舌后腺分为韦伯和冯·埃伯纳腺。聚糖在唾液腺中起重要作用。虽然聚糖的分布可以解释功能多样性和变异,在发育中的大鼠舌后腺中有许多未知。本研究的目的是通过使用与糖残基结合的凝集素进行组织化学分析,阐明大鼠舌后腺发育与功能之间的关系。在成年大鼠中,拟南芥(PNA),最大甘氨酸(SBA),普通小麦(WGA)与浆液细胞有关,双花多利霍斯(DBA)与粘液细胞有关。在韦伯和冯·埃布纳的腺体中,所有4种凝集素在早期发育中都与浆液细胞结合,但是随着发展的进步,DBA在浆液细胞中消失,只有DBA保留在粘液细胞中。这些结果表明Galβ(1,3)>Galβ(1,4)>Gal,αGalNAc>αGal>βGalNAc,NeuAc>(GalNAc)2-3>>>GlcNAc,和GalNAcα(1,3)存在于发育的早期阶段,但是GalNAcα(1,3)在浆液细胞中消失,成熟后只有GalNAcα(1,3)位于粘液细胞中。这些结果表明,当vonEbner腺体尚未成熟时,韦伯腺体在出生后早期起浆液性腺体的作用。
The posterior lingual glands are classified as Weber and von Ebner glands. Glycans play an important role in salivary glands. Although the distribution of glycans can explain functional diversity and variation, there are many unknowns in the developing rat posterior lingual glands. The purpose of this study was to elucidate the relationship between the development and function of the posterior lingual gland in rats by histochemical analysis using lectins that bind to sugar residues. In adult rats, Arachis hypogaea (PNA), Glycine maximus (SBA), and Triticum vulgaris (WGA) were associated with serous cells and Dolichos biflorus (DBA) with mucous cells. In both Weber\'s and von Ebner\'s glands, all 4 lectins were bound to serous cells in early development, but as development progressed, DBA disappeared in serous cells and only the DBA remained in mucous cells. These results suggest that Galβ (1,3) > Galβ(1,4) > Gal, αGalNAc > αGal > βGalNAc, NeuAc > (GalNAc)2-3>>>GlcNAc, and GalNAcα(1,3) are present in the early stage of development, but that GalNAcα(1,3) disappear in serous cells and only GalNAcα(1,3) are localized in mucous cells after maturation. These results indicate that Weber glands function as serous glands in the early postnatal stage when von Ebner glands have not matured.