Spinal Stenosis

椎管狭窄
  • 文章类型: Journal Article
    背景:通过磁共振图像(MRI)分析未命名的层间韧带(ILL)的特征,内镜和病理检查。
    方法:回顾性研究分析2021年1月至2022年2月在我们医疗中心接受后路内窥镜手术治疗腰椎间盘突出症或腰椎管狭窄症患者的临床资料。高度,使用T2加权MRI分析韧带的宽度和横截面厚度.同时,还将形态学和病理学特征与黄韧带进行了比较,以强调上述韧带之间的差异。
    结果:本研究纳入了43例患者,包括27名男性和16名女性,平均年龄为46.6±12.1.腰椎间盘突出症20例,腰椎管狭窄症23例。宽度,长度,ILL的厚度,腰椎间盘组的LF厚度和手术时间为17.7±3.5mm,4.3±1.3mm,18.3±3.5mm,5.3±1.9mm,53.2±14.5min,分别。在腰椎管狭窄组中,相应参数为16.0±3.1mm,4.1±1.6mm,17.6±4.8mm,6.3±0.8mm,61.8±12.4min,分别。黄韧带厚度的组间差异有统计学意义(P=0.02)。手术时间的差异也得到了证实(P=0.04)。在两个韧带之间的锚点位置和外观方面,确定了内窥镜差异。在活检中也观察到纤维结构的密度和方向的显着差异。在内窥镜下,在疾病谱方面进行比较时,确定了ILL厚度等级的显着差异(P=0.09。)结论:层间韧带是一种尚未正式命名的结构,与黄韧带有显著的结构差异。对于后路内窥镜手术,其临床意义在于其能够作为软组织通道建立的终点。MRI中的黄韧带厚度和内窥镜下的ILL厚度根据疾病谱而变化。
    BACKGROUND: To analyze the characteristics of an unnamed interlaminar ligaments(ILL) through magnetic resonance image (MRI), endoscopy and pathological examination.
    METHODS: A retrospective study was conducted to analyze the clinical data of patients who underwent posterior endoscopic surgery for lumbar disc herniation or lumbar spinal stenosis from January 2021 to February 2022 at our medical center. The height, width and cross-sectional thickness of the ligament was analyzed using T2 weighted MRI. Meanwhile, the morphological and pathological characteristics were also compared with those of the ligamentum flavum to highlight the differences between above mentioned ligaments.
    RESULTS: Forty-three patients were included in this study, including 27 males and 16 females, with an average age of 46.6 ± 12.1y. There were 20 cases of lumbar disc herniation and 23 cases of lumbar spinal stenosis. The width, length, thickness of the ILL, the thickness of LF and surgical time in the lumbar disc group were 17.7 ± 3.5 mm, 4.3 ± 1.3 mm, 18.3 ± 3.5 mm, 5.3 ± 1.9 mm, 53.2 ± 14.5 min, respectively. In the lumbar spinal stenosis group, the corresponding parameters were 16.0 ± 3.1 mm, 4.1 ± 1.6 mm, 17.6 ± 4.8 mm, 6.3 ± 0.8 mm, 61.8 ± 12.4 min, respectively. The intergroup difference in thickness of the ligamentum flavum was statistically significant (P = 0.02). The difference in surgical time was also established(P = 0.04). Endoscopic differences were identified as to the location of the anchor points and appearances among the two ligaments. Significant differences in the density and direction of fibrous structures were also observed under biopsy. Under endoscopy, significant difference as to the grade of ILL thickness was established when compared regarding disease spectrum (P = 0.09.) CONCLUSION: The interlaminar ligament is a structure that has not yet been officially named, which has significant structural differences from those of the ligamentum flavum. For posterior endoscopic procedure, its clinical significance lies in its ability to serve as the endpoint of soft tissue channel establishment. The thickness of the ligamentum flavum in MRI and the thickness of ILL under endoscopy vary according to the disease spectrum.
