autograft

自体移植物
  • 文章类型: Journal Article
    最近,腓骨长肌腱(PLT)在前交叉韧带(ACL)重建中越来越受欢迎,并已获得令人满意的结果。然而,有关于供体部位发病率的担忧。本研究旨在比较使用绳肌腱(HT)和PLT自体移植物重建ACL的功能结果,并评估供体部位的发病率。
    将接受ACL重建的患者分为两组(HT和PLT)。术中测量移植物直径。术前使用IKDC和Tegner-Lysholm评分评估膝关节功能结局,术后3个月,6个月,和1年。通过大腿围测量来评估供体部位的发病率。感觉障碍的主观评价,和脚踝得分与AOFAS和FADI得分。
    在1年的随访中,PLT组的IKDC(p=0.925)和Tegner-Lysholm(p=0.600)评分与HT组相当.PLT组的平均移植物直径(7.93±0.52mm)大于HT组(7.43±0.50mm)(p<0.001)。大腿萎缩的发生率(HT-16.7%,PLT-10%)和感觉障碍(HT-73.3%,HT组PLT-10%)更大。PLT组无明显踝关节供体部位发病率(AOFAS-98.67±3.45,FADI-99.23±1.69)。
    用PLT重建ACL在1年时具有与HT相当的功能结果。然而,PLT显示较大的移植物直径,供体部位发病率较低,增强肌肉恢复而不显著影响踝关节功能。PLT可以安全地用作从膝关节外收获的可接受的替代移植物选择,用于ACL重建。
    UNASSIGNED: Recently the peroneus longus tendon (PLT) gained popularity in anterior cruciate ligament (ACL) reconstruction and has been utilized with satisfactory outcomes. However, there are concerns regarding donor site morbidity. This study aims to compare the functional outcome of ACL reconstruction using hamstring (HT) and PLT autografts and evaluate the donor site morbidity.
    UNASSIGNED: Patients who underwent ACL reconstruction were allocated to two groups (HT and PLT). Graft diameter was measured intraoperatively. Knee functional outcome was evaluated with IKDC and Tegner-Lysholm scores preoperatively, and postoperatively after 3 months, 6 months, and 1 year. Donor site morbidities were assessed with thigh circumference measurements, subjective evaluation of sensory disturbances, and ankle scoring with AOFAS and FADI scores.
    UNASSIGNED: At 1-year follow-up, the PLT group showed comparable IKDC (p = 0.925) and Tegner-Lysholm (p = 0.600) scores with those of the HT group. The mean graft diameter in the PLT group (7.93 ± 0.52 mm) was larger compared with the HT group (7.43 ± 0.50 mm) (p < 0.001). The incidence of thigh atrophy (HT-16.7%, PLT-10%) and sensory disturbances (HT-73.3%, PLT-10%) was greater in the HT group. There was no significant ankle donor site morbidity in the PLT group (AOFAS-98.67 ± 3.45, FADI-99.23 ± 1.69).
    UNASSIGNED: ACL reconstruction with PLT had comparable functional outcome with that of HT at 1 year. However, PLT demonstrated larger graft diameter, less donor site morbidity, and enhanced muscle recovery without significantly affecting the ankle function. PLT can be safely used as an acceptable alternative graft choice harvested from outside the knee for ACL reconstruction.
