UNASSIGNED: The purpose of this study was to clarify the panoramic image differences of cleft alveolus patients with or without a cleft palate, with emphases on the visibility of the line formed by the junction between the nasal septum and nasal floor (the upper line) and the appearances of the maxillary lateral incisor.
UNASSIGNED: Panoramic radiographs of 238 patients with cleft alveolus were analyzed for the visibility of the upper line, including clear, obscure or invisible, and the appearances of the maxillary lateral incisor, regarding congenital absence, incomplete growth, delayed eruption and medial inclination. Differences in the distribution ratio of these visibility and appearances were verified between the patients with and without a cleft palate using the chi-square test.
UNASSIGNED: There was a significant difference in the visibility distribution of the upper line between the patients with and without a cleft palate (p<0.05). In most of the patients with a cleft palate, the upper line was not observed. In the unilateral cleft alveolus patients, the medial inclination of the maxillary lateral incisor was more frequently observed in patients with a cleft palate than in patients without a cleft palate.
UNASSIGNED: Two differences were identified in panoramic appearances. The first was the disappearance (invisible appearance) of the upper line in patients with a cleft palate, and the second was a change in the medial inclination on the affected side maxillary lateral incisor in unilateral cleft alveolus patients with a cleft palate.

OBJECTIVE: Unilateral temporomandibular joint ankylosis with jaw deformity (UTMJAJD) may require simultaneous total joint prosthesis (TJP) reconstruction, sagittal split ramus (SSRO), and Le Fort I osteotomies. The purpose of this study was to evaluate outcomes in patients treated with these procedures.
METHODS: Patients diagnosed UTMJAJD between 2016 and 2018 were selected for the study. Mandible-first procedure was performed after ankylosis release with TJP on the ankylosed side and SSRO on the contralateral side. Le Fort I osteotomy with and without genioplasty was lastly performed. Maximal incisor opening (MIO), facial symmetry, and jaw and condyle stability were compared before, after operation, and during follow-ups.
RESULTS: Seven patients were included in the study. Their average chin deviation was 9.5 ± 4.2 mm, and maxillary cant was 5.1 ± 3.0°. After operation, jaw deformity significantly improved, with chin deviation corrected 7.6 ± 4.1 mm (p = 0.015) and advanced 5.9 ± 2.5 mm (p = 0.006). After an average follow-up of 26.6 ± 17.1 months, MIO significantly increased from 11.4 ± 9.3 to 35.7 ± 2.6 mm (p = 0.000). The occlusion was stable with no significant positional or rotational changes of the jaw (p > 0.05). There was no obvious condylar resorption during follow-ups.
CONCLUSIONS: Simultaneous TJP reconstruction, SSRO, and Le Fort I osteotomy are reliable and effective methods for the treatment of UTMJAJD.

Crocodile tear syndrome (CTS) is a late complication of facial nerve palsy characterized by unilateral lacrimation in response to gustatory stimulation. We present 2 cases of patients diagnosed with CTS after recovering from unilateral idiopathic facial nerve palsy. Both patients underwent transconjunctival lacrimal gland incobotulinumtoxinA injection, with doses of 5-16 units. The patients were seen in clinic for post-treatment follow-up at 2 weeks, 3 months, and 6 months. Outcomes were measured by treatment efficacy and adverse drug effects. Following treatment, both patients reported resolution of gustatory lacrimation. The patient treated with 16 U experienced transient ptosis and diplopia following injection, whereas the patient treated with 5-7.5 U experienced no adverse effects.

