PubMed

pubmed
  • 文章类型: Journal Article
    调查研究可以在大型队列中收集有关个人观点的信息。可能是流行病学,专注的态度或知识。目前,文献中缺乏对神经外科医生抽样的调查研究的评估。本研究旨在突出特点,质量,以及发表在神经外科文献中最具影响力的调查研究的引文预测因子。使用PubMed和谷歌学者,对被引用次数最多的50份调查研究出版物进行了鉴定和审查.与物品特征有关的数据,检索参与者和问卷。对研究的质量和引文模式进行了评估。文章年龄中位数和发表期刊影响因子(IF)分别为15.5岁和2.82岁。来自美国的研究人员首次撰写了32篇(64%)文章,而28篇(56%)研究集中在特定的疾病管理上。参与者的中位数和反应率分别为222%和51%,分别。18篇(36%)文章提供了完整版本的问卷。只有四篇(8%)文章报告了问卷的有效性。调查报告的总体质量被认为是公平的(基于五个参数的良好评级,一个参数中的公平评分,四个参数的分级较差)。引用次数中位数为111。引文分析表明,参与者数量,文章年龄(≥15.5岁),和问卷类别(手术并发症)是引文数量的重要预测因素。引用率不受应答率或期刊IF的影响。总之,神经外科文献中的高影响力调查出版物被中等程度地引用并且质量相当.他们的引文数量不受回应率的影响,但受出版年龄的积极影响,参与人数,以及新颖的数据或调查类别中提出的问题。调查是有价值的研究形式,需要广泛的规划,时间,和努力,以产生有意义的结果。提高对可能影响引文的因素的认识可能对那些希望进行调查研究的人有用。
    Survey research enables the gathering of information on individual perspectives in a large cohort. It can be epidemiological, attitude or knowledge focussed. Assessment of survey studies sampling neurosurgeons is currently lacking in the literature. This study aimed to highlight the characteristics, quality, and citation predictors of the most influential survey research studies published in the neurosurgical literature. Using PubMed and Google Scholar, the 50 most cited survey research publications were identified and reviewed. Data relating to the characteristics of the articles, participants and questionnaires were retrieved. The studies\' quality and citation patterns were assessed. The median articles\' age and publishing journal impact factor (IF) were 15.5 years and 2.82, respectively. Thirty-two (64%) articles were first authored by researchers from the USA while 28(56%) studies were focussed on specific disease management. The median number of participants and response rates were 222 and 51%, respectively. A full version of the questionnaire was provided in 18 (36%) articles. Only four (8%) articles reported validation of the questionnaire. The overall quality of reporting of the surveys was considered fair (based on good grading in five parameters, fair grading in one parameter, and poor grading in four parameters). The median citation number was 111. The citation analysis showed that the participant number, article age (≥15.5 years), and questionnaire category (surgical complications) were significant predictors of citation numbers. The citation rates were not influenced by the response rates or the journal\'s IF. In conclusion, high-impact survey publications in the neurosurgical literature were moderately cited and of fair quality. Their citation numbers were not affected by response rates but were positively influenced by the publication age, number of participants, and by novel data or the questions raised in the survey category. Surveys are valuable forms of research that require extensive planning, time, and effort in order to produce meaningful results. Increasing awareness of the factors that could affect citations may be useful to those who wish to undertake survey research.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Editorial
    科学期刊存在的原因是传播科学知识。目标是不断提高出版内容的质量,增加读者数量。在这个意义上,影响因子是一个指标,可以帮助我们可视化我们期刊质量的提高。为了提高这一影响因素,在最常用的数据库中索引是非常重要的。FarmacéuticosComunitarios在几个索引期刊中被索引,但我们缺少最常用的索引。在过去的一年中,我们要求对最重要的索引进行索引,SCOPUS和Medline。11月,我们获得了SCOPUS的批准,并且即将在Medline上获得批准。9月,我们被编辑标准批准,12月被科学家批准。我们只需要技术标准就可以出现在Medline及其在线版本PubMed中。我们正在研究它,很可能在一年内我们将在PubMed中索引。
    The reason for existence of a scientific journal is to disseminate knowledge of science. The objective is a continuous improvement in the quality of what is published and an increase in the number of readers. In this sense, the impact factor is an indicator that helps us visualize the improvement in the quality of our journal. To improve this impact factor, indexing in the most used databases is very important.Farmacéuticos Comunitarios is indexed in several index journals but we were missing the most used ones. In this last year we have requested indexing in the most important ones, SCOPUS and Medline. In November we received SCOPUS approval and are close to getting it on Medline. In September we were approved by the editorial criteria and in December by the scientists. We only need the technical criteria to be able to appear in Medline and in its online version PubMed. We are working on it and it is very likely that within a year we will be indexed in PubMed.