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  • 文章类型: Journal Article
    通过放松来评估抗氧化活性和氧化损伤,受伤,在胸骨寄主上播种不同来源的saibo,包括五种牡蛎治疗:(1)放松(REL),但既不受伤也不播种;(2)放松和受伤(WOU),但未播种;(3)放松,受伤,并用同种异体移植物(ALL)播种;(4)放松,受伤,并用自体移植物(AUT)播种;(5)不放松,没有受伤,并且未播种作为对照(CTR)。超氧化物歧化酶(SOD),过氧化氢酶(CAT),谷胱甘肽过氧化物酶(GPx),和硫代巴比妥酸(TBARS)活性在接种后3至24小时之间进行定量。与CTR牡蛎相比,没有遭受氧化应激,在所有处理中,性腺和消化腺中的SOD活性均显着降低,而AUT牡蛎中的地幔组织则降低;这表明准备牡蛎进行珍珠培养的整个过程(放松,受伤,和播种)在宿主中产生氧化应激。CAT不是测量牡蛎对受伤播种过程的短期反应的敏感酶,而是更长时间或慢性的压力。类似于SOD,接种牡蛎中GPx和TBARS活性最低,证明了它们对氧化应激和损伤的敏感性,特别是在WOU治疗中。这项研究的证据表明,SOD是一种更敏感的酶,可用于测量寄主牡蛎对赛博受伤和播种的短期反应。很明显,在珍珠培养过程的所有阶段,宿主都会受到压力,主要是在性腺受伤期间,无论赛博的起源如何。
    To evaluate the antioxidant activity and oxidative damage by relaxing, wounding, and seeding of a saibo of different origin on Pteria sterna hosts, five oyster treatments were included: (1) relaxed (REL) but neither wounded nor seeded; (2) relaxed and wounded (WOU) but not seeded; (3) relaxed, wounded, and seeded with an allograft (ALL); (4) relaxed, wounded, and seeded with an autograft (AUT); and (5) unrelaxed, unwounded, and unseeded as control (CTR). Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and thiobarbituric acid (TBARS) activity were quantified between 3 and 24 h post-seeding. Compared to the CTR oysters, which did not suffer oxidative stress, SOD activity significantly decreased in the gonad and digestive gland in all treatments and decreased in mantle tissue in AUT oysters; this indicates that the entire process of preparing oysters for pearl culture (relaxing, wounding, and seeding) generates oxidative stress in the host. CAT was not a sensitive enzyme for measuring the short-term response of oysters to the wounding-seeding processes but rather a more prolonged or chronic stress. Similar to SOD, the lowest GPx and TBARS activity in seeded oysters evidenced their susceptibility to oxidative stress and damage, particularly in the WOU treatment. Evidence from this study indicates that SOD is a more sensitive enzyme for measuring the short-term response of the host oyster to the wounding and seeding of a saibo. It is also clear that the host undergoes stress at all stages of the pearl culture process, mostly during gonad wounding and regardless of the origin of saibo.
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  • 文章类型: Case Reports
    在牙周护理中,患者的结果对于指导外科技术的发展至关重要,牙龈衰退管理是一个关键问题。骨膜外翻技术(PET)是一种现代策略,它利用骨膜的内在再生能力来实现根覆盖。一个详细的案例研究展示了PET在处理MillerI类牙龈萎缩以及辅助富血小板纤维蛋白(PRF)手术中的有效性。这种方法需要将骨膜瓣故意抬高和外翻以包围衰退区域。通过缝合精心固定。在六个月的观察期中,这种方法表现出成功的根覆盖,角化组织的增加,增强了患者的舒适度,据报道,无明显并发症。这些结果为将PET纳入标准牙周治疗方案提供了支持,强调其重塑牙龈衰退治疗景观的能力。
    In periodontal care, where patient results are crucial in guiding the development of surgical techniques, gingival recession management is a critical issue. The periosteum eversion technique (PET) emerges as a modern strategy that leverages the intrinsic regenerative capabilities of the periosteum to attain root coverage. A detailed case study showcases the effectiveness of PET in managing a Miller Class I gingival recession alongside an adjunctive platelet-rich fibrin (PRF) procedure. This approach entailed the deliberate elevation and eversion of the periosteal flap to encompass the recession area, securing it meticulously through suturing. Across a six-month observation period, this method exhibited successful root coverage, augmentation of keratinized tissue, and enhanced patient comfort, as reported, with no significant complications observed. These outcomes provide support for the incorporation of PET into standard periodontal protocols, underscoring its capacity to reshape the treatment landscape for gingival recession.
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  • 文章类型: Journal Article
    在后外侧角(PLC)重建中存在几种手术技术和移植物类型的方法。文献缺乏有关PLC损伤的自体移植与同种异体移植重建后结果的知识。
    全面回顾目前关于PLC重建的文献,并比较自体移植和同种异体移植组织的结果。
    系统评价;证据水平,4.
