目的:为了确定使用甲基苯丙胺的数周内精神病症状的风险是否取决于,增加,或独立于,有精神病家族史设计:对13个连续1周的数据(1,370周)进行二次分析。使用风险修正框架来测试每个场景设置:吉朗,卧龙岗和墨尔本,澳大利亚参与者:一项针对甲基苯丙胺依赖治疗的随机对照试验(N=148)的参与者,在入学测量中没有原发性精神障碍:在前一周的精神病症状被定义为在任何简短的精神病评定量表项目上3分以上幻觉,不寻常的思想内容或怀疑。任何(vs.no)使用TimelineFollowback方法评估前一周的甲基苯丙胺使用情况。自我报告的精神病家族史使用精神病诊断访谈结果进行评估:过去一周精神病症状的风险与该周使用甲基苯丙胺(相对风险[RR]2.3,95%置信区间[CI]1.3-4.3)和有精神病家族史(RR2.4,95%CI0.9-7.0);在使用甲基苯丙胺家族史的参与者中,联合风险为4.0(95%)。精神病家族史和甲基苯丙胺使用在预测精神病症状方面没有显著的相互作用(相互作用RR0.795%CI0.3-1.8),但由于这种相互作用(0.2095%CI-1.63-2.03),有一个小的非显著超额风险结论:在依赖甲基苯丙胺的人群中,在使用甲基苯丙胺的几周内,精神病症状的相对风险似乎并不依赖于,也没有增加,有精神病家族史.然而,精神病家族史似乎是导致该人群精神病症状绝对风险的独立危险因素.
To determine whether the risk of psychotic symptoms during weeks of methamphetamine use was dependent on, increased by, or independent of having a family history of psychosis.
Secondary analysis of 13 contiguous 1-week periods of data (1370 weeks). A risk modification framework was used to test each scenario.
Geelong, Wollongong and Melbourne, Australia.
Participants in a randomized controlled trial of treatment for methamphetamine dependence (n = 148) who did not have a primary psychotic disorder on enrolment.
Psychotic symptoms in the previous week were defined as a score of 3+ on any of the Brief Psychiatric Rating Scale items of hallucinations, unusual thought content or suspiciousness. Any (vs no) methamphetamine use in the previous week was assessed using the Timeline Followback method. Self-reported family history of psychosis was assessed using the Diagnostic Interview for Psychosis.
The risk of psychotic symptoms in the past week was independently associated with methamphetamine use in that week (relative risk [RR] = 2.3, 95% CI = 1.3-4.3) and with having a family history of psychosis (RR = 2.4, 95% CI = 0.9-7.0); the joint risk among participants with a family history of psychosis during weeks when they were using methamphetamine was large (RR = 4.0, 95% CI = 2.0-7.9). There was no significant interaction between a family history of psychosis and methamphetamine use in predicting psychotic symptoms (interaction RR = 0.7 95% CI = 0.3-1.8), but there was a small non-significant excess risk due to the interaction (0.20 95% CI = -1.63 to 2.03).
Among people dependent on methamphetamine, the relative risk of psychotic symptoms during weeks of methamphetamine use does not appear to be dependent on, or increased by, having a family history of psychosis. However, a family history of psychosis does appear to be an independent risk factor that contributes to the absolute risk of psychotic symptoms in this population.