Skull Fractures

颅骨骨折
  • 文章类型: Journal Article
    颞骨(TB)骨折经常伴有颅内损伤。本研究旨在分析合并颅内损伤与内耳功能变化的关系。包括对侧耳,结核病骨折患者。94例患者(平均年龄:35.6±18.7岁,包括M:F=67:27)诊断为单侧TB骨折。骨传导(BC)阈值,单词识别得分(WRS),根据颅内损伤比较前庭功能的变化,集中在对侧。观察到各种类型的颅内损伤(67.9%)。其中,研究发现创伤性脑损伤(TBI)与侵犯耳囊的骨折之间存在显著关联.TBI患者骨折侧的BC阈值显着下降。此外,在TBI患者的对侧证实了明显更差的BC阈值,颅内出血(ICH),和内容伤害。随访BC阈值没有改善或不同,无论高剂量的类固醇给药。在每种颅内损伤的存在下,双热热量测试中的初始WRS和管麻痹没有显着差异。脑脊液空间和淋巴空间压力的同时波动被认为是潜在的潜在机制。在TBI患者的对侧证实了明显更差的BC阈值,contrecoup伤,ICH,以及TBI患者的骨折侧。
    Temporal bone (TB) fractures are frequently accompanied by intracranial injury. This study aimed to analyze combined intracranial injuries in relation to functional changes in the inner ear, including those of the contralateral ear, in patients with TB fractures. Ninety-four patients (mean age: 35.6 ± 18.7 years, M : F=67 : 27) diagnosed with unilateral TB fracture were included. Bone conduction (BC) threshold, word recognition score (WRS), and changes in vestibular function were compared based on intracranial injuries, focusing on the contralateral side. Various types of intracranial injuries were observed (67.9%). Among these, a significant association between traumatic brain injury (TBI) and otic capsule-violating fractures was noted. The BC threshold on the fractured side significantly deteriorated in patients with TBI. Additionally, a significantly worse BC threshold was confirmed on the contralateral side in patients with TBI, intracranial hemorrhage (ICH), and contrecoup injury. The follow-up BC threshold did not improve or differ, regardless of high-dose steroid administration. The initial WRS and canal paresis in the bithermal caloric test were not significantly different in the presence of each intracranial injury. Concurrent fluctuations in the pressure of the cerebrospinal fluid space and perilymphatic space were speculated to be the potential underlying mechanisms. A significantly worse BC threshold was confirmed on the contralateral side of patients with TBI, contrecoup injury, ICH, and on fracture sides of patients with TBI.
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  • 文章类型: Journal Article
    人的头部有时会经历冲击载荷,导致颅骨骨折或其他伤害,导致需要开颅手术.颅骨成形术是涉及用自体骨或同种异体材料替换移除部分的程序。虽然钛由于其优异的性能和生物相容性而传统上是颅骨植入物的首选材料,它的局限性促使人们寻找替代材料。这项研究旨在探索钛的替代材料用于颅骨植入物,以解决钛植入物的局限性并改善颅骨成形术过程的性能。用颅骨植入物重建了一个有缺陷的头骨的3D模型,并且使用各种坚硬和柔软的材料(例如氧化铝,氧化锆,羟基磷灰石,氧化锆增强PMMA,和PMMA)在2000N冲击力下作为钛的替代品。与钛植入物相比,发现氧化铝和氧化锆植入物可减少颅骨和大脑的应力和应变。然而,PMMA植入物显示出在当前负载条件下可能导致颅骨损伤。此外,PMMA和羟基磷灰石植入物容易骨折。尽管有这些发现,所有植入物均未超出大脑的拉伸和压缩应力以及应变的极限。与PMMA植入物相比,氧化锆增强的PMMA植入物还显示出减少颅骨和大脑上的应力和应变。氧化铝和氧化锆有望作为钛的替代品用于生产颅骨植入物。钛的替代植入材料的使用具有通过克服与钛植入物相关的限制来增强颅骨重建的成功的潜力。
    The human head can sometimes experience impact loads that result in skull fractures or other injuries, leading to the need for a craniectomy. Cranioplasty is a procedure that involves replacing the removed portion with either autologous bone or alloplastic material. While titanium has traditionally been the preferred material for cranial implants due to its excellent properties and biocompatibility, its limitations have prompted the search for alternative materials. This research aimed to explore alternative materials to titanium for cranial implants in order to address the limitations of titanium implants and improve the performance of the cranioplasty process. A 3D model of a defective skull was reconstructed with a cranial implant, and the implant was simulated using various stiff and soft materials (such as alumina, zirconia, hydroxyapatite, zirconia-reinforced PMMA, and PMMA) as alternatives to titanium under 2000N impact forces. Alumina and zirconia implants were found to reduce stresses and strains on the skull and brain compared to titanium implants. However, PMMA implants showed potential for causing skull damage under current loading conditions. Additionally, PMMA and hydroxyapatite implants were prone to fracture. Despite these findings, none of the implants exceeded the limits for tensile and compressive stresses and strains on the brain. Zirconia-reinforced PMMA implants were also shown to reduce stresses and strains on the skull and brain compared to PMMA implants. Alumina and zirconia show promise as alternatives to titanium for the production of cranial implants. The use of alternative implant materials to titanium has the potential to enhance the success of cranial reconstruction by overcoming the limitations associated with titanium implants.
