clinical case report

临床病例报告
  • 文章类型: Case Reports
    在低收入和中等收入国家(LMICs),由于诊断成像的可用性有限,肝脓肿的诊断和管理很困难。有限的数据描述了在资源有限的国家/地区,在诊断和经皮穿刺肝脓肿中使用即时超声(POCUS)。我们描述了一名21岁的女性,她被诊断患有肝脓肿。肝脓肿的诊断是通过POCUS,患者成功接受了经验性抗菌药物和反复POCUS辅助经皮穿刺抽吸术治疗.在资源有限的设置中,充分的人员培训和POCUS的可用性可能有助于肝脓肿的早期诊断和治疗-从而有助于降低其相关的发病率和死亡率-同时也有助于资源节约.
    Diagnosis and management of liver abscesses in low- and middle-income countries (LMICs) is difficult due to limited diagnostic imaging availability. Limited data is available describing the use of point-of-care ultrasound (POCUS) in the diagnosis and percutaneous aspiration of liver abscesses in resource-limited countries. We describe a 21-year-old female who was diagnosed with a liver abscess. The diagnosis of liver abscess was made via POCUS, and the patient was successfully managed with empiric antimicrobials and repeated POCUS-assisted percutaneous needle aspiration. In resource-limited settings, adequate training of personnel and availability of POCUS may help in early diagnosis and treatment of liver abscess - thus helping to reduce its related morbidity and mortality - while also aiding in resource conservation.
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  • 文章类型: Case Reports
    我们描述了一名21岁男性的未成熟纵隔畸胎瘤向高级别血管肉瘤的罕见和显着转变。纵隔畸胎瘤,尤其是不成熟的,非常罕见,代表一小部分生殖细胞肿瘤(GCT)。我们的案例描述了患者的临床旅程,他最初表现为急性胸痛,随后在影像学检查和肿瘤标志物升高后被诊断为未成熟畸胎瘤。尽管以顺铂为基础的化疗最初有阳性反应,监测成像显示肝脏肿块,活检证实为血管肉瘤。这种转化强调了未成熟畸胎瘤的侵袭性和肉瘤分化的倾向,特别是在纵隔。该病例有助于纵隔非精原细胞瘤生殖细胞肿瘤(MNGCT)的管理和监测,文献有限的GCT子集。我们认为,该病例是文献中第一个描述纵隔未成熟畸胎瘤向高级别血管肉瘤转变的病例。
    We describe a rare and remarkable transformation of an immature mediastinal teratoma into high-grade angiosarcoma in a 21-year-old male. Mediastinal teratomas, particularly immature ones, are exceedingly rare, representing a small fraction of germ cell tumors (GCTs). Our case describes the clinical journey of the patient, who initially presented with acute chest pain and was subsequently diagnosed with an immature teratoma following imaging studies and elevated tumor markers. Despite an initial positive response to cisplatin-based chemotherapy, surveillance imaging revealed liver masses, which a biopsy confirmed as angiosarcoma. This transformation underscores the aggressive nature of immature teratomas and the propensity for sarcomatous differentiation, particularly in the mediastinum. The case contributes valuable insight into the management and surveillance of mediastinal non-seminoma germ cell tumors (MNGCT), a subset of GCTs with limited literature. We believe this case is the first in the literature to describe a transformation from an immature teratoma in the mediastinum to a high-grade angiosarcoma.
