目的:记录使用无细胞猪角膜基质(APCS)兽用(BioCorneaVet™)恢复犬角膜完整性的角膜移植的有效性和结果。
方法:对接受APCS移植修复深层角膜缺损的角膜移植术患者的医疗记录进行回顾,次生孢子,并在2019年至2021年之间进行了穿孔。只有具有完整眩目反射的动物,本研究考虑在手术前同意PLR和至少4周的随访,40只狗(每只1只眼睛)符合纳入标准。
结果:短脑品种最常见,20只右眼和20只左眼受到25个穿孔的影响,8个次生孢子,和9个深层基质缺损(1只眼同时出现穿孔和后腺囊肿)。大多数患者患有并发眼病或曾在另一只眼睛上进行过手术。使用两种不同厚度的异种移植物(300或450µm),直径范围从3到10毫米。术后并发症包括轻度至重度角膜血管化,部分开裂,熔化,和青光眼。随访时间28~797天,平均233天。37/40例(92.5%)保持眼部完整,36例(90%)保留了视力。
结论:使用APCS(BioCorneaVet™)是治疗深部基质缺损的有效手术方法,后代囊肿,和狗的穿孔,提供良好的构造支持,保持解剖完整性和视野。在所有情况下,美容外观被认为是良好的,并且随着时间的推移持续改善。
OBJECTIVE: To document the effectiveness and outcome of corneal grafting using acellular porcine corneal stroma (APCS) for veterinary use (BioCorneaVet™ ) to restore corneal integrity in dogs.
METHODS: A review of medical records of patients that underwent keratoplasty with APCS graft to repair deep corneal defects, descemetoceles, and perforations between 2019 and 2021 was carried out. Only animals with intact dazzle reflex, consensual PLR before the surgery and a minimum follow-up of four weeks were considered for the study, with forty dogs (1 eye each) meeting the inclusion criteria.
RESULTS: Brachycephalic breeds were the most frequently represented, and 20 right eyes and 20 left eyes were affected with 25 perforations, 8 descemetoceles, and 9 deep stromal defects (1 eye had both perforation and descemetocele). Most of the patients had concurrent ocular diseases or had undergone previous surgery on the other eye. Two different thickness of xenograft was used (300 or 450 µm), and the diameter ranged from 3 to 10 mm. Postoperative complications included mild to severe corneal vascularization, partial dehiscence, melting, and glaucoma. Follow-up time ranged from 28 to 797 days (mean: 233 days). Ocular integrity was maintained in 37/40 cases (92.5%), and vision was preserved in 36 cases (90%).
CONCLUSIONS: The use of APCS (BioCorneaVet™ ) is an effective surgical treatment for deep stromal defects, descemetocele, and perforations in dogs, providing a good tectonic support and preserving anatomical integrity and vision. The cosmetic appearance was considered good in all the cases and continued to improve with time.