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  • 文章类型: Journal Article
    背景:单侧椎板切开双侧减压术(ULBD)在腰椎管狭窄症(LSS)的治疗中取得了积极的效果。由于微创手术(MIS)的进展,单侧双门静脉ULBD(UB-ULBD)和经皮内窥镜ULBD(PE-ULBD)越来越受欢迎。这项研究的目的是评估和比较UB-ULBD和PE-ULBD的影像学和临床结果。
    方法:本研究回顾性纳入因LSS而接受ULBD手术的患者。根据手术方法将患者分为两组:UB-ULBD组和PE-ULBD组。一般人口统计数据,手术细节,临床疗效,对比两组患者的X线摄影及并发症发生情况。最短随访时间为12个月。
    结果:共纳入了在我们机构接受过ULBD的113例LSS患者,其中61例患者接受了UB-ULBD手术,52例接受了PE-ULBD手术。UB-ULBD组手术时间明显缩短(P<0.05)。UB-ULBD组的小面保存明显优于PE-ULBD组,UE-ULBD组同侧小关节切除角度明显较小(P<0.05)。ODI得分,两组术后VAS评分和改良的Macnab标准均有改善。UB-ULBD组有95.08%的优秀或良好的患者结果,而PE-ULBD组有92.30%的发生率。
    结论:当用于治疗LSS时,UB-ULBD和PE-ULBD均可提供良好的临床结果。UB-ULBD是有益的,因为它的操作时间短,较小角度的同侧小关节切除和更好的小关节保留,使其成为治疗LSS的可行和安全的选择,同时确保脊柱的稳定性。
    BACKGROUND: Unilateral laminotomy for bilateral decompression (ULBD) has yielded positive results in the treatment of lumbar spinal stenosis (LSS). Unilateral biportal ULBD (UB-ULBD) and percutaneous endoscopic ULBD (PE-ULBD) are gaining popularity because of the progress that has been made in minimally invasive surgery (MIS). The objective of this study was to evaluate and compare the radiographic and clinical results of UB-ULBD and PE-ULBD.
    METHODS: This study retrospectively enrolled patients who underwent ULBD surgery for LSS. The patients were categorized into two groups on the basis of the surgical method: the UB-ULBD group and the PE-ULBD group. Data on the general demographic data, surgical details, clinical efficacy, radiography and complications were compared between the two groups were compared. The minimum follow-up duration was 12 months.
    RESULTS: A total of 113 LSS patients who had undergone ULBD at our institution were included, of whom 61 patients underwent UB-ULBD surgery and 52 underwent PE-ULBD surgery. The UB-ULBD group had a significantly shorter operation time (P < 0.05). The facet was significantly better preserved in the UB-ULBD group than in the PE-ULBD group, and the angle of ipsilateral facet joint resection in the UE-ULBD group was significantly smaller (P < 0.05). The ODI score, VAS score and modified Macnab criteria improved postoperatively in both groups. The UB-ULBD group had a 95.08% rate of excellent or good patient outcomes, whereas the PE-ULBD group had a 92.30% rate.
    CONCLUSIONS: Both UB-ULBD and PE-ULBD can provide favourable clinical outcomes when used to treat LSS. UB-ULBD is beneficial because of its shorter operation time, smaller angle of ipsilateral facet joint resection and better facet preservation, making it a viable and safe option for treating LSS while ensuring spinal stability.
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  • 文章类型: Journal Article
    背景:后外侧减压融合内固定是治疗退行性腰椎管狭窄症(DLSS)的常用手术方法。本研究旨在评估减压期间保留单侧小关节的一部分对患者手术结果和长期康复的影响。
    方法:本研究分析了2022年1月至2023年3月进行单级L4/5后外侧减压融合手术的73例伴有双侧下肢神经症状的DLSS患者。根据接受的手术类型将患者分为两组:A组包括31例接受神经减压而不保留小关节的患者,B组由42例接受神经减压并保留一侧部分小关节的患者组成。定期进行后续评估,包括术后立即进行临床和放射学评估,此后3个月和12个月。通过回顾性图表回顾记录关键患者信息。
    结果:两组中的大多数患者都经历了良好的手术结局。然而,4例出现并发症。值得注意的是,在后续行动中,B组术后1年椎体间融合术疗效明显(P<0.05),随着椎间融合器沉降减少和术后椎间盘高度丢失减慢的趋势。此外,B组术后住院时间明显减少(P<0.05)。
    结论:在严格遵守手术适应症的情况下,腰椎后外侧融合手术,在神经减压期间单侧保留部分小关节,可以为患者提供更大的好处。
    BACKGROUND: Posterolateral decompression and fusion with internal fixation is a commonly used surgical approach for treating degenerative lumbar spinal stenosis (DLSS). This study aims to evaluate the impact of preserving a portion of the unilateral facet joint during decompression on surgical outcomes and long-term recovery in patients.