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  • 文章类型: Case Reports
    中风模拟物难以彼此区分。症状性癫痫也可发生,但是有必要进行磁共振成像(MRI)扫描以将其与中风区分开。尽管据报道,由于长时间的呼吸暂停,部分发作性癫痫发作会发生呼吸性酸中毒,很少怀疑呼吸性酸中毒是癫痫的征兆。我们报告了一例呼吸性酸中毒有助于诊断中风模仿的症状性癫痫。患者是一名52岁的女性,她被带到急诊室,主要抱怨说话困难。当她去医院时,观察到感觉失语,并进行了计算机断层扫描(CT)扫描。她在CT扫描后呕吐了,动脉血气分析显示pH值为7.26,PaCO2水平为71mmHg,提示呼吸性酸中毒.服用地西泮后,癫痫发作减轻,感觉失语症改善。稍后,对患者病史的调查显示有症状的癫痫和抗癫痫药物的停药.如果在中风模仿患者中发现无法解释的呼吸性酸中毒,进一步调查患者的病史和体格检查可能有助于诊断症状性癫痫。
    Stroke mimics are difficult to differentiate from each other. Symptomatic epilepsy can also occur, but it is necessary to perform a magnetic resonance imaging (MRI) scan to distinguish it from a stroke. Although respiratory acidosis has been reported to occur with partial-onset seizures due to prolonged apnea, respiratory acidosis is rarely suspected to be a sign of epilepsy. We report a case in which respiratory acidosis helped to diagnose symptomatic epilepsy with stroke mimics. The patient was a 52-year-old female who was brought to the emergency room with the chief complaint of difficulty in talking. When she visited the hospital, sensory aphasia was observed, and a computed tomography (CT) scan was performed. She vomited after the CT scan, and an arterial blood gas analysis showed a pH of 7.26 with a PaCO2 level of 71 mmHg, indicating respiratory acidosis. After the administration of diazepam, the seizures abated and her sensory aphasia improved. Later, an investigation of the patient\'s history revealed symptomatic epilepsy and discontinuation of antiepileptic drugs. If unexplained respiratory acidosis is noted in a patient with stroke mimics, a further investigation of the patient\'s history and physical examination may help to diagnose symptomatic epilepsy.
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  • 文章类型: Case Reports
    关于COVID-19对胰腺影响的报道越来越多。胰腺炎,由于高甘油三酯血症,也有报道。假设机制包括噬血细胞淋巴组织细胞增多症(HLH)综合征和获得性脂蛋白脂酶(LPL)抑制剂。我们介绍了一名51岁的女性患者,她出现了恶心,呕吐,上腹部腹痛放射到背部。在检查中,她有全身腹部压痛,没有保护或反弹压痛。我们的检查显示脂肪酶升高了1150单位/升,甘油三酯(TG)为11340mg/dL,腹部计算机断层扫描(CT)扫描显示轻度胰腺炎。在第2天,她开发了一种新的需氧量,并检测出COVID-19呈阳性。她因胰腺炎接受了液体和阿片类药物治疗,血浆置换,注射胰岛素来治疗她的高甘油三酯血症.她因急性COVID-19感染接受了雷米西韦治疗。甘油三酯降低到<500毫克/分升治疗,她因口服降脂药出院回家。通过讨论这个案子,我们的目标是阐明COVID-19与高甘油三酯血症之间的关系,这可能进一步导致危及生命的并发症,如急性胰腺炎。需要进一步的研究来确定确切的机制,预防措施,以及COVID-19对甘油三酯和胰腺的长期影响。
    There are increasing reports of the effects of COVID-19 on the pancreas. Pancreatitis, as a result of hypertriglyceridemia, has also been reported. Hypothesized mechanisms include hemophagocytic lymphohistiocytosis (HLH) syndrome and acquired lipoprotein lipase (LPL) inhibitors. We present a 51-year-old female patient who presented with nausea, vomiting, and epigastric abdominal pain radiating to the back. On examination, she had generalized abdominal tenderness without guarding or rebound tenderness. Our workup revealed elevated lipase of 1150 units/L, triglycerides (TG) of 11340 mg/dL, and mild pancreatitis on an abdominal computed tomography (CT) scan. On day 2, she developed a new oxygen requirement and tested positive for COVID-19. She was treated with fluids and opiates for pancreatitis, plasmapheresis, and an insulin infusion to treat her hypertriglyceridemia. She was treated with remdesivir for an acute COVID-19 infection. Triglycerides decreased to <500 mg/dL with treatment, and she was discharged home on oral lipid-lowering agents. By discussing this case, we aim to shed light on the association between COVID-19 and hypertriglyceridemia, which can further lead to life-threatening complications such as acute pancreatitis. Further studies are needed to identify the exact mechanisms, preventive measures, and long-term effects of COVID-19 on triglycerides and the pancreas.
