目的:糖尿病会增加痴呆的风险,死亡率,老年人的认知能力下降,可能是因为遗传变量,如APOE。在这项研究中,我们的目的是评估APOEº4携带者的糖尿病和痴呆的风险。
方法:我们彻底搜索了PubMed(Medline),Scopus,以及截至2023年9月的相关文章的谷歌学术数据库。标题,摘要,并对文章全文进行了综述;数据进行了提取和分析。
结果:该荟萃分析包括9个队列和7个横断面文章,共有42,390人。该研究发现,与非糖尿病携带者相比,患有2型糖尿病(T2D)的APOE4携带者患痴呆症的风险高48%(危害比;1.48,95CI1.36-1.60)。痴呆症的频率为10人中的3人(频率:0.3;95CI(0.15-0.48)。没有观察到显著的异质性。Egger\'stest,我们表演的,在纳入的文章中没有发现发表偏倚的迹象(p=0.2)。
结论:总体而言,糖尿病会增加患痴呆症的风险,但是仍然需要进一步的大规模研究来支持当前研究的结果。
OBJECTIVE: Diabetes raises the risk of dementia, mortality, and cognitive decline in the elderly, potentially because of hereditary variables such as APOE. In this study, we aim to evaluate Diabetes mellitus and the risk of incident dementia in APOE ɛ4 carriers.
METHODS: We thoroughly searched PubMed (Medline), Scopus, and Google Scholar databases for related articles up to September 2023. The titles, abstracts, and full texts of articles were reviewed; data were extracted and analyzed.
RESULTS: This meta-analysis included nine cohorts and seven cross-sectional articles with a total of 42,390 population. The study found that APOE ɛ4 carriers with type 2 diabetes (T2D) had a 48% higher risk of developing dementia compared to non-diabetic carriers (Hazard Ratio;1.48, 95%CI1.36-1.60). The frequency of dementia was 3 in 10 people (frequency: 0.3; 95%CI (0.15-0.48). No significant heterogeneity was observed. Egger\'s test, which we performed, revealed no indication of publication bias among the included articles (p = 0.2).
CONCLUSIONS: Overall, diabetes increases the risk of dementia, but further large-scale studies are still required to support the results of current research.