有忧郁,通常被称为Ashwagandha,已经流行了很多年了。大量研究表明,这种植物的提取物,由于其丰富的活性物质,可以诱导抗炎,神经保护,免疫调节,保肝,心脏保护,抗糖尿病,适应性,抗关节炎,抗压力,和抗菌作用。这篇综述研究了Ashwagandha提取物对血管内皮的影响,炎症,脂质代谢,和心血管结果。研究表明,Ashwagandha提取物通过降低微血管的平均密度来抑制血管内皮生长因子(VEGF)诱导的毛细血管发芽和形成,从而表现出抗血管生成作用。此外,大量研究的结果强调了Ashwagandha提取物的抗炎作用,因为这种植物的作用导致促炎细胞因子的表达减少。有趣的是,与anolides,目前在Ashwagandha根,已经显示出抑制前脂肪细胞分化为脂肪细胞的能力。研究结果还证明,由于其抗氧化特性和减少缺血/再灌注诱导的细胞凋亡,睡眠菌具有心脏保护作用。似乎这种植物可以成功地用作几种条件的潜在治疗方法,主要是炎症增加的。需要进行更多的研究来阐明睡梦草提取物中所含物质在人体中作用的确切机制。
Withania somnifera, commonly known as Ashwagandha, has been popular for many years. Numerous studies have shown that the extract of this plant, due to its wealth of active substances, can induce anti-inflammatory, neuroprotective, immunomodulatory, hepatoprotective, cardioprotective, anti-diabetic, adaptogenic, anti-arthritic, anti-stress, and antimicrobial effects. This review examines the impact of Ashwagandha extract on the vascular endothelium, inflammation, lipid metabolism, and cardiovascular outcomes. Studies have shown that Ashwagandha extracts exhibit an anti-angiogenic effect by inhibiting vascular endothelial growth factor (VEGF)-induced capillary sprouting and formation by lowering the mean density of microvessels. Furthermore, the results of numerous studies highlight the anti-inflammatory role of Ashwagandha extract, as the action of this plant causes a decrease in the expression of pro-inflammatory cytokines. Interestingly, withanolides, present in Ashwagandha root, have shown the ability to inhibit the differentiation of preadipocytes into adipocytes. Research results have also proved that W. somnifera demonstrates cardioprotective effects due to its antioxidant properties and reduces ischemia/reperfusion-induced apoptosis. It seems that this plant can be successfully used as a potential treatment for several conditions, mainly those with increased inflammation. More research is needed to elucidate the exact mechanisms by which the substances contained in W. somnifera extracts can act in the human body.