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  • 文章类型: Case Reports
    脂肪瘤是自然界中普遍存在的良性软组织肿瘤。现有文献表明,良性肿瘤是无害的,除非它们的大小增加,导致重要结构的压缩。此病例报告讨论了一名52岁男子的病例,他无痛地出现在诊所,在他的嘴的右侧增长肿块。患者的症状包括吞咽困难和说话困难,这导致医生建议手术切除肿块。在肿块切除手术期间没有问题,切口愈合而不损害舌神经或舌下神经或沃顿氏管,正如在后续访问中观察到的那样。患者病史,症状,术前检查,治疗策略,手术技术都包括在这个案例研究中,专注于口腔脂肪瘤的极不寻常发展,特别是在嘴巴的地板上。
    Lipomas are benign soft tissue tumors that are ubiquitous in nature. Available literature suggests that benign tumors are harmless unless they increase in size, resulting in compression of vital structures. This case report discusses the case of a 52-year-old man who presented to the clinic with a painless, growing lump on the right side of his mouth. The patient\'s symptoms included difficulty swallowing and speaking, which led the doctors to recommend surgical excision of the mass. There were no issues during the mass removal surgery, and the incision healed without compromising the lingual or hypoglossal nerves or Wharton\'s duct, as observed during follow-up visits. Patient history, symptoms, preoperative examination, treatment strategy, and surgical technique are all included in this case study, which focuses on the extremely unusual development of lipomas in the oral cavity, particularly on the floor of the mouth.
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  • 文章类型: Case Reports
    脑动静脉畸形(cAVM)是脑血管的发育性病理损害,其中多个动脉将血液直接分流到静脉引流网络中。它们是病因不清楚的病变,如果不及时治疗,可能承受偏头痛等并发症的重大风险,癫痫发作,神经功能缺损,颅内出血.诊断基于几种成像方法,血管造影是主要方法。治疗方式包括显微外科手术,放射外科,意图闭塞的栓塞,和各种多学科方法。我们旨在介绍一名有症状的cAVM成年女性患者的病例,该患者接受了病变的部分血管内栓塞治疗,并评估其恢复情况和治疗方式的总体可靠性。一名22岁的女性患者出现在神经外科诊所,临床表现为光敏性癫痫发作,偏头痛,和持续一年的睡眠障碍史。指定的MRI和血管造影显示,位于左脑半球顶内沟内的大脑中动脉前顶支的肾小球cAVM(Spetzler-Martin2级)。畸形的静脉引流导致周围脑实质中的营养损失(偷窃现象),导致癫痫发作。患者成功接受了Onyx经动脉血管内栓塞,在术后血管造影中被证明是局部的,并拒绝进一步的栓塞手术。术后无并发症。患者在12个月的随访中没有报告癫痫发作或睡眠障碍。伴随着零星的微弱头痛。cAVM在未诊断时仍然是具有显著发病率和死亡率的病理学。当畸形具有适当的血管结构时,仅通过血管内栓塞就可以可靠地管理导致盗血现象和癫痫发作的症状性cAVM。location,尺寸,和低Spetzler-Martin得分.然而,在进一步的多阶段栓塞手术被拒绝和/或病变完全闭塞不可行的情况下,需要进一步调查部分栓塞的使用情况.该病例报告强调,部分血管内栓塞可以成功地用作由cAVM静脉引流的盗血现象引起的症状的治疗方式,如癫痫和偏头痛,在极少数情况下,当患者拒绝多阶段栓塞并且病变的闭塞仍然是次要的。
    Cerebral arteriovenous malformations (cAVMs) are developmental pathologic lesions of the blood vessels of the brain in which multiple arteries shunt blood directly into the venous drainage network. They are lesions with an unclear etiology and, if left untreated, can bear significant risks of complications such as migraines, seizures, neurological deficits, and intracranial hemorrhages. The diagnosis is based on several imaging methods, with angiography being the primary method. Treatment modalities include microsurgery, radiosurgery, embolization with the intent of obliteration, and various multidisciplinary approaches. We aim to introduce the case of an adult female patient with symptomatic cAVM who underwent partial endovascular embolization of the lesion and evaluate her recovery and the overall reliability of her treatment modality. A 22-year-old female patient has presented to the Neurosurgery Clinic with clinical manifestations with photosensitive seizures, migraines, and a history of sleep disturbances persisting for a period of one year. An appointed MRI and angiography revealed the presence of a glomerular cAVM of the anterior parietal branch of the middle cerebral artery located