 different behaviors on both our own recorded data and the MotionSense data. However, if the dimension-adaptive neural architecture model is tested on our own data, the accuracy drops to 26%, which demonstrates the superiority of our algorithm, which performs at 63% on the MotionSense data used to train the dimension-adaptive neural architecture model.
CONCLUSIONS: HumanActivityRecorder is a versatile, retrainable, open-source, and accurate toolbox that is continually tested on new data. This enables researchers to adapt to the behavior being measured and achieve repeatability in scientific studies.

Despite ongoing safety efforts, construction sites experience a concerningly high accident rate. Notwithstanding that policies and research to reduce the risk of accidents in the construction industry have been active for a long time, the accident rate in the construction industry is considerably higher than in other industries. This trend may likely be further exacerbated by the rapid growth of large-scale construction projects driven by urban population expansion. Consequently, accurately predicting recovery periods of accidents at construction sites in advance and proactively investing in measures to mitigate them is critical for efficiently managing construction projects. Therefore, the purpose of this study is to propose a framework for developing accident prediction models based on the Deep Neural Network (DNN) algorithm according to the scale of the construction site. This study suggests DNN models and applies the DNN for each construction site scale to predict accident recovery periods. The model performance and accuracy were evaluated using mean absolute error (MAE) and root-mean-square error (RMSE) and compared with the widely used multiple regression analysis model. As a result of model comparison, the DNN models showed a lower prediction error rate than the regression analysis models for both small-to-medium and large construction sites. The findings and framework of this study can be applied as the opening stage of accident risk assessment using deep learning techniques, and the introduction of deep learning technology to safety management according to the scale of the construction site is provided as a guideline.

In this work, we present a method for optical frequency multiplication utilizing a hybrid deep learning approach that integrates the Residual Network (ResNet) with the Random Forest Regression (RFR) algorithm. Three different frequency multiplication modulation schemes are adopted to illustrate the method, which can obtain suitable parameters for these schemes. Based on the parameters predicted by the algorithm, the 8-tupling, 12-tupling, and 16-tupling mm-wave signals are generated by numerical simulation. The simulation results show that for 8-tupling frequency multiplication, an OSSR (optical sideband suppression ratio) is 30.73 dB and an RFSSR (radio frequency spurious suppression ratio) of 80 GHz is 42.29 dB. For 12-tupling frequency multiplication, the OSSR is 30.09 dB, and the RFSSR of the 120 GHz mm wave is 36.21 dB. For generating 16-tupling frequency mm-wave, an OSSR of 29.86 dB and an RFSSR of 34.52 dB are obtained. In addition, the impact of amplitude fluctuation and bias voltage drift on the quality of mm-wave signals is also studied.

Clear cell renal carcinoma (ccRCC), the most common subtype of renal cell carcinoma, has the high heterogeneity of a highly complex tumor microenvironment. Existing clinical intervention strategies, such as target therapy and immunotherapy, have failed to achieve good therapeutic effects. In this article, single-cell transcriptome sequencing (scRNA-seq) data from six patients downloaded from the GEO database were adopted to describe the tumor microenvironment (TME) of ccRCC, including its T cells, tumor-associated macrophages (TAMs), endothelial cells (ECs), and cancer-associated fibroblasts (CAFs). Based on the differential typing of the TME, we identified tumor cell-specific regulatory programs that are mediated by three key transcription factors (TFs), whilst the TF EPAS1/HIF-2α was identified via drug virtual screening through our analysis of ccRCC\'s protein structure. Then, a combined deep graph neural network and machine learning algorithm were used to select anti-ccRCC compounds from bioactive compound libraries, including the FDA-approved drug library, natural product library, and human endogenous metabolite compound library. Finally, five compounds were obtained, including two FDA-approved drugs (flufenamic acid and fludarabine), one endogenous metabolite, one immunology/inflammation-related compound, and one inhibitor of DNA methyltransferase (N4-methylcytidine, a cytosine nucleoside analogue that, like zebularine, has the mechanism of inhibiting DNA methyltransferase). Based on the tumor microenvironment characteristics of ccRCC, five ccRCC-specific compounds were identified, which would give direction of the clinical treatment for ccRCC patients.