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  • 文章类型: Journal Article
    为了确定与持续性脑脊液漏相关的颌面部骨折的患病率,并评估其对我们中心连续治疗患者临床结局的影响。
    这是一项回顾性横断面研究。对超过11年的患者的医疗记录进行年龄分析,性别,损伤的病因,受伤和到医院就诊之间的持续时间,面部骨折的类型及其治疗方法,为控制脑脊液渗漏而进行的治疗,和并发症(S)。计算描述性和双变量统计量。
    总的来说,对1473例患者进行了评估,非手术治疗5天后,66例(4.5%)出现与持续性CSF渗漏相关的颅面损伤。男性(92.5%,P=0.0000)和21至30岁年龄组(59.1%,P=0.01)占优势。最常见(68.2%)的骨折组合类型是LeFortI,II和III,NOE,颧骨复合体和下颌骨。脑脊液漏最常见的临床表现仅是鼻漏,66.7%的患者(P=0.001)。
    这项研究表明,与持续性脑脊液漏相关的颌面部骨折的患病率较低,4.5%的患者出现持续性CSF漏,84.9%的患者在治疗各种颌面骨折后治愈。
    UNASSIGNED: To determine the prevalence of maxillofacial fractures associated with persistent CSF leak, and to assess its bearing on clinical outcomes of consecutive patients managed at our centre.
    UNASSIGNED: This was a retrospective cross-sectional study. The medical records of patients over 11-year period were analysed for age, gender, etiology of injuries, duration between injury and presentation to the hospital, types of facial fracture and their treatments, treatment done to control CSF leak, and complication(s). Descriptive and bivariate statistics were computed.
    UNASSIGNED: Overall, 1473 patients were evaluated, 66 (4.5%) presented with craniofacial injuries associated with persistent CSF leak after 5 days of non-surgical treatment. Males (92.5%, P= 0.0000) and those in the 21 to 30 years age group (59.1 %, P=0.01) were predominant. The most common (68.2%) type of fracture combination was Le Fort I, II and III, NOE, zygomatic complex and mandible. The commonest clinical presentation of CSF leak was rhinorrhea only, in 66.7% of patients (P= 0.001).
    UNASSIGNED: This study shows that the prevalence of maxillofacial fractures associated with persistent CSF leak was low, which was 4.5% of patients that presented with persistent CSF leak and 84.9% of the cases resolved after treatment of the various maxillofacial fractures.
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  • 文章类型: Journal Article
    创伤仍然是一岁以上儿童死亡的主要原因。机动休闲交通工具(RC)增加了小儿创伤的另一个潜在原因。这项研究旨在确定在RC中添加电动机对小儿损伤和颅面骨折的严重程度和频率的影响。
    儿科创伤信息是在2012年至2021年之间从国家电子伤害监测系统(NEISS)数据库获得的。人口统计,受伤原因,诊断,并收集了事件叙述。使用双变量和多变量回归分析来确定与严重损伤相关的损伤因素。
    检查了一百五十万五十九次相遇;113,905(7.1%)与儿科RC有关,其中5354(5.4%)与电动机有关。14.3%的伤害与踏板车有关,18.6%的滑板,自行车占54.2%,对其他RC的影响为12.9%。年龄差异显著,性别,种族,头盔的使用,重伤,RC模式之间的颅面骨折。RC使用者更容易发生面部骨折(OR2.12;95CI2.01,2.23;p<.001),并且涉及严重损伤(OR1.42;95CI1.38,1.46;p<.001)。与他们的自行同行相比,电动滑板车(OR2.24;95CI1.86,2.69;p<.001)而非电动滑板(OR1.01;95CI0.88,1.17;p=0.88)更有可能造成严重伤害。头盔使用与较少的严重伤害相关(OR0.5;95CI0.46,0.54;p<.001),面部骨折(OR0.48;95CI0.41,0.55;p<.001),颅骨骨折(OR0.13;95CI0.09,0.17;p<.001)。
    在RC中增加电动机会大大增加小儿颅面骨折和严重受伤的风险。
    3.