    METHODS: This study analyzed 73 patients with DLSS accompanied by bilateral lower limb neurological symptoms who underwent single-level L4/5 posterolateral decompression and fusion surgery from January 2022 to March 2023. Patients were categorized into two groups based on the type of surgery received: Group A comprised 31 patients who underwent neural decompression without facet joint preservation, while Group B consisted of 42 patients who underwent neural decompression with preservation of partial facet joints on one side. Regular follow-up evaluations were conducted, including clinical and radiological assessments immediately postoperatively, and at 3 and 12 months thereafter. Key patient information was documented through retrospective chart reviews.
    RESULTS: Most patients in both groups experienced favorable surgical outcomes. However, four cases encountered complications. Notably, during follow-up, Group B demonstrated superior 1-year postoperative interbody fusion outcomes (P < 0.05), along with a trend towards less interbody cage subsidence and slower postoperative intervertebral disc height loss. Additionally, Group B showed significantly reduced postoperative hospital stay (P < 0.05).
    CONCLUSIONS: Under strict adherence to surgical indications, the posterior lateral lumbar fusion surgery, which preserves partial facet joint unilaterally during neural decompression, can offer greater benefits to patients.
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  • 文章类型: Journal Article
    背景技术串联椎管狭窄(TSS)是指在两个不同的解剖区域的椎管变窄。症状可由脊髓型颈椎病或腰椎管狭窄引起。因此,确定需要手术的症状解剖水平可能会带来挑战。我们试图确定与更好的患者报告结果相关的手术方法。材料和方法使用国际疾病分类第9版和第10版代码查询信息管理系统,以识别在2011年至2020年期间接受TSS同时或分期减压手术的患者。患者记录进行了审查,以收集有关年龄的数据,性别,合并症,手术方法,修改后的日本骨科协会(mJOA)评分,和并发症。mJOA是一种经过验证的复合评估,用于量化术后神经状况。使用多变量回归模型来确定与更好的术后神经功能恢复相关的因素。结果纳入分析队列的42例患者中,33例(78.6%)同时行颈椎和腰椎减压术,9人(21.4%)接受了分期减压(颈椎,腰椎)。病人的年龄,性别,合并症条件,和美国麻醉医师协会的水平在两组之间相似。此外,同时减压与更高的失血量相关(676.97vs.584.44mL)和输血需求增加(259.09vs.111.11mL)与分阶段减压相比。此外,同时进行减压的患者术后并发症发生率较高(10vs.1;p=0.024)。值得注意的是,两组术后mJOA评分均有改善;然而,分期组的改善更为明显(mJOA评分:15.16%[±2.18]vs.16.56%[±1.59])。关于后续访问,接受分期减压的患者恢复率较高(mJOA评分:78.20%[±24.45]vs.59.75%[±25.05])。结论患者的病史和检查结果是决定手术决策的主要因素。我们的研究表明,在TSS分期减压中,术后mJOA评分略高,康复率和并发症少。
    Introduction  Tandem spinal stenosis (TSS) refers to the narrowing of the spinal canal at two distinct anatomic areas. Symptoms can present due to either cervical myelopathy or lumbar stenosis. Consequently, determining the symptomatic anatomical levels requiring surgery can pose a challenge. We sought to identify the surgical approach associated with better patient-reported outcomes. Materials and Methods  The Information Management System was queried using the International Classification of Diseases Ninth and Tenth Edition codes to identify patients who underwent simultaneous or staged decompression surgery for TSS between 2011 and 2020. Patient records were reviewed to collect data on age, sex, comorbidities, surgical approach, modified Japanese Orthopedic Association (mJOA) score, and complications. The mJOA is a validated composite assessment used to quantify postoperative neurological status. Multivariable regression models were utilized to identify factors associated with better postoperative neurological recovery. Results  Among 42 patients included in the analytical cohort, 33 (78.6%) underwent simultaneous