    搜索PubMed和Scopus在线数据库时使用术语“PLC,膝关节后外侧,“后外侧角”,\"和\"重建\"在不同的组合。患者特征,移植物类型,移植失败,外科技术,功能结果评分,回顾了应力X线片上的内翻松弛度,并比较了自体移植物和同种异体移植物的PLC重建。
    包括22项研究,包括33个队列:16个自体移植物(n=280个膝盖)和17个同种异体移植物(336个膝盖)。有69个分离的PLC重建(58个同种异体移植物和11个自体移植物)和493个多韧带重建(269个自体移植物和224个同种异体移植物)。患者平均年龄没有差异(30.5岁vs33.5岁,分别为;P=.11)或平均随访时间(39.5vs37.7个月,分别;P=0.68)在自体移植组和同种异体移植组之间。没有证据表明移植物类型之间的移植物失败存在差异(自体移植物与同种异体移植物的合并平均值:0.44对0.41失败;P=.95)。自体移植物与同种异体移植物的术后Lysholm平均评分有显著差异(分别为89.6vs85.5;P=.04)。两组在术前或术后国际膝关节文献委员会(IKDC)评分或术后内翻松弛度方面没有差异。
    我们的综述和荟萃分析表明,仅基于移植物类型的PLC重建后,移植物失败率或客观结果没有显着差异。术后Lysholm评分与自体移植组有显著差异,IKDC主观评分无显著差异。
    UNASSIGNED: Several approaches to surgical techniques and graft types exist in posterolateral corner (PLC) reconstruction. The literature lacks knowledge regarding outcomes after autograft versus allograft reconstruction for PLC injuries.
    UNASSIGNED: To comprehensively review the current literature on PLC reconstruction and compare outcomes between autograft and allograft tissues.
    UNASSIGNED: Systematic review; Level of evidence, 4.
    UNASSIGNED: The PubMed and Scopus online databases were searched with the terms \"PLC,\"\"posterolateral knee,\"\"posterolateral corner,\" and \"reconstruction\" in varying combinations. Patient characteristics, graft type, graft failure, surgical techniques, functional outcome scores, and varus laxity on stress radiographs were reviewed and compared between PLC reconstruction with autografts versus allografts.
    UNASSIGNED: Included were 22 studies comprising 33 cohorts: 16 autografts (n = 280 knees) and 17 allografts (336 knees). There were 69 isolated PLC reconstructions (58 allografts and 11 autografts) and 493 multiligament reconstructions (269 autografts and 224 allografts). There was no difference in the mean patient age (30.5 vs 33.5 years, respectively; P = .11) or mean follow-up (39.5 vs 37.7 months, respectively; P = .68) between the autograft and allograft groups. There was no evidence to suggest a difference in graft failures between graft types (pooled mean autograft vs allograft: 0.44 vs 0.41 failures; P = .95). There was a significant difference in the mean postoperative Lysholm scores for autografts versus allografts (89.6 vs 85.5, respectively; P = .04). There was no difference between the cohorts in preoperative or postoperative International Knee Documentation Committee (IKDC) scores or postoperative varus laxity.
    UNASSIGNED: Our review and meta-analysis indicated no significant differences in graft failure rates or objective outcomes after PLC reconstruction based on graft type alone. There was a significant difference in postoperative Lysholm scores in favor of the autograft group and no significant difference in IKDC subjective scores.
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  • 文章类型: Journal Article
    与重返运动相比,前十字韧带(ACL)重建(ACLR)后重返工作(RTW)的时机是一个研究较少的里程碑。
    系统评价ACLR后RTW的发生率和术后时机。
    系统评价;证据水平,4.