Jaw deformity diagnosis requires objective tests. Current methods, like cephalometry, have limitations. However, recent studies have shown that machine learning can diagnose jaw deformities in two dimensions. Therefore, we hypothesized that a multilayer perceptron (MLP) could accurately diagnose jaw deformities in three dimensions (3D).
Examine the hypothesis by focusing on anomalous mandibular position. We aimed to: (1) create a machine learning model to diagnose mandibular retrognathism and prognathism; and (2) compare its performance with traditional cephalometric methods.
An in-silico experiment on deidentified retrospective data. The study was conducted at the Houston Methodist Research Institute and Rensselaer Polytechnic Institute. Included were patient records with jaw deformities and preoperative 3D facial models. Patients with significant jaw asymmetry were excluded.
The tests used to diagnose mandibular anteroposterior position are: (1) SNB angle; (2) facial angle; (3) mandibular unit length (MdUL); and (4) MLP model.
The resultant diagnoses: normal, prognathic, or retrognathic.
None.
A senior surgeon labeled the patients\' mandibles as prognathic, normal, or retrognathic, creating a gold standard. Scientists at Rensselaer Polytechnic Institute developed an MLP model to diagnose mandibular prognathism and retrognathism using the 3D coordinates of 50 landmarks. The performance of the MLP model was compared with three traditional cephalometric measurements: (1) SNB, (2) facial angle, and (3) MdUL. The primary metric used to assess the performance was diagnostic accuracy. McNemar\'s exact test tested the difference between traditional cephalometric measurement and MLP. Cohen\'s Kappa measured inter-rater agreement between each method and the gold standard.
The sample included 101 patients. The diagnostic accuracy of SNB, facial angle, MdUL, and MLP were 74.3, 74.3, 75.3, and 85.2%, respectively. McNemar\'s test shows that our MLP performs significantly better than the SNB (P = .027), facial angle (P = .019), and MdUL (P = .031). The agreement between the traditional cephalometric measurements and the surgeon\'s diagnosis was fair. In contrast, the agreement between the MLP and the surgeon was moderate.
The performance of the MLP is significantly better than that of the traditional cephalometric measurements.

EDSS1, a syndrome characterized by ectodermal dysplasia-syndactyly, is inherited in an autosomal recessive manner due to mutations in the NECTIN4/PVRL4 gene. Clinical manifestations of the syndrome include defective nail plate, sparse to absent scalp and body hair, spaced teeth with enamel hypoplasia, and bilateral cutaneous syndactyly in the fingers and toes. Here, we report a consanguineous family of Kashmiri origin presenting features of EDSS1. Using whole exome sequencing, we found a recurrent nonsense mutation (NM_030916: c.181C > T, p.(Gln61 ∗)) in the NECTIN4 gene. The variant segregated perfectly with the disorder within the family. The candidate variant was absent in 50 in-house exomes pertaining to other disorders from the same population. In addition to the previously reported clinical phenotype, an upper lip cleft was found in one of the affected members as a novel phenotype that is not reported by previous studies in EDSS1 patients. Therefore, the study presented here, which was conducted on the Kashmiri population, is the first to document a NECTIN4 mutation associated with the upper lip cleft as a novel phenotype. This finding broadens the molecular and phenotypic spectrum of EDSS1.

UNASSIGNED: In class III, skeletal patients with high plane angle, counterclockwise rotation of maxillomandibular units is necessary. The study was aimed to evaluate the long-term stability of the change of mandibular plane in patients with class III deformity.
UNASSIGNED: This is a retrospective longitudinal clinical study. Patients with class III skeletal deformity and high plane angles who underwent maxillary advancement and superior repositioning with mandibular set back were studied. The change of mandibular plane (MP) was predictive factors of the study. Age, gender, the amount of movement of the maxillary advancement, and mandibular set back following orthognathic surgeries were variables. The amount of relapse at the A and B points 12 months after orthognathic surgeries was outcomes of the study. Pearson correlation test was used to determine any correlation between relapse at the A and B points following bimaxillary orthognathic surgery.
UNASSIGNED: Fifty-one patients were studied. The mean of MP changes immediately after osteotomies was 4.66 (1.64) degrees. The horizontal relapse at B point 12 months after surgeries was 1.08 (0.81) mm, and the vertical relapse was 1.38 (0.44) mm. There was a correlation between the horizontal and vertical relapse with MP change (P = 0.001).
UNASSIGNED: It seems that the counterclockwise rotation of maxillomandibular units in patients with class III skeletal deformity and high plane angle may be associated with the vertical and horizontal relapse that was noticed at the B point.

OBJECTIVE: The double coronoid process (DCP) is a very unusual feature in patient. The literature, which briefly describes just only one case. Being this a very unusual feature, the aim of the paper is to describe the finding, discuss the anatomic, radiological, and clinical characteristics of a DCP.
METHODS: A 61-year-old-woman with no significant medical history, extraoral and intraoral examination was unremarkable. Following panoramic radiography (PR) for assessment of periodontal support and pre-implant planning suspicious radiopaque area in the mandibular notch on the left side was observed. Cone-Beam Computed Tomography (CBCT) and Magnetic resonance imaging (MRI) were subsequently performed.
RESULTS: No signs and symptoms of syndromes or medical records with a relevant contribution to the DCP existence and the patient denied any type of facial trauma. CBCT image showed the structure found on the PR was indeed a DCP and it was not superimposed on the mandibular notch area, MRI was performed to investigate soft tissue components and temporomandibular joint (TMJ) or other alterations.
CONCLUSIONS: DPC is extremely rare with the only case reported in the literature within the same comparison parameters. In this case images revealed the muscles, articular surfaces and articular disc were well preserved, and no other alterations were found.

