背景:新证据表明蜂胶可能降低血清炎症介质水平;因此,在这项研究中,我们旨在证明蜂胶对血清白细胞介素-6(IL-6)水平的潜在影响,C反应蛋白(CRP),和肿瘤坏死因子-α(TNF-α)进行系统评价和荟萃分析。
方法:包括PubMed、ClinicalTrials.gov,Scopus,科克伦图书馆,和ISIWebofScience一直搜索到2023年10月。在目前的荟萃分析中,我们通过DerSimonian和Laird方法,使用提取的两个研究组的标准均值差异(SMD)和标准差(SD)检测了总体效应大小.通过Cochran的Q检验和I平方统计量来探索统计异质性。
结果:总计,17和16项研究被纳入系统评价和荟萃分析,分别。总体估计表明蜂胶显着降低IL-6的血清水平(SMD=-3.47,95%置信区间(95CI):-5.1,-1.84;p<0.001),CRP(SMD=-1.73,95CI:-2.82,-0.65;p=0.002),和TNF-α(SMD=-1.42,95CI=-2.15,-0.68;p<0.001)。这些结果还揭示了地理区域和蜂胶剂量是获得有益效果的关键点。
结论:根据我们的结果,补充蜂胶可以降低血清IL-6,CRP,和TNF-α;因此,它可能被认为是治疗某些慢性疾病的补充疗法。
BACKGROUND: New evidence suggested that propolis might reduce serum levels of inflammatory mediators; therefore, in this study we aimed to prove the potential effect of propolis on serum levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-α) through conducting a systematic review and meta-analysis.
METHODS: Databases including PubMed, ClinicalTrials.gov, Scopus, Cochrane Library, and ISI Web of Science were searched until October 2023. In the present meta-analysis, we detected the overall effect sizes using extracted standard mean differences (SMD) and the standard deviations (SDs) from both study groups through DerSimonian and Laird method. Exploring the statistical heterogeneity was done through Cochran\'s Q test and I-squared statistic.
RESULTS: In total, seventeen and sixteen studies were included in the systematic review and meta-analysis, respectively. The overall estimate indicated that the propolis significantly reduced serum levels of IL-6 (SMD = -3.47, 95% confidence interval (95%CI): -5.1, -1.84; p < 0.001), CRP (SMD= -1.73, 95%CI: -2.82, -0.65; p = 0.002), and TNF-α (SMD= -1.42, 95%CI= -2.15, -0.68; p < 0.001). These results also revealed geographical region and propolis dose were the critical points to get the beneficial effects.
CONCLUSIONS: According to our result, propolis supplementation can decrease serum levels of IL-6, CRP, and TNF-α; therefore, it might be considered as complementary therapy for the treatment of certain chronic diseases.