■所有产生激素的卵巢肿瘤中有近90%是性索基质肿瘤(SCSTs)。卵巢纤维瘤是一种激素无活性的SCST变体。它由主轴组成,椭圆形,圆形细胞产生胶原蛋白,约占所有卵巢肿瘤的4%。在其他SCST中,抑制素B是重要的肿瘤标志物。它是一种异二聚体糖蛋白激素,主要由发育中的卵泡颗粒细胞分泌。高水平的抑制素-B会阻碍卵泡募集,导致育龄妇女闭经。
■在此案例报告中,我们描述了一个罕见的生育年龄女性出现继发性闭经的病例,患有卵巢纤维瘤,产生大量抑制素B。
■尽管已知卵巢纤维瘤的一些病理变体如囊肿-腺-纤维瘤和卵巢纤维-囊瘤分泌抑制素B,良性/纯卵巢纤维瘤很少这样做。
UNASSIGNED: Nearly 90% of all the hormone-producing ovarian tumours are sex cord-stromal tumours (SCSTs). The Ovarian fibroma is a hormonally inactive variant of SCST. It is composed of spindle, oval, round cells producing collagen and accounts for approximately 4% of all ovarian neoplasms. Amongst the other SCSTs, Inhibin B is an important tumour marker. It is a heterodimeric glycoprotein hormone that is secreted primarily by the granulosa cells of the developing follicles. High levels of Inhibin-B can hamper follicular recruitment, leading to amenorrhea in a reproductive age woman.
UNASSIGNED: In this case report, we describe a rare case of a reproductive age female presenting with secondary amenorrhea, having an Ovarian Fibroma, producing massive amounts of Inhibin B.
UNASSIGNED: Although some pathological variants of ovarian fibromas like cyst-adeno-fibroma and ovarian fibro-thecoma are known to secrete inhibin B, benign /pure ovarian fibromas rarely do so.