    UNASSIGNED: Trauma remains the leading cause of death for children over a year old. Motorized recreational conveyances (RCs) adds another potential cause of pediatric trauma. This study aims to determine the impact of adding electric motors to RCs on the severity and frequency of pediatric injuries and craniofacial fractures.
    UNASSIGNED: Pediatric trauma information was obtained from the National Electronic Injury Surveillance System (NEISS) database between 2012 and 2021. Demographics, injury cause, diagnoses, and incident narrative were collected. Bivariate and multivariate regression analyses were used to determine injury factors associated with serious injuries.
    UNASSIGNED: One million five hundred ninety-six thousand five hundred fifty-nine encounters were examined; 113,905 (7.1%) were related to pediatric RCs and 5354 (5.4%) of those involved RCs with electric motors. 14.3% of injuries were related to scooters, 18.6% to skateboards, 54.2% to bicycles, and 12.9% to other RCs. There were significant differences in age, sex, race, helmet use, serious injuries, and craniofacial fractures between RC modalities. RC users were more likely to develop facial fractures (OR 2.12; 95%CI 2.01, 2.23; p < .001) and be involved in serious injuries (OR 1.42; 95%CI 1.38, 1.46; p < .001). Compared to their self-propelled counterparts, motorized scooters (OR 2.24; 95%CI 1.86, 2.69; p < .001) but not motorized skateboards (OR 1.01; 95%CI 0.88, 1.17; p = 0.88) were more likely to cause serious injuries. Helmet use was associated with fewer serious injuries (OR 0.5; 95%CI 0.46, 0.54; p < .001), facial fractures (OR 0.48; 95%CI 0.41, 0.55; p < .001), and skull fractures (OR 0.13; 95%CI 0.09, 0.17; p < .001).
    UNASSIGNED: The addition of electric motors to RCs significantly increases the risk of pediatric craniofacial fractures and serious injuries.
    UNASSIGNED: 3.
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  • 文章类型: Journal Article
    目的:评估各种额窦骨折(FSF)的患病率,并检查这些骨折之间的关系,治疗类型,和潜在的并发症。
    方法:在沙特国王医疗城进行了一项回顾性研究,利雅得,沙特阿拉伯。该研究分析了2011-2021年诊断和接受FSF治疗的患者的记录。排除缺少文档或处理不完整的文件。检索到的数据包括:患者年龄,性别,类型,地点,治疗,和FSF的并发症。数据由社会科学统计软件包进行分析,23.0版使用描述性统计和卡方检验。
    结果:共72例,男性占94.4%,女性占5.6%。道路交通事故是创伤的常见原因(91%)。59.7%的额窦骨折为单侧骨折,80.6%的病例伴有其他损伤。前台骨折所占比例最大(58.3%),其次是前后表(37.5%)。进行的外科手术为闭塞(23.9%),头颅和闭塞(23.9%),仅固定(52.2%)。术后并发症分为:神经系统(22.2%),眼科(15.3%),感染(2.8%),畸形(16.7%)。在这些类别中,前表和后表的百分比最高。
    结论:额窦骨折大多需要手术治疗(63.9%),术后并发症尤其发生在神经系统和眼科。我们建议对并发症和不同类型的闭塞材料的关联进行研究。
    OBJECTIVE: To assess the prevalence of various frontal sinus fractures (FSF) and examine the relationships between these fractures, types of treatments, and potential complications.