within the intraparietal sulcus of the left cerebral hemisphere (Spetzler-Martin grade 2). The venous drainage of the malformation led to a loss of nutrients in the surrounding brain parenchyma (a steal phenomenon), causing the seizures. The patient successfully underwent transarterial endovascular embolization with Onyx, which proved to be partial on a postoperative angiography, and refused further embolization procedures. There were no postoperative complications to be mentioned. The patient reported no seizures or sleep disturbances at the 12-month follow-up, with sporadic weak headaches remaining. cAVMs remain a pathology with significant morbidity and mortality when undiagnosed. Symptomatic cAVMs leading to a steal phenomenon and seizures can be reliably managed via endovascular embolization alone when the malformation has an appropriate angioarchitecture, location, size, and a low Spetzler-Martin score. However, further inquiry is required into the use of partial embolization in cases where further multiple-stage embolization procedures are declined and/or complete occlusion of the lesion is unfeasible. This case report emphasizes that partial endovascular embolization can be successfully utilized as a treatment modality for the symptoms caused by a steal phenomenon of the venous drainage of a cAVM, such as seizure disorders and migraines, in the rare instance when multiple-stage embolization is declined by the patient and occlusion of the lesion remains subtotal.
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  • 文章类型: Case Reports
    神经性囊肿,也被称为Tarlov囊肿,是罕见的良性脑脊液填充囊肿,通常位于后神经根和背根神经节的交界处,通常无症状。它们最常见于骶骨区域,在颈椎中并不常见。尽管它们很少,有症状的病例可能由于邻近神经结构的压迫而出现神经症状。症状性宫颈神经周围囊肿极为罕见,关于管理策略的共识有限。我们介绍了一名56岁的女性,她有四周的神经根症状史,涉及右C7和C8神经根,包括颈部和手臂疼痛,感觉异常,和轻微的三头肌无力.磁共振成像显示在C6-C7和C7-T1水平有两个神经囊肿。选择了保守的方法,口服皮质类固醇14天的疗程,使用柔软的领子,和活动限制。经过这种保守治疗,症状显著减轻,神经系统完全恢复.此病例强调了保守方法在某些轻度症状的宫颈神经周囊肿病例中的疗效,并有助于更好地了解这种情况的管理策略。
    Perineural cysts, also known as Tarlov cysts, are rare benign cerebrospinal fluid-filled cysts usually located at the junction of the posterior nerve root and the dorsal root ganglion and are usually asymptomatic. They are most commonly found in the sacral region and are uncommon in the cervical spine. Despite their rarity, symptomatic cases may present with neurological symptoms due to the compression of adjacent neurological structures. Symptomatic cervical perineural cysts are extremely rare, and there is limited consensus on management strategies. We present the case of a 56-year-old woman who presented with a four-week history of radicular symptoms involving the right C7 and C8 nerve roots, including neck and arm pain, paresthesias, and mild triceps weakness. Magnetic resonance imaging revealed two perineural cysts at the C6-C7 and C7-T1 levels. A conservative approach was chosen with a 14-day course of oral corticosteroids, use of a soft collar, and activity restrictions. Following this conservative treatment, a significant reduction in symptoms and complete neurological recovery were achieved. This case highlights the efficacy of conservative approaches in selected cases of mildly symptomatic cervical perineural cysts and contributes to a better understanding of management strategies for this condition.