Cleft palate-lateral synechiae syndrome (CPLSS) is an extremely rare congenital malformation syndrome with undetermined etiology, characterized by a cleft palate and lateral intraoral synechiae linking the free borders of the palate to the mouth floor. We report a case of a female neonate, admitted for suckling difficulties with a cleft lip and palate associated to multiple lateral intraoral synechiae. Resection of the synechiae allowed oral feeding. Cleft palate-lateral synechiae syndrome is an exceptional syndrome as only seventeen cases have been reported in the literature. Synechiae can be isolated or more frequently in association with other congenital anomalies such as cleft lip and/or palate. These synechiae can cause functional deficits, especially in the respiratory and feeding tracts, language disorders or recurrent otitis. Although it is exceptional, this malformative entity must be known by medical practitioners in order to set up a well-adapted therapeutic protocol.

OBJECTIVE: To investigate the stability and complications of mandibular anterior subapical osteotomy (ASO) in the treatment of bimaxillary dentoalveolar protrusion by way of a retrospective study.
METHODS: One hundred and twenty patients who received orthognathic surgery at a single center between 2008 and 2017 were included. Relapse was assessed by serial tracings of lateral cephalograms which were obtained pre-operatively (T1), within 6 weeks after surgery (T2) and at 2 years after surgery. The changes between T2 and T3 represented stability and were tested using the paired t test. The relationship between the extents of surgical repositioning (T2-T1) and relapse (T3-T2) was investigated using the Pearson correlation coefficient. The associations between the variables and the occurrence of relapse and complications identified the risk factors and were evaluated using the χ2 test or Fisher\'s exact test. When r > 0.80, clinical correlation was considered significant; and statistical significance was set at P < 0.05, while confidence interval was set at 95%.
RESULTS: There was a mean uprighting of L1-MP by 12.7°. At 2 years after surgery, 96.7% of the patients experienced a mean relapse of L1-MP by 2.9°. The extent of surgical repositioning was only weakly correlated with that of relapse and no specific factor that increased the risk of relapse could be identified. The most frequent complications were blood loss requiring transfusion, wound dehiscence or infection, gingival recession, and periodontal bone loss, involving 25.8 to 43.3% of the patients. The remaining complications included tooth root damage, fixation hardware exposure or infection, lingual mucosal laceration, and tooth devitalization. There were no cases of avascular necrosis or nonunion.
CONCLUSIONS: Although relapse occurred in most of the patients after 2 years, the actual extent was small (2.9°) which was not likely to be clinically significant.
BACKGROUND: HKUCTR-2964 CLINICAL RELEVANCE: Although ASO may be valuable in correcting mandibular dentoalveolar protrusion, the procedure brings with it risks and complications and should be reserved for severe deformities.

UNASSIGNED: Patients\' attitudes about their nose changes after orthognathic surgeries. We aimed to evaluate the patient\'s opinion about nasal change and morphologic changes following orthognathic surgery.
UNASSIGNED: This was a cross-sectional study. The sample was derived from the population of patients who underwent orthognathic surgery in the Oral and Maxillofacial Surgery Department of Shahid Beheshti University of Medical Sciences, Tehran, Iran between 2017 and 2019. Subjects who underwent orthognathic surgery were studied. Subjects filled a modified nose evaluation form before and nine months after orthognathic surgery. For objective assessment, the nasolabial angle, nasofrontal angle, nasofacial angle, tip projection, and tip deviation and alar width were evaluated. Sixty-two patients were studied.
UNASSIGNED: Forty (64.5%) patients did not absolutely like their nose before orthognathic surgeries, two (3.2 %) expressed a little satisfaction, 17(27.4%) answered they liked more or less, and three liked very much. Nine months after orthognathic surgeries, 4 (6.5%) patients did not like their nose, nine patients (14.5%) liked a little, 30 (48.4%) liked more or less, and 19 liked very much. Analysis of the data demonstrated a significant difference in patients\' satisfaction with their noses before and nine months after orthognathic surgeries (P<0.001). Patients\' satisfaction nine months after orthognathic surgery was not affected by nasal morphologic changes.
UNASSIGNED: It seems, patients\' satisfaction with their nose improved after orthognathic surgeries. Patients\' attitude was not associated with nasal morphologic changes.