    METHODS: A retrospective study was carried out in King Saud Medical City, Riyadh, Saudi Arabia. The study analyzed the records of patients who were diagnosed and treated with FSF from 2011-2021. Files with missing documents or incomplete treatment were excluded. The retrieved data includes: patients age, gender, types, locations, treatment, and complications of FSF. Data was analyzed by the statistical Package for the Social Sciences Statistics, version 23.0 using descriptive statistics and Chi-square test.
    RESULTS: A total of 72 cases were included, 94.4% males and 5.6% females. Road traffic accidents were the common cause of trauma (91%). Frontal sinus fractures were unilateral in 59.7% and associated other injuries in 80.6% of cases. Anterior table fractures were the largest proportion (58.3%), followed by anterior and posterior table (37.5%). The carried out surgical procedures were obliteration (23.9%), cranialization and obliteration (23.9%), and fixation only (52.2%). The post-operative complications were categorized into; neurological (22.2%), ophthalmic (15.3%), infection (2.8%), and deformity (16.7%). Anterior and posterior table had the highest percentage among these categories.
    CONCLUSIONS: Frontal sinus fractures were mostly required surgical treatment (63.9%) and post-operative complications occurred especially the neurological and ophthalmic. We recommend studies on the association of complications and different types of obliteration materials.
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  • 文章类型: Journal Article
    背景:这项荟萃分析旨在对全身麻醉(GA)和局部麻醉(LA)在鼻骨骨折(NBFs)患者治疗中的作用进行头对头比较。
    方法:PubMed,Embase,和WebofScience进行了全面搜索。包括调查GA和LA在NBFs管理中的临床结果的研究。计算具有相应的95%置信区间(CI)的集合优势比(OR)。评估了纳入研究之间的异质性。评估纳入研究的偏倚风险。
    结果:本荟萃分析包括8项研究。美容结果的合并OR,残余间隔畸形,需要进一步手术,患者对麻醉程序的满意度,患者对手术结果的满意度为0.70(95%CI0.18,2.64;z=-0.53,p=0.5957),1.11(95%CI0.37,3.30;z=0.18,p=0.8558),1.19(95%CI0.65,2.20;z=0.56,p=0.5760),1.57(95%CI0.92,2.69;z=1.65,p=0.0982),和1.00(95%CI0.55,1.80;z=-0.00,p=0.9974)。
    结论:在操作NBFs患者时,GA和LA之间的临床结果没有显着差异,麻醉方法的选择应基于方法的耐受性和鼻部骨折的严重程度。
    BACKGROUND: This meta-analysis aimed to perform a head-to-head comparison of the role of general anesthesia (GA) and local anesthesia (LA) in the management of patients with nasal bone fractures (NBFs).
    METHODS: PubMed, Embase, and Web of Science were comprehensively searched. Studies investigating the clinical outcomes of GA and LA in the management of NBFs were included. Pooled odds ratios (OR) with the respective 95% confidence intervals (CIs) were calculated. Heterogeneity between the included studies was evaluated. The risk of bias in the included studies was assessed.
    RESULTS: Eight studies were included in this meta-analysis. The pooled ORs for cosmetic results, residual septal deformity, the need for further surgery, patients\' satisfaction with the anesthesia procedure, and patients\' satisfaction with the surgery results were 0.70 (95% CI 0.18, 2.64; z = - 0.53, p = 0.5957), 1.11 (95% CI 0.37, 3.30; z = 0.18, p = 0.8558), 1.19 (95% CI 0.65, 2.20; z = 0.56, p = 0.5760), 1.57 (95% CI 0.92, 2.69; z = 1.65, p = 0.0982), and 1.00 (95% CI 0.55, 1.80; z = - 0.00, p = 0.9974).
    CONCLUSIONS: Insignificant difference on clinical outcomes was observed between GA and LA in the manipulation of patients with NBFs, and the choice of anesthetic approach should be based on the tolerability of the methods and the severity of nasal fractures.
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  • 文章类型: Case Reports
    该报告描述了一名患有外伤性右颞顶颅骨骨折并伴有慢性右硬膜下血肿的患者,该患者接受了n-BCA的右脑膜中动脉栓塞术,在此期间观察到大脑中动脉的颞前分支的直接填充。
    The report describes a patient who presented with traumatic right temporoparietal calvarial fracture with chronic right subdural haematoma who underwent right middle meningeal artery embolisation with n-BCA during which direct filling of an anterior temporal branch of the middle cerebral artery was observed.