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  • 文章类型: Case Reports
    慢性肠道血吸虫病(CIS)是指肠道中血吸虫寄生虫感染的长期影响。这种情况通常在反复或长时间暴露于含有血吸虫卵的受污染淡水后发展。目前的研究报告了一个成年男性的案例,主诉腹部和肛门异常疼痛一个月,有复杂肛周瘘病史。内镜检查显示不同程度的充血,集中在乙状结肠和直肠。病变位于直肠和乙状结肠。黄色颗粒状增生,无论是浓缩还是分散,单个或多个息肉,随着粘膜充血的观察,水肿,微弱的血管条纹,侵蚀,浅表溃疡,并注意到散见性出血。此外,结肠的分段区域有不同程度的炎症。显微组织病理学分析显示是手术疤痕组织的罪魁祸首。肉芽肿在粘膜下深度有血吸虫寄生虫。此外,结肠粘膜组织出现糜烂,伴有淋巴浆细胞性和微脓肿浸润。在粘膜下水平的肉芽肿中观察到血吸虫。内镜和组织病理学检查是区分CIS和克罗恩病的有用工具。这些工具可以区分CIS和克罗恩病。早期发现和治疗对于预防疾病进展和最大限度地减少长期并发症至关重要。
    Chronic intestinal schistosomiasis (CIS) refers to the long-term effects of infection with Schistosoma parasites in the intestines. This condition typically develops after repeated or prolonged exposure to contaminated freshwater containing Schistosoma eggs. The current study reports a case of an adult male, who complained of abnormal abdominal and anal pain for a month and had a medical history of complex perianal fistulae. The endoscopic investigation revealed different degrees of hyperemia, concentrated in the sigmoid colon and rectum. Lesions were localized in the rectum and sigmoid colon. Yellow granular hyperplasia, whether concentrated or dispersed, single or multiple polyps, along with observations of mucosal congestion, edema, faint vascular striations, erosions, superficial ulcers, and scattered petechial hemorrhages were noted. Also, the segmented areas of the colon had different degrees of inflammation. The microscopic histopathological analysis showed a culprit of surgical scar tissue. The granulomas harbored Schistosome parasites at the submucosal depth. Also, an erosion in the colonic mucosal tissues accompanied by lymphoplasmacytic and micro-abscess infiltrates was seen. A Schistosoma bilharzial ova was observed in the granuloma at the submucosal level. Endoscopic and histopathological investigations are useful tools to differentiate between CIS and Crohn\'s disease. These tools can distinguish CIS from Crohn\'s disease. Early detection and treatment are essential to prevent the progression of the disease and minimize long-term complications.
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  • 文章类型: Case Reports
    我们报告了一例31岁的gravida2para1女性,在妊娠29周时有两周的视力模糊和持续性头痛病史。呈现时的视敏度在右眼为6/100,在左眼为6/24。双眼眼底镜检查显示,在没有背景视网膜变化的情况下,浆液性视网膜脱离。在紧急进入产妇评估单位时,血压为189/126mmHg,尿液试纸显示4蛋白尿。由于心脏造影监测中反复出现的不良胎儿心率变异性,进行了紧急剖腹产。交货后16小时,视觉症状有所改善,临床检查显示血压正常。三个月后进行的光学相干断层扫描扫描双侧干燥,视网膜色素上皮少量结块。浆液性视网膜脱离涉及神经感觉视网膜层与下面的视网膜色素上皮的分离。它在先兆子痫中很少见,但在严重疾病的患者中可以看到。浆液性视网膜脱离的表现包括急性视力丧失,视力下降,漂浮物,和闪烁的灯光出现在视野中。尽管在最初的介绍中令人震惊,决议通常在产后几天内看到。浆液性视网膜脱离发展的致病机制已被广泛讨论,并认为包括脉络膜循环的变化。总的来说,虽然经常自我解决,对先兆子痫妇女进行彻底的产前护理和警惕监测对于防止此类并发症的发生至关重要。
    We report a case of a 31-year-old gravida 2 para 1 female presenting to the optician with a two-week history of blurred vision and persistent headaches at 29 weeks gestation. Visual acuity on presentation was 6/100 in the right eye and 6/24 in the left eye. Fundoscopy of both eyes revealed serous retinal detachment in the absence of background retinal changes. On urgent admission to the maternity assessment unit, blood pressure was 189/126 mmHg and urine dipstick revealed 4+ proteinuria. Due to recurrent poor foetal heart rate variability on cardiotocography monitoring, an emergency caesarean was conducted. Sixteen hours following delivery, visual symptoms had improved, and clinical examination revealed normal blood pressure. An optical coherence tomography scan performed three months later was dry bilaterally with minor retinal pigment epithelium clumping. Serous retinal detachment involves the separation of the neurosensory retinal layer from the underlying retinal pigment epithelium. It is rare in pre-eclampsia but can be seen in patients with severe disease. The presentation of serous retinal detachment includes acute visual loss, reduced visual acuity, floaters, and flashing lights appearing in the vision. Although alarming on initial presentation, resolution is commonly seen within a couple of days postpartum. The pathogenic mechanism for serous retinal detachment development is widely discussed and thought to include changes to the choroidal circulation. Overall, although often self-resolving, a move to thorough antenatal care and vigilant monitoring in pre-eclamptic women is vital to prevent complications like this from occurring.