    这项研究是根据2020PRISMA(系统审查和荟萃分析的首选报告项目)声明进行的。在PubMed中进行了文献检索,Embase,科克伦,以及用于报告ACLR后RTW的临床研究的Ovid数据库,2022年8月确定了806项研究。使用非随机研究方法学指数(MINORS)分级系统进行质量评估。从研究中提取以下数据:研究特征,队列人口统计,ACLR技术,伴随半月板和/或软骨手术,术前患者报告的结果,RTW的比率,以及ACLR后RTW所需的天数。
    共有13项研究符合纳入标准,总计1791名患者(86.4%为男性)。在评估研究的方法学质量中观察到广泛的差异(MINORS评分范围,8-17).76.8%的人使用了绳肌腱(HT)自体移植(n=1377;平均年龄,30.5岁),同种异体移植物占17.1%(n=308;平均年龄,33.1岁),韧带高级加固系统占2.5%(n=46;平均年龄,33.2岁),骨-髌腱-自体骨移植占2%(n=36;平均年龄,28.5岁),股四头肌腱自体移植占1.3%(n=24;平均年龄,24.1岁)。在纳入的患者中,99.1%(n=1781)报告术后RTW成功。RTW的平均时间为84.2天(范围,31.4-107.1天),适用于HT和69.5天(范围,49-56.6天)用于同种异体移植。
    虽然没有关于ACL损伤前后工作强度的数据,我们的研究结果表明,患者最常发生RTW在手术后90天内.同种异体移植物ACLR患者可能比接受HT自体移植物ACLR患者更早发生RTW。
    UNASSIGNED: The timing of return to work (RTW) after anterior cruciate ligament (ACL) reconstruction (ACLR) is a less studied milestone compared with return to sports.
    UNASSIGNED: To systematically review the rate and postoperative timing of RTW after ACLR.
    UNASSIGNED: Systematic review; Level of evidence, 4.
    UNASSIGNED: This study was conducted in accordance with the 2020 PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. A literature search was performed in PubMed, Embase, Cochrane, and Ovid databases for clinical studies reporting RTW after ACLR, and 806 studies were identified in August 2022. A quality assessment was performed using the Methodological Index of Nonrandomized Studies (MINORS) grading system. The following data were extracted from studies: study characteristics, cohort demographics, ACLR technique, concomitant meniscal and/or cartilage procedures, preoperative patient-reported outcomes, rates of RTW, and days required for RTW after ACLR.
    UNASSIGNED: A total of 13 studies met inclusion criteria, totaling 1791 patients (86.4% male). Wide variability was observed in the methodological quality of the assessed studies (MINORS score range, 8-17). Hamstring tendon (HT) autograft was used in 76.8% (n = 1377; mean age, 30.5 years old), allograft in 17.1% (n = 308; mean age, 33.1 years old), the ligament advanced reinforcement system in 2.5% (n = 46; mean age, 33.2 years old), bone-patellar tendon-bone autograft in 2% (n = 36; mean age, 28.5 years old), and quadriceps tendon autograft in 1.3% (n = 24; mean age, 24.1 years old). Among the included patients, 99.1% (n = 1781) reported successful RTW after surgery. The mean time to RTW was 84.2 days (range, 31.4-107.1 days) for HT and 69.5 days (range, 49-56.6 days) for allograft.
    UNASSIGNED: While data regarding work intensity before and after ACL injury were absent, our study results suggested that patients most often RTW within 90 days of surgery. Patients with allograft ACLR may RTW earlier than patients undergoing ACLR with HT autograft.