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  • 文章类型: Journal Article
    背景:0-4岁的儿童因创伤性脑损伤(TBI)而急诊(ED)就诊率最高;跌倒是主要原因。小于2岁的婴儿在跌倒后更有可能维持颅骨骨折。
    目的:本研究调查了0-4个月婴儿因跌倒相关颅骨骨折的护理者行为和相关产品。
    方法:数据来自2001-2017年国家电子伤害监测系统-所有伤害计划。检查了0-4个月大的因跌倒相关颅骨骨折就诊的ED婴儿的病例叙述,以规范跌倒前的护理人员行为。产品代码确定了坠落位置和涉及的产品类型(例如,地板,bed,或楼梯)。所有国家的估计都是加权的。
    结果:在2001年至2017年之间,0-4个月的非致命性跌倒相关颅骨骨折婴儿有超过27,000次ED访视(加权估计)。大多数年龄小于2个月(46.7%),男性(54.4%)。跌倒主要发生在家中(69.9%),需要住院治疗(76.4%)。编码的主要照顾者行动涉及放置(58.6%),下降(22.7%),并携带一名婴儿(16.6%)。地板表面是最常见的产品(在24.0%的案例中提到)。
    结论:跌倒相关的颅骨骨折是婴儿的健康和发育问题,强调在受伤时进行全面评估以更好地了解成人行为的重要性。调查结果表明,有必要制定预防信息,包括安全携带和安置婴儿。
    BACKGROUND: Children aged 0-4 years have the highest rate of emergency department (ED) visits for traumatic brain injury (TBI); falls are the leading cause. Infants younger than 2 years are more likely to sustain a fractured skull after a fall.
    OBJECTIVE: This study examined caregiver actions and products associated with ED visits for fall-related fractured skulls in infants aged 0-4 months.
    METHODS: Data were analyzed from the 2001-2017 National Electronic Injury Surveillance System-All Injury Program. Case narratives of infants aged 0-4 months who visited an ED for a fall-related skull fracture were examined to code caregiver actions preceding the fall. Product codes determined fall location and product type involved (e.g., flooring, bed, or stairs). All national estimates were weighted.
    RESULTS: There were more than 27,000 ED visits (weighted estimate) of infants aged 0-4 months for a nonfatal fall-related fractured skull between 2001 and 2017. Most were younger than 2 months (46.7%) and male (54.4%). Falls occurred primarily in the home (69.9%) and required hospitalization (76.4%). Primary caregiver actions coded involved placing (58.6%), dropping (22.7%), and carrying an infant (16.6%). Floor surfaces were the most common product (mentioned in 24.0% of the cases).
    CONCLUSIONS: Fall-related fractured skulls are a health and developmental concern for infants, highlighting the importance of a comprehensive assessment at the time of the injury to better understand adult actions. Findings indicated the need to develop prevention messages that include safe carrying and placement of infants.
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  • 文章类型: Journal Article
    目的:关于口腔颌面外科医疗事故索赔原因的研究很少。这项研究的目的是调查颅面骨折相关医疗事故索赔中永久性伤害的原因和患病率。
    方法:设计并实施了一项回顾性注册研究。包括所有主诉和诊断为面部或颅骨骨折的患者。主要结果是存在永久性伤害,预测变量是投诉的原因。卡方检验用于统计显著性的估计。
    结果:正确诊断的延迟是医疗事故索赔的主要原因(63.2%),在23.1%的人口中发现了永久性伤害。总人口中面部骨折占82.4%。65.3%(n=98)的面部创伤与延迟诊断有关(p<0.001)。诊断延迟的患者(71.4%)比没有诊断的患者(60.7%,p=0.299)。
    结论:颅面外伤的索赔与诊断不足有关,和未诊断的面部骨折可导致高比率的永久性伤害。建议进行系统的临床评估和面部创伤专家咨询,以早期正确诊断并改善颅面创伤患者的治疗。
    OBJECTIVE: Research on reasons for malpractice claims in oral and maxillofacial surgery is scarce. The aim of this study was to investigate the causes and prevalence of permanent harm among craniofacial fracture related malpractice claims.
    METHODS: A retrospective register study was designed and implemented. All patients with a complaint and a diagnosis of facial or cranial fracture were included. The main outcome was the presence of permanent harm, and the predictor variable was the cause of complaint. Chi-square test was used for estimation of statistical significance.