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    生物医学关系的自动识别是对已发表文献的非结构化文本中包含的信息进行语义理解的重要步骤。BioCreativeVIII的BioRED曲目旨在通过向参与者提供BioRED-BC8语料库来促进此类方法的发展,为疾病手动策划的1000个PubMed文档集合,基因/蛋白质,化学品,细胞系,基因变异,和物种,以及它们之间的成对关系,这是疾病基因,化学基因,疾病变异,基因-基因,化学疾病,化学化学,化学变体,和变体-变体。此外,关系分为以下语义类别:正相关,负相关,绑定,转换,药物相互作用,比较,共同处理,和协会。与大多数以前公开的语料库不同,所有关系都在文档级别表达,而不是在句子级别表达,因此,将实体标准化为标准化词汇表的相应概念标识符,即,疾病和化学物质被标准化为MeSH,基因(和蛋白质)到国家生物技术信息中心(NCBI)基因,NCBI分类学的物种,细胞系到天龙,和单核苷酸多态性数据库的基因/蛋白质变体。最后,每个注释的关系被归类为\'novel\',这取决于它是一个新的发现或实验验证在出版物中表达。这种区别有助于将新发现与提供已知事实和/或背景知识的同一文本中的其他关系区分开来。BioRED-BC8语料库使用先前的600篇PubMed文章的BioRED语料库作为训练数据集,并包括一组新发布的400篇文章作为挑战的测试数据。所有测试文章都是由国家医学图书馆的专家生物清洁工手动注释的BioCreativeVIII挑战,使用原始注释指南,其中每篇文章都在三轮注释过程中进行双重注释,直到所有策展人之间达成完全协议。本手稿详细介绍了BioRED-BC8语料库作为生物医学命名实体识别和关系提取的关键资源的特征。使用这个新资源,我们已经证明了生物医学文本挖掘算法开发的进步。数据库URL:https://codalab。Lisn.upsaclay.fr/竞赛/16381.
    The automatic recognition of biomedical relationships is an important step in the semantic understanding of the information contained in the unstructured text of the published literature. The BioRED track at BioCreative VIII aimed to foster the development of such methods by providing the participants the BioRED-BC8 corpus, a collection of 1000 PubMed documents manually curated for diseases, gene/proteins, chemicals, cell lines, gene variants, and species, as well as pairwise relationships between them which are disease-gene, chemical-gene, disease-variant, gene-gene, chemical-disease, chemical-chemical, chemical-variant, and variant-variant. Furthermore, relationships are categorized into the following semantic categories: positive correlation, negative correlation, binding, conversion, drug interaction, comparison, cotreatment, and association. Unlike most of the previous publicly available corpora, all relationships are expressed at the document level as opposed to the sentence level, and as such, the entities are normalized to the corresponding concept identifiers of the standardized vocabularies, namely, diseases and chemicals are normalized to MeSH, genes (and proteins) to National Center for Biotechnology Information (NCBI) Gene, species to NCBI Taxonomy, cell lines to Cellosaurus, and gene/protein variants to Single Nucleotide Polymorphism Database. Finally, each annotated relationship is categorized as \'novel\' depending on whether it is a novel finding or experimental verification in the publication it is expressed in. This distinction helps differentiate novel findings from other relationships in the same text that provides known facts and/or background knowledge. The BioRED-BC8 corpus uses the previous BioRED corpus of 600 PubMed articles as the training dataset and includes a set of newly published 400 articles to serve as the test data for the challenge. All test articles were manually annotated for the BioCreative VIII challenge by expert biocurators at the National Library of Medicine, using the original annotation guidelines, where each article is doubly annotated in a three-round annotation process until full agreement is reached between all curators. This manuscript details the characteristics of the BioRED-BC8 corpus as a critical resource for biomedical named entity recognition and relation extraction. Using this new resource, we have demonstrated advancements in biomedical text-mining algorithm development. Database URL: https://codalab.lisn.upsaclay.fr/competitions/16381.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Case Reports
    库提供对数据库的访问,这些数据库具有嵌入到服务中的自动引用功能;但是,在人文和社会科学数据库中,这些自动引用按钮的准确性不是很高。
    这个案例比较了两个生物医学数据库,OvidMEDLINE和PubMed,看看两者是否足够可靠,可以自信地推荐给学生在写论文时使用。总共评估了60篇引文,每个引文生成器引用30次,基于2010年至2020年PubMed排名前30位的文章。
    OvidMEDLINE的错误率高于PubMed,但两个数据库平台均未提供无错误引用。自动引用工具不可靠。所检查的60篇引文中有0篇是100%正确的。图书馆员应继续建议学生不要仅依赖这些生物医学数据库中的引文生成器。
    UNASSIGNED: Libraries provide access to databases with auto-cite features embedded into the services; however, the accuracy of these auto-cite buttons is not very high in humanities and social sciences databases.
