■工作记忆是指临时存储和操纵信息以支持计划的过程,决策,和行动。经常合并症的酒精滥用和睡眠不足都与工作记忆缺陷有关。然而,酒精滥用和睡眠不足如何影响工作记忆尚不清楚。在这项研究中,我们的目的是调查与酒精滥用相关的神经过程,睡眠不足和工作记忆。
■我们策划了HumanConnectomeProject(HCP)数据集,并调查了991名年轻人(521名女性)的工作记忆与酒精使用严重程度和睡眠不足的神经相关性。两者通过所有饮酒指标的主成分分析的第一主成分(PC1)和匹兹堡睡眠质量指数(PSQI)评分进行索引,分别。我们使用已发布的例程处理了成像数据,并使用校正的阈值评估了结果。我们使用路径模型来表征临床,行为,和神经测量,并探讨了调查结果中的性别差异。
■在全脑回归中,我们确定了背外侧前额叶皮层反应(DLPFCβ)对2-的β估计值。与PC1相关的0-back。在男性和女性中,DLPFC与PC1呈正相关(r=0.16,P<0.001)。路径分析显示,模型PC1→DLPFCβ→正确试验的反应时间差异(2-减去0-后;RT2-0)→关键成功指数差异(2-减去0-后;CSI2-0)具有最佳拟合。只有女人,除了DLPFC,上丘(SC)中的一个簇与PSQI评分呈显着负相关(r=-0.23,P<0.001),路径模型显示了PC1、PSQI得分、DLPFC和SCβ,和CSI2-0女性。
■酒精滥用可能涉及功能补偿中更高的DLPFC激活,然而,只有女性,睡眠不足通过抑制SC活动影响2回记忆。只有女性,路径模型表明饮酒严重程度和睡眠不足对双回记忆的影响是相互关联的。这些发现表明,饮酒和睡眠问题对工作记忆的影响存在潜在的性别差异,需要进一步研究。
UNASSIGNED: Working memory refers to a process of temporary storage and manipulation of information to support planning, decision-making, and action. Frequently comorbid alcohol misuse and sleep deficiency have both been associated with working memory deficits. However, how alcohol misuse and sleep deficiency interact to impact working memory remains unclear. In this study, we aim to investigate the neural processes inter-relating alcohol misuse, sleep deficiency and working memory.
UNASSIGNED: We curated the Human Connectome Project (HCP) dataset and investigated the neural correlation of working memory in link with alcohol use severity and sleep deficiency in 991 young adults (521 women). The two were indexed by the first principal component (PC1) of principal component analysis of all drinking metrics and Pittsburgh Sleep Quality Index (PSQI) score, respectively. We processed the imaging data with published routines and evaluated the results with a corrected threshold. We used path model to characterize the inter-relationship between the clinical, behavioral, and neural measures, and explored sex differences in the findings.
UNASSIGNED: In whole-brain regression, we identified β estimates of dorsolateral prefrontal cortex response (DLPFC β) to 2- vs. 0-back in correlation with PC1. The DLPFC showed higher activation in positive correlation with PC1 across men and women (r=0.16, P<0.001). Path analyses showed the model PC1 → DLPFC β → differences in reaction time (2- minus 0-back; RT2-0) of correct trials → differences in critical success index (2- minus 0-back; CSI2-0) with the best fit. In women alone, in addition to the DLPFC, a cluster in the superior colliculus (SC) showed a significant negative correlation with the PSQI score (r=-0.23, P<0.001), and the path model showed the inter-relationship of PC1, PSQI score, DLPFC and SC β\'s, and CSI2-0 in women.
UNASSIGNED: Alcohol misuse may involve higher DLPFC activation in functional compensation, whereas, in women only, sleep deficiency affects 2-back memory by depressing SC activity. In women only, path model suggests inter-related impact of drinking severity and sleep deficiency on 2-back memory. These findings suggest potential sex differences in the impact of drinking and sleep problems on working memory that need to be further investigated.