头颈部鳞状细胞癌(SCC)起源于上消化道的粘膜衬里,包括嘴唇,舌头,鼻咽部,口咽,喉和下咽。在这次审查中,我们总结了目前已知的原发性纤毛在这种疾病的发病机理中的潜在功能。由于初级纤毛代表信号转导的关键细胞结构,并且与细胞增殖有关,了解它们在致癌作用中的作用对于设计新的治疗方法是必要的。这里,我们介绍了头颈部鳞状细胞癌(HNSCC)中纤毛相关信号及其与HNSCC肿瘤发生的可能关联。从这个角度来看,PDGF,EGF,讨论了Wnt和Hh信号传导,因为发现所有这些途径在HNSCC中失调。此外,我们回顾了影响原发性纤毛信号的小分子靶向头颈部鳞状细胞癌的临床潜力。
Squamous cell carcinoma (SCC) of the head and neck originates from the mucosal lining of the upper aerodigestive tract, including the lip, tongue, nasopharynx, oropharynx, larynx and hypopharynx. In this review, we summarise what is currently known about the potential function of primary cilia in the pathogenesis of this disease. As primary cilia represent a key cellular structure for signal transduction and are related to cell proliferation, an understanding of their role in carcinogenesis is necessary for the design of new treatment approaches. Here, we introduce cilia-related signalling in head and neck squamous cell carcinoma (HNSCC) and its possible association with HNSCC tumorigenesis. From this point of view, PDGF, EGF, Wnt and Hh signalling are discussed as all these pathways were found to be dysregulated in HNSCC. Moreover, we review the clinical potential of small molecules affecting primary cilia signalling to target squamous cell carcinoma of the head and neck area.