    UNASSIGNED: This case compares two biomedical databases, Ovid MEDLINE and PubMed, to see if either is reliable enough to confidently recommend to students for use when writing papers. A total of 60 citations were assessed, 30 citations from each citation generator, based on the top 30 articles in PubMed from 2010 to 2020.
    UNASSIGNED: Error rates were higher in Ovid MEDLINE than PubMed but neither database platform provided error-free references. The auto-cite tools were not reliable. Zero of the 60 citations examined were 100% correct. Librarians should continue to advise students not to rely solely upon citation generators in these biomedical databases.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    心理健康状况,比如抑郁症,焦虑,和压力相关的疾病,通常很难使用传统方法进行诊断和监测。唾液生物标志物提供了一个有希望的替代由于其非侵入性的性质,易于收集,以及反映与心理健康相关的实时生理变化的潜力。这项文献计量分析检查了95项关于心理健康压力生物标志物的临床试验,2003年至2024年出版。该领域的特点是广泛合作和全球参与,涉及73种期刊的593位作者和出版物。尽管每年的出版率一致,2011年、2014年和2018年的显着增长表明研究兴趣不断增长。美国的研究成果领先,其次是澳大利亚,德国,和日本,精神神经内分泌学是最著名的杂志。共现分析确定了九个研究集群,提出了不同的方向,比如压力相关激素的影响,昼夜节律,正念,各种疗法,老化,心理适应机制,运动疗法,焦虑症,和唾液生物标志物上的自主神经系统。关键术语,如“生物标志物/新陈代谢,“和”氢化可的松/新陈代谢,“和”唾液/新陈代谢“是中心,从2012年到2018年有重大活动。该分析强调了对唾液生物标志物在心理健康中的代谢过程和治疗应用的日益关注。这项文献计量分析呼吁关注唾液生物标志物通过非侵入性方法彻底改变心理健康诊断和治疗的潜力,促进跨学科研究,技术进步,和全球健康改善。
    Mental health conditions, such as depression, anxiety, and stress-related disorders, are often difficult to diagnose and monitor using traditional methods. Salivary biomarkers offer a promising alternative due to their non-invasive nature, ease of collection, and the potential to reflect real-time physiological changes associated with mental health. This bibliometric analysis examines 95 clinical trials on stress biomarkers for mental health, published between 2003 and 2024. The field is characterized by extensive collaboration and global participation, involving 593 authors and publications across 73 journals. Despite a consistent annual publication rate, notable increases in 2011, 2014, and 2018 indicate growing research interest. The United States leads in research output, followed by Australia, Germany, and Japan, with Psychoneuroendocrinology being the most prominent journal. Co-occurrence analysis identified nine research clusters, suggesting diverse directions such as the impact of stress-related hormones, circadian rhythms, mindfulness, various therapies, aging, psychological adaptation mechanisms, exercise therapy, anxiety disorders, and the autonomic nervous system on salivary biomarkers. Key terms such as \"biomarkers/metabolism,\" AND \"hydrocortisone/metabolism,\" AND \"saliva/metabolism\" were central, with significant activity from 2012 to 2018. This analysis highlights a growing focus on the metabolic processes and therapeutic applications of salivary biomarkers in mental health. This bibliometric analysis calls attention to the promising potential of salivary biomarkers to revolutionize mental health diagnostics and treatment through non-invasive methods, fostering interdisciplinary research, technological advancements, and global health improvements.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    生物医学和生命科学的出版物数量增长如此之多,以至于很难跟踪新的科学作品,也很难对整个领域的发展进行概述。这里,我们提供了整个生物医学文献语料库的二维(2D)图,基于PubMed数据库中2100万篇英文文章的摘要文本。要将摘要嵌入到2D中,我们使用了大型语言模型PubMedBERT,结合为处理这种大小的样品而定制的t-SNE。我们用我们的图谱研究了COVID-19文献的出现,神经科学学科的演变,机器学习的吸收,学术作者身份中性别失衡的分布,以及收回的造纸厂物品的分配。此外,我们提供了一个交互式网站,可以轻松探索,并将使进一步的见解和促进未来的研究。