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  • 文章类型: Journal Article
    内侧髌股韧带重建是髌骨不稳定患者的标准治疗选择。这项研究的主要目的是确定是否使用双折叠分离解剖内侧髌股韧带重建,四股足底肌腱自体移植可恢复青少年患者的髌骨稳定性。通过近端入路收获植前肌腱移植物,并用于四名青少年患者。准备了双肢结构的四股自体移植物,并用缝合锚和干涉螺钉固定在髌骨和股骨上,分别。平均Kujala评分从44±24SD(范围,术前19至69)分至94±10SD(范围,术后78至100)分(P<0.001)。所有患者均报告了出色的主观结果,并恢复了受伤前的体育活动水平。在孤立的解剖内侧髌股韧带重建中使用四股肌腱自体移植物可以恢复青少年的髌骨稳定性。
    Medial patellofemoral ligament reconstruction is a standard treatment option for patients with patellar instability. The main purpose of this study was to determine whether isolated anatomic medial patellofemoral ligament reconstruction using double folded, four-strand plantaris tendon autograft restores patellar stability in adolescent patients. Plantaris tendon autografts were harvested through proximal approach and used in four adolescent patients. A four-strand autograft was prepared in a double-limbed configuration and fixed on the patella and the femur with suture anchors and interference screws, respectively. The mean Kujala score improved significantly from 44 ± 24 SD (range, 19 to 69) points preoperatively to 94 ± 10 SD (range, 78 to 100) points postoperatively (P< 0.001). All patients reported excellent subjective outcomes and returned to their pre-injury level of sporting activities. The use of a four-strand plantaris tendon autograft in isolated anatomic medial patellofemoral ligament reconstruction can restore patellar stability in adolescents.
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  • 文章类型: Editorial
    暂无摘要。
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  • 文章类型: Journal Article
    使用液氮进行保肢手术的骨肉瘤治疗可应用于截肢后生活质量下降的犬患者。特别是,前肢截肢可能比后肢截肢更影响步态。在这项研究中,使用液氮进行的保肢手术适用于威尔士柯基近端肩胛骨的原发性骨肉瘤,金毛猎犬的肱骨近端,和大比利牛斯山脉的桡骨远端,根据Tsuchiya等人的协议。在所有情况下,术后影像学检查显示治疗骨和基质骨之间的骨愈合。所有患者术后均恢复步态。这些结果表明,使用液氮处理的自体骨进行保肢手术是骨肉瘤患者的有效选择。
    Osteosarcoma treatment with limb-sparing surgery using liquid nitrogen can be applied to canine patients experiencing diminished quality of life after leg amputation. In particular, forelimb amputation may affect gait more than hindlimb amputation. In this study, limb-sparing surgery using liquid nitrogen was applied to primary osteosarcomas arising in the proximal scapula of a Welsh Corgi, the proximal humerus of a Golden Retriever, and the distal radius of a Great Pyrenees, according to the protocol of Tsuchiya et al. In all cases, postoperative radiographic examination revealed bone union between the treated and matrix bones. All patients recovered their gait postoperatively. These results suggest that limb-sparing surgery using liquid nitrogen-treated autologous bone is an effective option for patients with osteosarcoma.
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    文章类型: Journal Article
    Autografting with split-thickness skin grafts (STSG) remains an essential procedure in burn and reconstructive surgery. The process of harvesting STSG, however, leaves behind a donor site, an exposed area of partial-thickness dermis left to heal by secondary intention. There has yet to be a consensus amongst surgeons regarding optimal management of the donor site. The ideal donor site dressing is one that allows for expeditious healing while minimizing pain and infection. Despite numerous studies demonstrating the superiority of moist wound healing, many surgeons continue to treat STSG donor sites dry, with petroleum-based gauze. In this study, two burn centers performed a retrospective review of burn patients whose STSG donor sites were treated with either Xeroform® or Mepilex® Ag dressings. Infections were documented and in a subgroup analysis of patients, postoperative pain scores were noted and total opiate usage during hospitalization was calculated. Analysis revealed an overall infection rate of 1.2% in the Mepilex® Ag group and 11.4% in the Xeroform® group (p<0.0001). Patients with Xeroform® donor site dressings had increased odds of donor site infection (OR=10.8, p=0.002). In subgroup analysis, there were no significant differences in maximum pain scores between Mepilex® Ag and Xeroform® groups, nor were there differences in opiate usage. STSG donor sites dressed with silver foam dressings have a lower rate of donor site infection relative to those dressed with petroleum-based gauze. Moist donor site dressings such as foam dressings (including Mepilex® Ag) should be the standard of care in STSG donor site wound care.
