为了检查髋臼发育不良(AD),在英国生物库(UKB)中,凸轮和/或钳形形态与放射学髋关节骨关节炎(rHOA)和髋部疼痛有关,如果是,观察到骨赘的分布。
使用左髋关节双能X射线吸收法(DXA)扫描的UKB参与者具有α角(AA),横向中心边缘角(LCEA)和关节空间缩小(JSN)自动推导。凸轮和钳形形态,AD使用AA和LCEA定义。手动测量骨赘,并根据JSN和骨赘测量值计算rHOA等级。使用Logistic回归检查这些髋关节形态与rHOA之间的关系,骨赘,JSN,髋部疼痛。
选择了6,807个个体(平均年龄:62.7;3382/3425个男性/女性)。男性的凸轮形态比女性更普遍(分别为15.4%和1.8%)。在男性中,凸轮形态与rHOA相关[OR3.20(95%CI2.41-4.25)],JSN[1.53(1.24-1.88)],和髋臼[1.87(1.48-2.36)],上[1.94(1.45-2.57)]和下[4.75(3.44-6.57)]股骨骨赘,和髋部疼痛[1.48(1.05-2.09)]。在女性中发现了广泛相似的关联,但统计证据较弱。钳形形态和AD均未显示与rHOA或髋部疼痛有任何关联。
凸轮形态主要见于与rHOA和髋部疼痛相关的男性。在男性和女性中,与上股骨头和髋臼相比,凸轮形态与股骨头下骨赘的相关性更强。进一步的研究是合理的,以表征与凸轮形态相关的生物力学干扰,在观察到的骨赘分布的基础上。
To examine whether acetabular dysplasia (AD), cam and/or
pincer morphology are associated with radiographic hip osteoarthritis (rHOA) and hip pain in UK Biobank (UKB) and, if so, what distribution of osteophytes is observed.
Participants from UKB with a left hip dual-energy X-ray absorptiometry (DXA) scan had alpha angle (AA), lateral centre-edge angle (LCEA) and joint space narrowing (JSN) derived automatically. Cam and
pincer morphology, and AD were defined using AA and LCEA. Osteophytes were measured manually and rHOA grades were calculated from JSN and osteophyte measures. Logistic regression was used to examine the relationships between these hip morphologies and rHOA, osteophytes, JSN, and hip pain.
6,807 individuals were selected (mean age: 62.7; 3382/3425 males/females). Cam morphology was more prevalent in males than females (15.4% and 1.8% respectively). In males, cam morphology was associated with rHOA [OR 3.20 (95% CI 2.41-4.25)], JSN [1.53 (1.24-1.88)], and acetabular [1.87 (1.48-2.36)], superior [1.94 (1.45-2.57)] and inferior [4.75 (3.44-6.57)] femoral osteophytes, and hip pain [1.48 (1.05-2.09)]. Broadly similar associations were seen in females, but with weaker statistical evidence. Neither
pincer morphology nor AD showed any associations with rHOA or hip pain.
Cam morphology was predominantly seen in males in whom it was associated with rHOA and hip pain. In males and females, cam morphology was associated with inferior femoral head osteophytes more strongly than those at the superior femoral head and acetabulum. Further studies are justified to characterise the biomechanical disturbances associated with cam morphology, underlying the observed osteophyte distribution.