    The number of publications in biomedicine and life sciences has grown so much that it is difficult to keep track of new scientific works and to have an overview of the evolution of the field as a whole. Here, we present a two-dimensional (2D) map of the entire corpus of biomedical literature, based on the abstract texts of 21 million English articles from the PubMed database. To embed the abstracts into 2D, we used the large language model PubMedBERT, combined with t-SNE tailored to handle samples of this size. We used our map to study the emergence of the COVID-19 literature, the evolution of the neuroscience discipline, the uptake of machine learning, the distribution of gender imbalance in academic authorship, and the distribution of retracted paper mill articles. Furthermore, we present an interactive website that allows easy exploration and will enable further insights and facilitate future research.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    背景:对基于证据的医疗决策的高质量系统文献综述(SRs)的需求正在增长。SR成本很高,需要高技能审稿人的稀缺资源。已经提出了自动化技术来节省工作量并加快SR工作流程。我们旨在全面概述PubMed索引的SR自动化研究,专注于这些技术在现实世界实践中的适用性。
    方法:2022年11月,我们提取,合并,并在SR自动化上运行了对SR的集成PubMed搜索。全文包括英文同行评审文章,如果他们报告了对SR自动化方法(SSAM)的研究,或自动SR(ASR)。书目分析和知识发现研究被排除在外。记录筛选由单个审阅者进行,全文论文的选择一式两份。我们总结了出版物的细节,自动审查阶段,自动化目标,应用工具,数据源,方法,结果,和谷歌学者对SR自动化研究的引用。
    结果:根据标题和摘要筛选的5321条记录,我们收录了123篇全文,其中SSAM108个,ASR15个。自动化用于搜索(19/123,15.4%),记录筛查(89/123,72.4%),全文选择(6/123,4.9%),数据提取(13/123,10.6%),偏见风险评估(9/123,7.3%),证据综合(2/123,1.6%),证据质量评估(2/123,1.6%),和报告(2/123,1.6%)。11项(8.9%)研究将多个SR阶段自动化。自动记录筛选的性能在SR主题中差异很大。在已发布的ASR中,我们找到了自动搜索的例子,记录筛选,全文选择,和数据提取。在某些ASR中,自动化完全补充了手动审核,以提高灵敏度,而不是节省工作量。在ASR中,自动化详细信息的报告通常是不完整的。
    结论:正在为所有SR阶段开发自动化技术,但现实世界的采用率有限。大多数SR自动化工具以单个SR阶段为目标,在整个SR过程中节省了适度的时间,并且在研究中具有不同的灵敏度和特异性。因此,SR自动化的实际好处仍然不确定。标准化术语,reporting,和研究报告的指标可以增强SR自动化技术在现实世界实践中的采用。
    BACKGROUND: The demand for high-quality systematic literature reviews (SRs) for evidence-based medical decision-making is growing. SRs are costly and require the scarce resource of highly skilled reviewers. Automation technology has been proposed to save workload and expedite the SR workflow. We aimed to provide a comprehensive overview of SR automation studies indexed in PubMed, focusing on the applicability of these technologies in real world practice.
    METHODS: In November 2022, we extracted, combined, and ran an integrated PubMed search for SRs on SR automation. Full-text English peer-reviewed articles were included if they reported studies on SR automation methods (SSAM), or automated SRs (ASR). Bibliographic analyses and knowledge-discovery studies were excluded. Record screening was performed by single reviewers, and the selection of full text papers was performed in duplicate. We summarized the publication details, automated review stages, automation goals, applied tools, data sources, methods, results, and Google Scholar citations of SR automation studies.