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  • 文章类型: Case Reports
    在对标准治疗方法无反应或厌恶的患者中,针刺治疗面肌痉挛(HFS)的疗效和最佳频率仍未确定。这里,我们对1例对注射肉毒杆菌毒素(BoNT)的结果不满意的HFS患者进行针灸对症治疗.一个60多岁的男人,自2015年以来,他的左面部肌肉经常痉挛,在没有接受微血管减压或药物治疗的情况下接受了多次BoNT注射;然而,治疗效果不理想。2020年,他访问了我们的针灸诊所。他整个脸都不由自主地抽搐着,另一个巴宾斯基标志被观察到了。在数字评定量表(NRS)上,痉挛的严重程度为5。沿面神经和GB14,GB1,小肠子午线(SI)18,ST4,ST5和ST9对胆囊子午线(GB)2,胃子午线(ST)7和三重能量子午线(TE)17进行针刺患侧(左)。在第四届会议上,ST7和TE17的1Hz电针将NRS评分降低到1。由于他的痉挛得到了很好的控制,我们最初继续每两周进行一次针灸治疗.然而,在第十届会议之前,症状恶化导致恢复每周治疗,在第21届会议之前,NRS得分一直下降。我们的发现表明,对于对常规治疗无反应或厌恶的HFS患者,每周针灸可能是一种可行的治疗方式。未来的前瞻性临床试验需要验证针灸治疗HFSs的疗效。
    The efficacy and optimal frequency of acupuncture for hemifacial spasms (HFSs) in patients unresponsive or averse to standard treatment methods remains unestablished. Here, we administered acupuncture to a patient with HFSs who was dissatisfied with the outcomes of botulinum toxin (BoNT) injections as symptomatic treatment. A man in his 60s, experiencing frequent spasms in his left facial muscles since 2015, had received several BoNT injections without receiving microvascular decompression or medication; however, the treatment results were not satisfactory. In 2020, he visited our clinic for acupuncture. His entire face twitched involuntarily, and the other Babinski sign was observed. The spasm severity was 5 on the numerical rating scale (NRS). Acupuncture was performed on the gallbladder meridian (GB) 2, stomach meridian (ST) 7, and triple energizer meridian(TE) 17 along the facial nerve and GB14, GB1, small intestine meridian (SI) 18, ST4, ST5, and ST9 on the affected (left) side. In the fourth session, 1 Hz electroacupuncture at ST7 and TE17 reduced the NRS score to 1. As his spasms were well managed, we initially continued with biweekly acupuncture sessions. However, by the 10th session, a worsening of symptoms led to a revert to weekly treatment, which maintained a decreased NRS score until the 21st session. Our findings suggest that weekly acupuncture may be a viable treatment modality for patients with HFSs unresponsive or averse to conventional treatments. Future prospective clinical trials are required to verify the efficacy of acupuncture for HFSs.
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