窄带紫外线B(NB-UVB)(311-312nm)广泛用于皮肤病学疾病,在怀孕期间具有良好的副作用。最近发表的数据显示,NB-UVB可能降低Fitzpatrick皮肤表型I-III的血清叶酸水平,特别是在高剂量下;这可能会使新生儿容易患神经管缺陷。
未经证实:为了比较接受NB-UVB治疗的有色女性和健康育龄女性的血清叶酸水平,以及注意是否观察到随后的并发症,如果有的话。
未经评估:多中心,30名女性(N=30)的横断面研究:15名接受NB-UVB光疗的女性患者以及15岁-,性别-,和皮肤表型匹配的健康志愿者,他们在排除已知会改变血清叶酸浓度的因素后被纳入研究。每周进行2-3次NB-UVB暴露,持续至少8-12周(平均累积NB-UVB剂量±标准偏差[SD]为55±79J/cm2)。
未经证实:NB-UVB暴露和健康对照的平均血清叶酸±SD分别为10.3±4和8.3±3ng/mL,分别。这在两组之间没有统计学上的显著差异(P=0.14)。
UNASSIGNED:小样本量(N=30)和横断面研究类型。
UNASSIGNED:累积NB-UVB暴露与育龄女性皮肤中血清叶酸水平的统计学差异无统计学意义(P>0.05)。性别-,和皮肤表型匹配的健康女性,即使使用相对较高的累积剂量(平均值±SD为55±79J/cm2),也已显示出较轻皮肤表型的血清叶酸水平降低。
Narrowband ultraviolet B (NB-UVB) (311-312 nm) is widely used for dermatological conditions with a favorable side-effect profile during pregnancy. Recently published data showed that NB-UVB might decrease serum folate level in Fitzpatrick skin phenotype I-III, especially at higher doses; this may predispose newborns to neural tube defects.
UNASSIGNED: To compare serum folate levels of skin of color females treated with NB-UVB and healthy females of childbearing age, as well as to note whether subsequent complications have been observed, if any.
UNASSIGNED: Multicenter, cross-sectional study of 30 females (N = 30): 15 female patients undergoing NB-UVB phototherapy as well as 15 age-, gender-, and skin phenotype-matched healthy volunteers who were enrolled into the study after excluding factors known to alter serum folate concentration. NB-UVB exposures were performed 2-3 times a week for at least 8-12 weeks (mean cumulative NB-UVB dose ± standard deviation [SD] was 55 ± 79 J/cm2).
UNASSIGNED: Mean serum folate ± SD in NB-UVB exposed and healthy controls were 10.3 ± 4 and 8.3 ± 3 ng/mL, respectively. This was not a statistically significant difference between the 2 groups (P = .14).
UNASSIGNED: Small sample size (N = 30) and a cross-sectional study type.
UNASSIGNED: Cumulative NB-UVB exposure is not associated with a statistically significant difference in serum folate level (P > .05) in skin of color females of childbearing age in comparison to age-, gender-, and skin phenotype-matched healthy females, even with the relatively higher cumulative doses (mean ± SD was 55 ± 79 J/cm2) that have been shown to reduce serum folate level in lighter skin phenotypes.