    RESULTS: From 5321 records screened by title and abstract, we included 123 full text articles, of which 108 were SSAM and 15 ASR. Automation was applied for search (19/123, 15.4%), record screening (89/123, 72.4%), full-text selection (6/123, 4.9%), data extraction (13/123, 10.6%), risk of bias assessment (9/123, 7.3%), evidence synthesis (2/123, 1.6%), assessment of evidence quality (2/123, 1.6%), and reporting (2/123, 1.6%). Multiple SR stages were automated by 11 (8.9%) studies. The performance of automated record screening varied largely across SR topics. In published ASR, we found examples of automated search, record screening, full-text selection, and data extraction. In some ASRs, automation fully complemented manual reviews to increase sensitivity rather than to save workload. Reporting of automation details was often incomplete in ASRs.
    CONCLUSIONS: Automation techniques are being developed for all SR stages, but with limited real-world adoption. Most SR automation tools target single SR stages, with modest time savings for the entire SR process and varying sensitivity and specificity across studies. Therefore, the real-world benefits of SR automation remain uncertain. Standardizing the terminology, reporting, and metrics of study reports could enhance the adoption of SR automation techniques in real-world practice.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    在对两个医疗电子数据库进行了全面的文献检索后,PubMed和Embase,以及两个引文数据库,WebofScience核心收藏(WoS)和Scopus,我们旨在对医学研究中的医学史文献进行Altmetric和Scientometric分析。
    以下软件工具用于分析从PubMed和Embase数据库中检索到的记录,并进行合作分析,以确定涉及科学医学论文的国家,以及聚类关键词,以揭示未来医学史研究的趋势。这些软件工具(VOSviewer1.6.18和Spss16)允许研究人员可视化文献计量网络,进行统计分析,并识别数据中的模式和趋势。
    我们的分析揭示了来自PubMed的53,771条记录和来自EMBASE数据库的54,405条记录,这些记录在医学史领域由105,286位WoS的撰稿人检索。我们确定了157个在科学医学论文上合作的国家。通过对59,995个关键字进行聚类,我们能够揭示未来医学史研究的趋势。我们的研究结果表明,传统文献计量学和社交媒体指标(如医学史文献中的Altmetric注意力评分)之间存在正相关(p<0.05)。
    在社会科学网络中分享文章的研究成果将增加医学史研究中科学著作的知名度,这是影响文章引用的最重要因素之一。此外,我们对医学领域文献的概述使我们能够识别和检查医学史研究中的空白。
    UNASSIGNED: After conducting a comprehensive literature search of two medical electronic databases, PubMed and Embase, as well as two citation databases, Web of Science Core Collections (WoS) and Scopus, we aimed to conduct an Altmetric and Scientometric analysis of the History of Medicine literature in medical research.
    UNASSIGNED: The following software tools were used for analyzing the retrieved records from PubMed and Embase databases and conducting a collaboration analysis to identify the countries involved in scientific medical papers, as well as clustering keywords to reveal the trend of History of Medicine research for the future. These software tools (VOSviewer 1.6.18 and Spss 16) allowed the researchers to visualize bibliometric networks, perform statistical analysis, and identify patterns and trends in the data.
    UNASSIGNED: Our analysis revealed 53,771 records from PubMed and 54,405 records from EMBASE databases retrieved in the field of History of Medicine by 105,286 contributed authors in WoS. We identified 157 countries that collaborated on scientific medical papers. By clustering 59,995 keywords, we were able to reveal the trend of History of Medicine research for the future. Our findings showed a positive association between traditional bibliometrics and social media metrics such as the Altmetric Attention Score in the History of Medicine literature (p < 0.05).