cervical and lumbar decompression, while 9 (21.4%) underwent staged decompression (cervical followed by lumbar). The patient\'s age, sex, comorbid conditions, and American Society of Anesthesiologists level were similar between the two groups. Furthermore, simultaneous decompression was associated with higher blood loss (676.97 vs. 584.44 mL) and an increased need for transfusion (259.09 vs. 111.11 mL) compared with staged decompression. Moreover, patients who underwent simultaneous decompression experienced a higher number of postoperative complications (10 vs. 1; p  = 0.024). Notably, postoperative mJOA scores improved in both groups; however, the improvement was more pronounced in the staged group (mJOA score: 15.16% [ ± 2.18] vs. 16.56% [ ± 1.59]). On follow-up visits, patients who underwent staged decompression showed better recovery rates (mJOA score: 78.20% [ ± 24.45] vs. 59.75% [ ± 25.05]). Conclusion  The patient\'s clinical history and examination findings should be the main determinants of surgical decision-making. Our study showed a slightly higher postoperative mJOA score and a recovery rate with fewer complications in staged decompression of TSS.
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  • 文章类型: Journal Article
    传统的开放式椎板切除术由于其积极的结果,长期以来一直被认为是腰椎中央狭窄的重要手术选择之一。然而,新的方法已经成为替代方案,包括全内镜和双门内镜椎板切除术。因此,有必要比较与这些手术方法相关的结局.这项前瞻性多中心试验,于2019年2月开始,比较了三种腰椎中央狭窄症手术方法的结果:开放椎板切除术(OPEN),单孔内窥镜检查(UNIPORT),和双入口内窥镜检查(BIPORT)。在来自七个中心的115名参与者中,为期一年的随访评估实验室,放射学,和临床结果。尽管所有组都显示出足够的减压和临床改善,OPEN组的背痛视觉模拟量表(VAS)评分改善较少(p<0.05),多数实验室指标术后显著升高.此外,与内镜组相比,OPEN组多裂肌横截面积显著减少(p<0.001).每种手术技术产生相似的临床结果和硬脑膜间隙扩张。然而,内镜手术与更好的肌肉保护和更好的背部疼痛缓解相关.内窥镜手术是治疗腰椎中央狭窄的常规椎板切除术的合理选择。这项试验在CRIS(临床研究信息服务,KCT0004355)。
    Conventional open laminectomy has long been considered one of the important surgical options for lumbar central stenosis owing to its positive outcomes. However, newer approaches have emerged as alternatives, including full-endoscopic and biportal endoscopic laminectomy. Therefore, a comparison of the outcomes that are associated with each of these surgical methods is warranted. This prospective multicenter trial, initiated in February 2019, compared the outcomes of three lumbar central stenosis surgical approaches: open laminectomy (OPEN), uniportal endoscopy (UNIPORT), and biportal endoscopy (BIPORT). Among 115 participants from seven centers, one-year follow-ups assessed laboratory, radiological, and clinical outcomes. Despite all groups showing adequate decompression and clinical improvement, the OPEN group exhibited less improvement in Visual analog scale (VAS) for back pain scores (p < 0.05) and significant postoperative increases in most laboratory markers. Furthermore, the OPEN group experienced a significant decrease in multifidus muscle cross-sectional area compared to endoscopic groups (p < 0.001). Each surgical techniques produced similar clinical outcomes and dural space expansion. However, endoscopic surgery was associated with better muscle preservation and better relief of back pain. Endoscopic surgery is a reasonable alternative to conventional laminectomy for treating lumbar central stenosis.This trial was registered on CRIS (Clinical Research Information Service, KCT0004355).
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  • 文章类型: Journal Article
    术前硬膜外类固醇注射(ESI)与术后颈椎和腰椎手术感染(SSI)之间是否存在统计学上的显着关联?
