背景和目标:Endocan,从激活的内皮分泌,是炎症的关键人物,内皮功能障碍,血管平滑肌细胞的增殖,和血管生成。我们的目的是研究维持性血液透析(HD)患者的内胆与主动脉僵硬度之间的联系。材料和方法:从医疗中心招募HD患者后,它们的基线特征,血液样本,和人体测量学进行评估和记录。使用酶免疫测定试剂盒测定血清内胆水平,颈动脉-股动脉脉搏波传导速度(cfPWV)测量用于评估主动脉僵硬度。结果:共纳入122例HD患者。53例(43.4%)患者诊断为主动脉僵硬,发现年龄较大(p=0.007),糖尿病(p<0.001)和高血压(p=0.030)的患病率较高,收缩压较高(p=0.011),和更高的endocan水平(p<0.001),与他们的同行相比。在多元逻辑回归模型上,发现慢性HD患者的主动脉僵硬度的发展与endocan相关[比值比(OR):1.566,95%置信区间(CI):1.224-2.002,p<0.001],年龄(OR:1.040,95%CI:1.001-1.080,p=0.045),和糖尿病(OR:4.067,95%CI:1.532-10.798,p=0.005),在适当调整混杂因素后(采用糖尿病,高血压,年龄,收缩压,和endocan)。受试者工作特征曲线下面积为0.713(95%CI:0.620-0.806,p<0.001),用于通过血清内皮素水平预测主动脉僵硬度,在2.68ng/mL的最佳截止值(64.15%灵敏度,69.57%的特异性)。经多元线性回归分析,对数变换的内胆被证明是cfPWV的独立预测因子(β=0.405,调整后的R2变化=0.152;p<0.001)。结论:血清endocan水平与cfPWV呈正相关,是慢性HD患者主动脉僵硬度的独立预测因子。
Background and Objectives: Endocan, secreted from the activated endothelium, is a key player in inflammation, endothelial dysfunction, proliferation of vascular smooth muscle cells, and angiogenesis. We aimed to investigate the link between endocan and aortic stiffness in maintenance hemodialysis (HD) patients. Materials and Methods: After recruiting HD patients from a medical center, their baseline characteristics, blood sample, and anthropometry were assessed and recorded. The serum endocan level was determined using an enzyme immunoassay kit, and carotid-femoral pulse wave velocity (cfPWV) measurement was used to evaluate aortic stiffness. Results: A total of 122 HD patients were enrolled. Aortic stiffness was diagnosed in 53 patients (43.4%), who were found to be older (p = 0.007) and have a higher prevalence of diabetes (p < 0.001) and hypertension (p = 0.030), higher systolic blood pressure (p = 0.011), and higher endocan levels (p < 0.001), when compared with their counterparts. On the multivariate logistic regression model, the development of aortic stiffness in patients on chronic HD was found to be associated with endocan [odds ratio (OR): 1.566, 95% confidence interval (CI): 1.224-2.002, p < 0.001], age (OR: 1.040, 95% CI: 1.001-1.080, p = 0.045), and diabetes (OR: 4.067, 95% CI: 1.532-10.798, p = 0.005), after proper adjustment for confounders (adopting diabetes, hypertension, age, systolic blood pressure, and endocan). The area under the receiver operating characteristic curve was 0.713 (95% CI: 0.620-0.806, p < 0.001) for predicting aortic stiffness by the serum endocan level, at an optimal cutoff value of 2.68 ng/mL (64.15% sensitivity, 69.57% specificity). Upon multivariate linear regression analysis, logarithmically transformed endocan was proven as an independent predictor of cfPWV (β = 0.405, adjusted R2 change = 0.152; p < 0.001). Conclusions: The serum endocan level positively correlated with cfPWV and was an independent predictor of aortic stiffness in chronic HD patients.