    RESULTS: Delay in correct diagnosis was the leading cause of malpractice claims (63.2%), and permanent harm was found in 23.1% of the population. 82.4% of injuries were facial fractures in total population. 65.3% (n = 98) of facial trauma were related with delayed diagnostics (p < 0.001). Permanent harm was more frequent in patients with delayed diagnosis (71.4%) than those without (60.7%, p = 0.299).
    CONCLUSIONS: Claims of craniofacial trauma are related with under-diagnostics, and un-diagnosed facial fracture can lead to a high rate of permanent harm. Systematic clinical evaluation and facial trauma specialist consultation is recommended to set early correct diagnosis for and improve treatment of craniofacial trauma patients.
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  • 文章类型: Journal Article
    目的:本研究的目的是分析成人和儿童患者颞骨骨折的患病率和并发症,这些患者在紧急情况下被评估为颅面部创伤。
    方法:对在紧急情况下调查的294例连续成人和儿童颅面外伤患者的CT扫描进行回顾性盲法分析。比较了两个人群的研究结果。将待命居民的初步报告与回顾性分析进行了比较,这是由两名有经验的读者一致进行的,并作为参考标准。
    结果:CT显示116/294(39.5%)患者中有126处骨折,尽管仅在70/294(23.8%)中临床怀疑骨折;p<0.05。骨折是纵向的,横向和混合在69.5%,10.3%和19.8%的病例,分别。大多数骨折为保留耳部骨折(95.2%)。外耳道受累,72.2%的人存在听骨链和面神经周围的骨结构,8.7%和6.3%的病例,分别。在18.3%和17.5%的病例中,颞骨骨折扩展到静脉窦/颈静脉孔和颈动脉管,分别。儿童血管损伤(颈动脉夹层和静脉血栓形成)比成人更常见(13.6%比5.3%);观察到的差异没有达到统计学意义。79.5%的颞骨骨折患者既有脑损伤,也有面部骨骼和颅骨的骨折。脑损伤在成人(90.4%)比儿童(63.6%)更常见,p=0.001。尽管值班居民可靠地检测到颞骨骨折(灵敏度=92.8%),他们经常错过与创伤相关的听骨脱位(敏感度=27.3%)。
    结论:颞骨骨折和相关并发症在颅面外伤患者中很常见,需要彻底寻找;儿童和成人的相关损伤模式略有不同。
    OBJECTIVE: The purpose of this study was to analyze the prevalence of and complications resulting from temporal bone fractures in adult and pediatric patients evaluated for cranio-facial trauma in an emergency setting.
    METHODS: A retrospective blinded analysis of CT scans of a series of 294 consecutive adult and pediatric patients with cranio-facial trauma investigated in the emergency setting was conducted. Findings were compared between the two populations. Preliminary reports made by on-call residents were compared with the retrospective analysis, which was performed in consensus by two experienced readers and served as reference standard.
    RESULTS: CT revealed 126 fractures in 116/294 (39.5%) patients, although fractures were clinically suspected only in 70/294 (23.8%); p < 0.05. Fractures were longitudinal, transverse and mixed in 69.5%, 10.3% and 19.8% of cases, respectively. Most fractures were otic-sparing fractures (95.2%). Involvement of the external auditory canal, ossicular chain and the osseous structures surrounding the facial nerve was present in 72.2%, 8.7% and 6.3% of cases, respectively. Temporal bone fractures extended into the venous sinuses/jugular foramen and carotid canal in 18.3% and 17.5% of cases, respectively. Vascular injuries (carotid dissection and venous thrombosis) were more common in children than in adults (13.6% versus 5.3%); however, the observed difference did not reach statistical significance. 79.5% of patients with temporal bone fractures had both brain injuries and fractures of the facial bones and cranial vault. Brain injuries were more common in adults (90.4%) than in children (63.6%), p = 0.001. Although on-call residents reliably detected temporal bone fractures (sensitivity = 92.8%), they often missed trauma-associated ossicular dislocation (sensitivity = 27.3%).
    CONCLUSIONS: Temporal bone fractures and related complications are common in patients with cranio-facial trauma and need to be thoroughly looked for; the pattern of associated injuries is slightly different in children and in adults.
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