    对接受择期颈椎或腰椎手术的18岁以上患者进行了系统综述和荟萃分析。将术前接受ESI手术的患者与未接受ESI手术的患者进行比较。我们评估了术后SSI发生率的差异。电子文献数据库的检索时间为2022年10月。包括同行评审的出版物,其中包括有关硬膜外暴露和非暴露的原始数据。病例报告,案例系列,摘要,社论,或不包括原始数据的出版物被排除.从收集的原始数据计算奇数比(OR)。采用RevManv5固定效应模型进行Meta分析。
    我们确定了16篇文章。当不控制从ESI到手术的手术类型和时间时,术前ESI和术后SSI之间有统计学意义的OR.当在手术后30天或31-90天内进行ESI时,这种关联仍然存在。仅评估颈椎手术时未发现关联。证据被指定为“中等”等级。
    我们的分析表明,依赖于时间,术前ESI和术后腰椎SSI之间可能存在统计学显著关联.然而,产生的OR,虽然具有统计学意义,在临床上足够接近1.0,效果大小是“小”。“在适当的临床环境中治疗ESI所需的数量是,在最坏的情况下,3.需要伤害的数量,意味着在脊柱手术前任何时候接受ESI然后发展为SSI的患者数量,111名患者最终,根据我们的研究结果,ESI的手术保留潜力超过了SSI风险.
    UNASSIGNED: Is there a statistically significant association between preoperative epidural steroid injections (ESI) and postoperative cervical and lumbar spinal surgery infections (SSI)?
    UNASSIGNED: A systematic review and meta-analysis was completed of patients 18 years or older who underwent elective cervical or lumbar spinal surgery. Those who underwent surgery with preoperative ESI were compared to those without. We assessed for differences in postoperative SSI incidence. Electronic literature databases were searched through October 2022. Peer-reviewed publications that included raw data regarding epidural exposure and non-exposure were included. Case reports, case series, abstracts, editorials, or publications that did not include raw data were excluded. Odd\'s ratios (OR) were calculated from the raw data collected. Meta-analysis was done using RevMan v5 with a fixed effects model.
    UNASSIGNED: We identified 16 articles for inclusion. When not controlling for the type of surgery and time from ESI to surgery, there was a statistically significant OR between preoperative ESI and postoperative SSI. The association persisted when the ESI was performed within 30 days or 31-90 days of the surgery. No association was discovered when evaluating only cervical spine surgeries. The evidence is assigned a \"moderate\" GRADE rating.
    UNASSIGNED: Our analysis shows a small, time-dependent, statistically significant association between preoperative ESI and postoperative lumbar SSI may exist. However, the OR produced, while statistically significant, are close enough to 1.0 that clinically, the effect size is \"small.\" The number needed to treat for an ESI in the appropriate clinical setting is, at worst, 3. The number needed to harm, meaning the number of patients who undergo an ESI at any time before their spine surgery and then develop a SSI, is 111 patients. Ultimately, the surgical sparing potential from an ESI outweighs the SSI risk based on our findings.
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  • 文章类型: Journal Article
    关于椎板切除术后复发的危险因素有很多报道。一些外科医生使用单侧和双侧融合来为腰椎提供足够的稳定性。然而,它的力量,安全,对年轻患者的有效性并不广为人知。因此,本研究旨在比较年轻腰椎管狭窄症患者采用单侧和双侧固定的椎板切除术和不进行椎间融合术的单纯椎板切除术的手术方法。
    通过方便抽样选择了符合腰椎管狭窄症手术条件的90例患者,随机分为三组:无固定椎板切除术(A),单侧固定的椎板切除术(B),和双侧固定(C)。疼痛,功能性残疾,生活质量,复发性椎间盘,相邻节段疾病(ASD),术后6个月评估和比较三组间的融合率。使用SPSS版本16对数据进行分析。
    手术后六个月,双侧组的功能残疾平均得分明显高于其他组(12.92(3.30)比5.52(1.91)和4.30(1.84),P<0.05)。此外,在双侧组中观察到术后疼痛的最高平均评分(4.33(0.70)vs1.81(0.68)和1.63(0.56),P<0.05)。单侧组的生活质量平均得分明显高于其他组(87.81(5.67)vs68.58(3.08)和56.07(4.04),P<0.05)。两组间融合无显著性差异(P>0.05),复发性椎间盘突出症,和相邻节段疾病。
    单侧固定提供了与双侧固定相同的益处,但具有更小的侵入性和在手术期间和之后最小化其他研究技术的缺点的额外益处。
    UNASSIGNED: There are many reports about the risk factors for recurrence after laminectomy surgery. Some surgeons use unilateral and bilateral fusion to provide sufficient stability to the lumbar spine. However, its strength, safety, and effectiveness in young patients are not widely known. Therefore, this study was conducted to compare surgical methods of laminectomy with unilateral and bilateral fixation and laminectomy alone without interbody fusion in young patients with lumbar spinal stenosis.
