PDF(Pubmed)
Abstract：
Alcohol use disorder (AUD) is a significant contributor to morbidity and mortality in the United States. It contributes to over 140,000 annual deaths, to over 200 related diseases and health conditions globally, and accounts for 5.1% of the global disease burden. Despite its substantial impact, AUD remains undertreated, marked by a scarcity of approved medications. This paper explores the current treatment landscape and novel strategies for both alcohol withdrawal syndrome and AUD. Promising results, including the use of psychedelics alongside psychotherapy, noninvasive neural-circuit-based interventions, phosphodiesterase-4 inhibitors, and GLP-1 receptor agonists, have emerged from recent studies. While these advancements show potential, further research is crucial for a comprehensive understanding of their effectiveness. The clear shortage of approved medications and other treatment modalities underscores the pressing need for ongoing research.
摘要：
酒精使用障碍（AUD）是美国发病率和死亡率的重要因素。它导致每年超过14万人死亡，全球200多种相关疾病和健康状况，占全球疾病负担的5.1%。尽管影响很大,AUD仍未得到充分治疗,以批准的药物稀缺为标志。本文探讨了酒精戒断综合征和AUD的当前治疗前景和新策略。有希望的结果，包括在心理治疗的同时使用迷幻药，基于神经回路的非侵入性干预措施，磷酸二酯酶-4抑制剂，和GLP-1受体激动剂，从最近的研究中得出。虽然这些进步显示出潜力，进一步的研究对于全面了解其有效性至关重要。批准的药物和其他治疗方式的明显短缺强调了正在进行的研究的迫切需要。