    UNASSIGNED: Sharing research findings of articles in social scientific networks will increase the visibility of scientific works in History of Medicine research, which is one of the most important factors influencing the citation of articles. Additionally, our overview of the literature in the medical field allowed us to identify and examine gaps in the History of Medicine research.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    使用两个数据库,这项文献计量分析是针对医学院发表的论文进行的,喀土穆大学(FMUK),从2019年到2023年。从SCImago提取了所有苏丹的数据,并从PubMed获得FMUK及其相关研究中心的出版物,地方病研究所,和Mycetoma研究中心.对出版物的分析包括出版物的数量和类型,期刊,以及国家和国际合作评估。FMUK的出版物显示,随着时间的推移,其数量和质量有所改善,受国家和国际合作影响很大的增长。这些伙伴关系已被证明是FMUK研究成果的关键驱动力,加上专业研究机构的宝贵贡献。然而,通过提高支持研究和科学交流的机构能力,研究产出还有改进的空间。《苏丹儿科杂志》就是一个例子,开放获取通过允许建立外围期刊而产生积极影响。
    Using two databases, this bibliometric analysis was done for the papers published by the Faculty of Medicine, University of Khartoum (FMUK), from 2019 to 2023. Data were extracted from SCImago for all Sudan, and from PubMed for the publications by FMUK and its associated research centres, the Institute of Endemic Diseases, and the Mycetoma Research Center. The analysis of publications included the count and type of publications, the journals, and national and international collaboration assessment. The publications from FMUK show improvement over time in number and quality, a growth that is significantly influenced by national and international collaboration. These partnerships have proven to be a key driver of FMUK\'s research output, together with the valuable contributions of the specialized research institutions. However, there is room for improvement in the research output by increasing institutional capacity to support research and scientific communication. The Sudanese Journal of Paediatrics is an example where open access has a positive impact by allowing peripheral journals to be established despite the constraints.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

  • 文章类型: Journal Article
    TIN-X(目标重要性和新颖性eXprerer)是一种交互式可视化工具,用于阐明疾病与潜在药物靶标之间的关联,可在newdrugtargets.org上公开获得。TIN-X使用自然语言处理来识别PubMed内容中的疾病和蛋白质提及,使用先前发布的用于基因/蛋白质和疾病名称的命名实体识别(NER)的工具。从目标中央资源数据库(TCRD)获得目标数据。两个重要指标,新颖性和重要性,是从这些数据计算的,当绘制为对数(重要性)与日志(新颖性),帮助用户在视觉上探索药物靶标的新颖性及其对疾病的重要性。TIN-X版本3.0已通过扩展的数据集进行了显着改进,包括RESTAPI的现代化架构,和改进的用户界面(UI)。数据集已经扩展到不仅包括PubMed出版物标题和摘要,还有全文文章。这导致与TIN-X的先前版本相比大约9倍更多的靶标/疾病关联。此外,包含此扩展数据集的TIN-X数据库现在通过AmazonRDS托管在云中。最近对UI的增强侧重于使用户更直观地找到感兴趣的疾病或药物目标,同时提供新的,可排序的表视图模式与现有的绘图视图模式相伴。UI改进还帮助用户浏览相关的PubMed出版物,以探索和理解TIN-X预测的特定疾病与感兴趣的目标之间的关联的基础。在实施这些升级时,在Web服务器和用户的Web浏览器之间平衡计算资源,以在容纳扩展数据集的同时实现足够的性能。一起,这些进展旨在延长用户可以从TIN-X中受益的持续时间,同时提供扩展的数据集和研究人员可以用来更好地阐明未被研究的蛋白质的新功能。
    TIN-X (Target Importance and Novelty eXplorer) is an interactive visualization tool for illuminating associations between diseases and potential drug targets and is publicly available at newdrugtargets.org. TIN-X uses natural language processing to identify disease and protein mentions within PubMed content using previously published tools for named entity recognition (NER) of gene/protein and disease names. Target data is obtained from the Target Central Resource Database (TCRD). Two important metrics, novelty and importance, are computed from this data and when plotted as log(importance) vs. log(novelty), aid the user in visually exploring the novelty of drug targets and their associated importance to diseases. TIN-X Version 3.0 has been significantly improved with an expanded dataset, modernized architecture including a REST API, and an improved user interface (UI). The dataset has been expanded to include not only PubMed publication titles and abstracts, but also full-text articles when available. This results in approximately 9-fold more target/disease associations compared to previous versions of TIN-X. Additionally, the TIN-X database containing this expanded dataset is now hosted in the cloud via Amazon RDS. Recent enhancements to the UI focuses on making it more intuitive for users to find diseases or drug targets of interest while providing a new, sortable table-view mode to accompany the existing plot-view mode. UI improvements also help the user browse the associated PubMed publications to explore and understand the basis of TIN-X\'s predicted association between a specific disease and a target of interest. While implementing these upgrades, computational resources are balanced between the webserver and the user\'s web browser to achieve adequate performance while accommodating the expanded dataset. Together, these advances aim to extend the duration that users can benefit from TIN-X while providing both an expanded dataset and new features that researchers can use to better illuminate understudied proteins.
    导出

    更多引用

    收藏

    翻译标题摘要

    我要上传

       PDF(Pubmed)

公众号