    UNASSIGNED: 90 patients eligible for lumbar spinal stenosis surgery were selected through convenience sampling and randomly divided into three groups: laminectomy without fixation (A), laminectomy with unilateral fixation (B), and bilateral fixation (C). Pain, functional disability, quality of life, recurrent disc, adjacent segment disease (ASD), and fusion rate were evaluated and compared among the three groups six months post-surgery. The data were analyzed using SPSS version 16.
    UNASSIGNED: Six months after surgery, the mean score of functional disability in the bilateral group was significantly higher than the other groups (12.92 (3.30) vs 5.52 (1.91) and 4.30 (1.84), P < 0.05). Also, the highest mean score of pain after surgery was observed in the bilateral group (4.33 (0.70) vs 1.81(0.68) and 1.63(0.56), P < 0.05). The mean score of quality of life in the unilateral group was significantly higher than the other groups (87.81 (5.67) vs 68.58 (3.08) and 56.07 (4.04), P < 0.05). No significant difference was observed between the groups (P > 0.05) regarding fusion, recurrent disc herniation, and adjacent segment disease.
    UNASSIGNED: Unilateral fixation provides the same benefits as bilateral fixation but has the additional benefits of being less invasive and minimizing the disadvantages of other investigated techniques during and after surgery.
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  • 文章类型: Journal Article
    背景:腰大肌的形态测量分析已显示出在各种手术领域中预测术后发病率的实用性,但是它在预测接受多水平腰椎融合手术的老年患者并发症中的有用性尚未被研究。本研究旨在探讨腰大肌主要参数是否是老年患者术后早期并发症的独立危险因素。
    方法:纳入接受多节段腰椎融合术治疗退行性腰椎管狭窄症(DLSS)的患者。在计算机断层扫描图像上以三种方式在腰椎3/4椎间盘水平测量腰大肌:腰大肌质量指数,平均肌肉衰减,和腰大肌的形态变化。使用Clavien-Dindo分类系统和综合并发症指数(CCI)对早期并发症进行分级。CCI≥26.2提示严重并发症。Logistic回归分析独立危险因素。
    结果:这项回顾性研究回顾了108例患者(平均年龄70.9岁,男女比例1.8:1)。72.2%的患者出现并发症,同种异体输血最常见(66.7%),接着是伤口感染,急性心力衰竭(各2.8%)。13.9%的患者发生严重并发症。经过多元回归分析,腰大肌衰减程度最低的患者发生术后早期并发症(OR:3.327,95%CI1.134~9.763,p=0.029)和严重并发症(OR:6.964,95%CI1.928~25.160,p=0.003)的几率较高.
    结论:腰大肌衰减可作为老年患者多水平腰椎融合术治疗DLSS术后早期并发症的预测指标。
    BACKGROUND: Morphometric analysis of the psoas major muscle has shown utility in predicting postoperative morbidity in various surgical fields, but its usefulness in predicting complications in elderly patients undergoing multilevel lumbar fusion surgery has not been studied. The study aimed to investigate if psoas major parameters are independent risk factors of early postoperative complication among elderly patients.
    METHODS: Patients who underwent multilevel lumbar fusion for degenerative lumbar spinal stenosis (DLSS) were included. The psoas major was measured at the lumbar 3/4 intervertebral disc level in three ways on computed tomography image: psoas muscle mass index, mean muscle attenuation, and morphologic change of the psoas major. Early complications were graded using the Clavien-Dindo classification system and the Comprehensive complication index (CCI). A CCI ≥ 26.2 indicated severe complications. Logistic regression was performed to identify independent risk factors.