We have demonstrated the utility of SYNAPSE VINCENT® (version 6.6; Fujifilm Medical Co., Ltd., Tokyo, Japan), a 3D image analysis system, in semi-automated simulations of the peripancreatic vessels, pancreatic ducts, pancreatic parenchyma, and peripancreatic organs using an artificial intelligence (AI) engine developed with deep learning algorithms. Furthermore, we investigated the usefulness of this AI engine for patients with pancreatic cancer. Here, we present a case of laparoscopic distal pancreatectomy with an extended surgical procedure performed using surgical simulation and navigation via an AI engine. An 80-year-old woman presented with abdominal pain. Enhanced abdominal computed tomography (CT) revealed main pancreatic duct dilatation with a maximum diameter of 40 mm. Furthermore, there was a 17 mm cystic lesion between the pancreatic head and the pancreatic body and a 14 mm mural nodule in the pancreatic tail. Thus, the lesion was preoperatively diagnosed as an intraductal papillary carcinoma (IPMC) of the pancreatic tail and classified as T1N0M0 stage IA according to the 8th edition of the Union for International Cancer Control guidelines. The present patient had laparoscopic distal pancreatectomy and regional lymphadenectomy. In particular, since it was necessary to include the cystic lesion in the pancreatic neck, pancreatic resection was performed at the right edge of the portal vein, which is closer to the head of the pancreas than usual. We routinely employed three-dimensional computer graphics (3DCG) surgical simulation and navigation, which allowed us to recognize the surgical anatomy, including the location of pancreatic resection. In addition to displaying the detailed 3DCG of the surgical anatomy, this technology allowed surgical staff to share the situation, and it has been reported that this approach improves the safety of surgery. Furthermore, the remnant pancreatic volume (47.6%), pancreatic resection surface area (161 mm2), and thickness of the pancreatic parenchyma (12 mm) at the resection location were investigated using 3DCG imaging. Intraoperative frozen biopsy confirmed that the resection margin was negative. Histologically, an intraductal papillary mucinous neoplasm with low-grade dysplasia was observed in the pancreatic tail. No malignant findings, including those related to the resection margin, were observed in the specimen. At the 12-month postoperative follow-up examination, the patient\'s condition was unremarkable. We conclude that the SYNAPSE VINCENT® AI engine is a useful surgical support for the extraction of the surrounding vessels, surrounding organs, and pancreatic parenchyma including the location of the pancreatic resection even in the case of extended surgical procedures.

Deception is an inevitable occurrence in daily life. Various methods have been used to understand the mechanisms underlying brain deception. Moreover, numerous efforts have been undertaken to detect deception and truth-telling. Functional near-infrared spectroscopy (fNIRS) has great potential for neurological applications compared with other state-of-the-art methods. Therefore, an fNIRS-based spontaneous lie detection model was used in the present study. We interviewed 10 healthy subjects to identify deception using the fNIRS system. A card game frequently referred to as a bluff or cheat was introduced. This game was selected because its rules are ideal for testing our hypotheses. The optical probe of the fNIRS was placed on the subject\'s forehead, and we acquired optical density signals, which were then converted into oxy-hemoglobin and deoxy-hemoglobin signals using the Modified Beer-Lambert law. The oxy-hemoglobin signal was preprocessed to eliminate noise. In this study, we proposed three artificial neural networks inspired by deep learning models, including AlexNet, ResNet, and GoogleNet, to classify deception and truth-telling. The proposed models achieved accuracies of 88.5%, 88.0%, and 90.0%, respectively. These proposed models were compared with other classification models, including k-nearest neighbor, linear support vector machines (SVM), quadratic SVM, cubic SVM, simple decision trees, and complex decision trees. These comparisons showed that the proposed models performed better than the other state-of-the-art methods.

UNASSIGNED: Previous deep learning (DL) algorithms for brain metastasis (BM) detection and segmentation have not been commonly used in clinics because they produce false-positive findings, require multiple sequences, and do not reflect physiological properties such as necrosis. The aim of this study was to develop a more clinically favorable DL algorithm (RLK-Unet) using a single sequence reflecting necrosis and apply it to automated treatment response assessment.
UNASSIGNED: A total of 128 patients with 1339 BMs, who underwent BM magnetic resonance imaging using the contrast-enhanced 3D T1 weighted (T1WI) turbo spin-echo black blood sequence, were included in the development of the DL algorithm. Fifty-eight patients with 629 BMs were assessed for treatment response. The detection sensitivity, precision, Dice similarity coefficient (DSC), and agreement of treatment response assessments between neuroradiologists and RLK-Unet were assessed.
UNASSIGNED: RLK-Unet demonstrated a sensitivity of 86.9% and a precision of 79.6% for BMs and had a DSC of 0.663. Segmentation performance was better in the subgroup with larger BMs (DSC, 0.843). The agreement in the response assessment for BMs between the radiologists and RLK-Unet was excellent (intraclass correlation, 0.84).
UNASSIGNED: RLK-Unet yielded accurate detection and segmentation of BM and could assist clinicians in treatment response assessment.