    La greffes de peau mince (GPM) demeure une procédure essentielle dans la chirurgie de brûlure et de reconstruction. La zone donneuse de greffe (ZDG) représente une perte de substance cutanée superficielle, cicatrisant spontanément. Il n’y a pas de consensus concernant la prise en charge optimale de la ZDG. Le pansement idéal de la ZDG doit promouvoir la cicatrisation et réduire la douleur ainsi que le risque infectieux. Malgré les nombreuses publications montrant l’intérêt d’un environnement humide pour la cicatrisation, de nombreux chirurgiens réalisent des pansements secs vaselinés. Cette étude rétrospective effectuée dans 2 CTB compare les pansements de ZDG réalisés au Xéroform® ou au Mepilex Ag®. Les infections ont été documentées et, dans un sous-groupe, les scores de douleur et la consommation d’opiacés au long de l’hospitalisation ont été notés. Les taux d’infection sont de 1,2% dans le groupe Mepilex Ag® et 11,4% avec Xéroform® (p<0,0001). Le risque d’infection de la ZDG est augmenté (OR 10,8 ; p = 0,002) en cas d’utilisation de Xéroform®. Il n’y avait pas de différence de douleur et de consommation d’opiacés entre les 2 groupes. Les ZDG recouvertes d’un pansement hydrocellulaire imprégné d’argent s’infectent moins que celles traitées avec une gaze imprégnée de vaseline. L’utilisation sur les ZDG d’un pansement humide comme une mousse hydrocellulaire (par exemple Mepilex Ag®) devrait devenir la norme.
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  • 文章类型: Journal Article
    背景:在初次全膝关节置换术(TKA)期间处理未包含的胫骨近端内侧缺损可能具有挑战性,特别是对于深度≥10mm的缺陷。这项研究旨在评估自体结构骨移植的结果,以解决这些缺陷。
    方法:在这项前瞻性研究中,接受TKA的胫骨近端内侧缺损深度≥10mm的患者接受螺钉固定的自体结构性骨移植治疗,并随访至少36个月.对患者进行膝关节社会评分(KSS)和西安大略省和麦克马斯特大学骨关节炎指数(WOMAC)的临床随访。此外,进行放射学随访以评估植骨愈合和植入物稳定性。
    结果:该研究包括48名患者,平均年龄为69.2±4.5岁。平均体重指数(BMI)为31.4±3.7kg/m2。平均缺损深度为17±3.6mm。平均随访时间为52.2±12.3个月,中位KSS从术前30显著改善至89,P<0.001。中位WOMAC评分从术前的85显著降低至30.5,P<0.001。平均ROM从术前的73±12.4度显着增加到124±8.4度,P<0.001。平均移植物愈合时间为4.9±1个月。无明显并发症报告。
    结论:自体骨移植重建是解决原发性TKA中未包含的胫骨近端内侧缺损的安全有效方法。
    方法:四级。
    BACKGROUND: Management of uncontained medial proximal tibial defects during primary total knee arthroplasty (TKA) can be challenging, especially for defects ≥ 10 mm in depth. This study sought to assess the outcomes of autogenous structural bone grafts to address these defects.
    METHODS: In this prospective study, patients with uncontained medial proximal tibial defects ≥ 10 mm in depth undergoing TKA were managed by autogenous structural bone grafts fixed by screws and were followed up for at least 36 months. Patients were followed-up clinically with Knee Society Score (KSS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Additionally, radiological follow-up was done to assess bone graft union and implant stability.
    RESULTS: The study included 48 patients with a mean age of 69.2 ± 4.5 years. The mean body mass index (BMI) was 31.4 ± 3.7 kg/m2. The mean defect depth was 17 ± 3.6 mm. With a mean follow-up period of 52.2 ± 12.3 months, the median KSS improved significantly from 30 preoperatively to 89, P < 0.001. The median WOMAC score reduced significantly from 85 preoperatively to 30.5, P < 0.001. The mean ROM increased significantly from 73 ± 12.4 preoperatively to 124 ± 8.4 degrees, P < 0.001. The mean graft union time was 4.9 ± 1 months. No significant complications were reported.
    CONCLUSIONS: Autogenous bone graft reconstruction is a safe and effective method of addressing uncontained medial proximal tibial defects in primary TKA.
    METHODS: Level IV.
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