    RESULTS: This retrospective study reviewed 108 patients (mean age 70.9 years, female to male ratio 1.8:1). Complications were observed in 72.2% of patients, with allogeneic blood transfusion being the most frequent (66.7%), followed by wound infection, acute heart failure (2.8% each). Severe complications occurred in 13.9% of patients. After multivariable regression analysis, those in the lowest psoas muscle attenuation tertile had higher odds of experiencing early postoperative complications (OR: 3.327, 95% CI 1.134-9.763, p = 0.029) and severe complications (OR: 6.964, 95% CI 1.928-25.160, p = 0.003).
    CONCLUSIONS: The psoas muscle attenuation can be used as a predictor of early postoperative complications in elderly patients undergoing multilevel lumbar fusion surgery for DLSS.
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  • 文章类型: Journal Article
    背景:经手术治疗的腰椎管狭窄症或神经根型颈椎病患者报告约有三分之二的患者病情好转。机器学习的进步和大型数据集的实用性使脊柱手术中的预后预测模型得以发展。这项试验调查了是否使用术后结果预测模型,对话支持,与目前的实践相比,可以改变患者报告的结果和满意度。
    方法:这是一个前瞻性的,多中心临床试验。将对转诊至脊柱诊所的颈椎神经根病或腰椎管狭窄症患者进行资格筛选。参与者将在招募时和12个月的随访时进行基线评估。对话支持将用于所有参与者,然后将它们放入手术或非手术治疗臂中,取决于患者和外科医生之间的决定。手术治疗组将根据颈神经根病或腰椎管狭窄症的诊断进行单独研究。将手术组和非手术组与从Swespine登记册中检索的回顾性匹配对照组进行比较,没有使用对话支持。主要结果指标是手术治疗组中有关腿部/手臂疼痛的总体评估。次要结果指标包括患者满意度,Oswestry残疾指数(ODI),EQ-5D,和疼痛的数字等级量表(NRS)。在非手术治疗组中,主要结局指标是EQ-5D和死亡率,作为选择偏差分析的一部分。
    结论:这项研究的结果可能为使用先进的数字决策工具是否可以改变患者报告的术后结局提供证据。
    背景:该试验于4月17日在ClinicalTrials.gov进行了回顾性注册,2023年,NCT05817747。
    方法:1.
    方法:临床多中心试验。
    BACKGROUND: Patients surgically treated for lumbar spinal stenosis or cervical radiculopathy report improvement in approximately two out of three cases. Advancements in Machine Learning and the utility of large datasets have enabled the development of prognostic prediction models within spine surgery. This trial investigates if the use of the postoperative outcome prediction model, the Dialogue Support, can alter patient-reported outcome and satisfaction compared to current practice.
    METHODS: This is a prospective, multicenter clinical trial. Patients referred to a spine clinic with cervical radiculopathy or lumbar spinal stenosis will be screened for eligibility. Participants will be assessed at baseline upon recruitment and at 12 months follow-up. The Dialogue Support will be used on all participants, and they will thereafter be placed into either a surgical or a non-surgical treatment arm, depending on the decision made between patient and surgeon. The surgical treatment group will be studied separately based on diagnosis of either cervical radiculopathy or lumbar spinal stenosis. Both the surgical and the non-surgical group will be compared to a retrospective matched control group retrieved from the Swespine register, on which the Dialogue Support has not been used. The primary outcome measure is global assessment regarding leg/arm pain in the surgical treatment group. Secondary outcome measures include patient satisfaction, Oswestry Disability Index (ODI), EQ-5D, and Numeric Rating Scales (NRS) for pain. In the non-surgical treatment group primary outcome measures are EQ-5D and mortality, as part of a selection bias analysis.
    CONCLUSIONS: The findings of this study may provide evidence on whether the use of an advanced digital decision tool can alter patient-reported outcomes after surgery.
