目的:我们旨在研究Omicron变异感染对择期手术患者围手术期器官功能的影响。方法:选择2022年10月至2023年1月在我院行择期手术的5029例患者。其中,在2022年10月至2022年11月期间接受择期手术的患者将第1组(未感染Omicron变异体)视为对照组;在2022年12月至2023年1月期间接受择期手术的患者将第2组(Omicron变异体感染后1个月)视为实验组.我们进一步将患者分为两个亚组进行分析:肿瘤亚组和非肿瘤亚组。器官系统功能指标数据,包括凝血参数,肝功能,全血细胞计数(CBC),和肾功能,在手术前后收集。随后通过二元逻辑回归分析两组之间的差异。结果:与未感染患者组相比,在感染后一个月接受择期手术的Omicron变异型感染患者中观察到以下变化:凝血酶原活动度(PTa),凝血酶原时间(PT),纤维蛋白原,白蛋白/球蛋白,丙氨酸氨基转移酶(ALT),平均红细胞血红蛋白浓度(MCHC),血小板(PLT),和贫血增加AST/ALT,间接胆红素(IBILI),嗜酸性粒细胞,术前尿酸下降;肺部感染/肺炎和纤维蛋白原升高,而AST/ALT,球蛋白,总胆红素(TBIL),白细胞计数(WBC),术后尿酸下降。两组的死亡率和住院时间(LOS)没有显着差异。亚组分析显示单核细胞升高,PLT,和纤维蛋白原分类,水平和减少的球蛋白,前白蛋白(PBA),嗜酸性粒细胞,与未感染患者相比,在Omicron感染后一个月接受择期手术的患者的肿瘤亚组中的尿酸水平。与非肿瘤亚组相比,纤维蛋白原水平,肺部感染/肺炎,TBIL,未感染患者的PLT计数增加,而球蛋白和嗜酸性粒细胞水平下降。结论:与未感染患者相比,Omicron变异型感染后1个月接受择期手术的患者围手术期凝血参数变化最小,肝功能,CBC计数,和肾功能。此外,两组在术后死亡率或LOS方面无显著差异.
Purpose: We aimed to investigate the impact of Omicron variant infection on the perioperative organ function in patients undergoing elective surgery. Methods: A total of 5029 patients who underwent elective surgery between October 2022 and January 2023 at our hospital were enrolled. Among them, the patients who underwent elective surgery between October 2022 and November 2022 composed Group 1 (not infected with the Omicron variant) the control group; those who underwent elective surgery between December 2022 and January 2023 composed Group 2 (one month after Omicron variant infection) the experimental group. We further divided the patients into two subgroups for analysis: the tumor subgroup and the nontumor subgroup. Data on organ system function indicators, including coagulation parameters, liver function, complete blood count (CBC), and kidney function, were collected before and after surgery. Differences between the two groups were subsequently analyzed via binary logistic regression analysis. Results: Compared with those in the uninfected patient group, the following changes were observed in patients with Omicron variant infection who underwent elective surgery one month after infection: prothrombin activity (PTa), prothrombin time (PT), fibrinogen, albumin/globulin, alanine aminotransferase (ALT), mean corpuscular hemoglobin concentration (MCHC), platelet (PLT), and anemia were increased AST/ALT, indirect bilirubin (IBILI), eosinophils, and uric acid were decreased before surgery; and lung infection/pneumonia and fibrinogen were increased, while AST/ALT, globulin, total bilirubin (TBIL), white blood cell count (WBC), and uric acid were decreased after surgery. There was no significant difference in the mortality rate or length of hospital stay (LOS) between the two groups. Subgroup analysis revealed elevated monocyte, PLT, and fibrinogen classification, levels and decreased globulin, prealbumin (PBA), eosinophil, and uric acid levels in the tumor subgroup of patients who underwent elective surgery one month after Omicron infection compared with those in the uninfected patients. Compared with the nontumor subgroup, fibrinogen levels, lung infection/pneumonia, TBIL, and PLT count were increased in the uninfected patients, while the globulin and eosinophil levels were decreased. Conclusion: Compared with uninfected patients, patients who underwent elective surgery one month after Omicron variant infection exhibited minimal changes in perioperative coagulation parameters, liver function, CBC counts, and kidney function. Additionally, no significant differences in postoperative mortality or LOS were observed between the two groups.