    BACKGROUND: The trial was retrospectively registered at ClinicalTrials.gov on April 17th, 2023, NCT05817747.
    METHODS: 1.
    METHODS: Clinical multicenter trial.
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  • 文章类型: Journal Article
    背景:经椎间孔硬膜外注射(TEI)可以缓解症状,并有助于维持腰椎神经根疼痛患者的身体功能和生活质量。我们的目标是为因腰椎间盘突出症(LDH)或单级椎管狭窄症(LSS)而患有单侧腰椎神经根性疼痛的患者,建立TEI后患者预后的预测模型。次要目的是评估LDH和LSS患者之间的短期患者预后差异,心理变量与患者预后之间的关联,额外注射的速度,手术和并发症,并探讨TEI的短期成本效益。
    方法:本研究设计为多中心,观察,荷兰两家大型地区医院的前瞻性队列研究。诊断为LDH或LSS继发的单侧腰椎神经根性疼痛的患者,与MRI检查结果一致。沿着常规护理途径转介TEI的人,有资格参与研究。将包括总共388名LDH或LSS患者。一组预定义的人口统计,临床和放射学变量将用作模型中的预测因子.主要结果指标是腿部疼痛的数值评定量表(NRS)。次要结果指标包括背痛,身体机能,感知到的恢复,疼痛应对策略,焦虑和抑郁以及镇痛药和物理治疗的使用。患者将在基线时进行评估,医治后2周和6周。NRS腿部疼痛和Likert感知恢复数据将用作广义线性混合模型中的因变量,用于预测TEI结果。通过引导重采样对性能进行内部验证(解释变化)。治疗前后6周的成本效益将通过决策分析模型进行。
    结论:当保守治疗不足时,严重的腰椎神经根性疼痛患者通常需要额外的治疗。TEI可以缓解症状。目前,无法预测个别患者对这种治疗的反应性.这项研究旨在探索预测因子,这些预测因子可以区分TEI后将和将不会有积极结果的患者。该信息可以支持针对该患者组的治疗策略。
    背景:本研究于2020年9月1日在ClinicalTrials.gov数据库注册,注册号为NCT04540068。
    BACKGROUND: Transforaminal epidural injections (TEI) can alleviate symptoms and help to maintain physical functioning and quality of life in patients with lumbar radicular pain. We aim to develop a prediction model for patient outcome after TEI in patients suffering from unilateral lumbar radicular pain due to lumbar disc herniation (LDH) or single-level spinal stenosis (LSS). The secondary aim is to estimate short-term patient outcome differences between LDH and LSS patients, the association between psychological variables and patient outcome, the rate of additional injections, surgery and complications, and to explore the short-term cost-effectiveness of TEI.
    METHODS: This study is designed as a multi-centre, observational, prospective cohort study in two large regional hospitals in the Netherlands. Patients diagnosed with unilateral lumbar radicular pain secondary to LDH or LSS and congruent with MRI findings, who are referred for TEI along usual care pathways, are eligible for study participation. A total of 388 patients with LDH or LSS will be included. A pre-defined set of demographic, clinical and radiological variables will be used as the predictors in the model. The primary outcome measure is the Numerical Rating Scale (NRS) for leg pain. Secondary outcome measures include back pain, physical functioning, perceived recovery, pain coping strategies, anxiety and depression and use of analgesics and physical therapy. Patients will be evaluated at baseline, 2 weeks and 6 weeks after treatment. NRS leg pain and Likert perceived recovery data will be used as the dependent variables in a generalized linear mixed model for prediction of TEI outcome, with internal validation of performance (explained variation) by bootstrap resampling. Cost-effectiveness for a period of 6 weeks prior to and after treatment will be performed with decision-analytic modelling.
    CONCLUSIONS: Patients with severe lumbar radicular pain often request additional treatment when conservative care is insufficient. TEI can offer relief of symptoms. Currently, it is not possible to predict responsiveness to this treatment for individual patients. This study is designed to explore predictors that can differentiate between patients that will and will not have a positive outcome after TEI. This information may support treatment strategies for this patient group.
    BACKGROUND: This study is registered at ClinicalTrials.gov database under registry number NCT04540068 on September 1, 2020.
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