Federal Government

联邦政府
  • 文章类型: Journal Article
    产前护理的保险范围,分娩和分娩护理,无证移民的产后护理由州和联邦政策拼凑而成,各州差异很大。根据联邦法律,各州必须通过紧急医疗补助为劳动力和分娩提供保险。各州通过政策机制,如儿童健康保险计划的“未出生儿童”选项,为无证移民提供额外的产前和产后保险,扩大医疗补助,和独立的国家级机制。通过搜索州医疗补助和联邦政府网站,我们发现27个州和哥伦比亚特区提供额外的产前护理保险,产后护理,或者两者兼而有之,23个国家没有。12个州包括任何产后保险;7提供产后12个月的保险。尽管有关覆盖范围的信息可以在网上公开获得,有许多障碍,例如缺乏透明度,缺乏多种语言的信息,和不正确的信息。需要采取更具包容性和更容易获得的政策,作为改善无证移民孕产妇健康的第一步,陷入复杂的移民政策和孕产妇健康危机的人口。(AmJ公共卫生。在2024年8月15日印刷之前在线发布:e1-e10。https://doi.org/10.2105/AJPH.2024.307750).
    Insurance coverage for prenatal care, labor and delivery care, and postpartum care for undocumented immigrants consists of a patchwork of state and federal policies, which varies widely by state. According to federal law, states must provide coverage for labor and delivery through Emergency Medicaid. Various states have additional prenatal and postpartum coverage for undocumented immigrants through policy mechanisms such as the Children\'s Health Insurance Program\'s \"unborn child\" option, expansion of Medicaid, and independent state-level mechanisms. Using a search of state Medicaid and federal government websites, we found that 27 states and the District of Columbia provide additional coverage for prenatal care, postpartum care, or both, while 23 states do not. Twelve states include any postpartum coverage; 7 provide coverage for 12 months postpartum. Although information regarding coverage is available publicly online, there exist many barriers to access, such as lack of transparency, lack of availability of information in multiple languages, and incorrect information. More inclusive and easily accessible policies are needed as the first step toward improving maternal health among undocumented immigrants, a population trapped in a complicated web of immigration policy and a maternal health crisis. (Am J Public Health. 2024;114(10):1051-1060. https://doi.org/10.2105/AJPH.2024.307750).
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  • 文章类型: Journal Article
    背景:可持续发展目标(SDG)的相互依存和交叉性质需要政府部门之间的合作。过去很少互动的部门很可能会发现自己参与了可持续发展目标项目的联合任务。部门间行动(IA)正在成为不同部门共同努力的共同框架。了解制定IA的政策团队外部的环境因素对于在可持续发展目标方面取得进展至关重要。
    方法:对加拿大联邦政府9个部门领导可持续发展目标工作的高级公务员进行了访谈[n=17],以获取有关影响部门如何参与可持续发展目标IA的问题的信息。成绩单是根据与加拿大在可持续发展目标方面的进展有关的20份文件的背景审查中确定的一组因素进行编码的。作者的迭代小组主题分析阐明了影响可持续发展目标IA流程的一系列国内和全球背景因素。
    结果:成功的IA机制被确定为促进治理,由中央协调办公室领导,支持人员,灵活清晰的报告结构,充足的资源,和有针对性的技能发展侧重于协作和跨部门学习。积极影响IA的因素包括可持续发展目标议程与国内和全球政治优先事项的一致性。土著权利和性别平等等社会问题的共同出现,这些问题提高了对相关可持续发展目标的认识和支持。对IA产生负面影响的因素包括竞争概念框架,以接近共同的优先事项,官僚员工缺乏“大局”思维的能力,和全球破坏使国家优先事项从可持续发展目标转移。
    结论:IA正在成为解决与政府问责制不同的问题的正常方法。这些合作的成功可能受到任何一个部门无法控制的背景因素的影响。
    BACKGROUND: The interdependent and intersecting nature of the Sustainable Development Goals (SDGs) require collaboration across government sectors, and it is likely that departments with few past interactions will find themselves engaged in joint missions on SDG projects. Intersectoral action (IA) is becoming a common framework for different sectors to work together. Understanding the factors in the environment external to policy teams enacting IA is crucial for making progress on the SDGs.
    METHODS: Interviews [n=17] with senior public servants leading SDG work in nine departments in the federal government of Canada were conducted to elicit information about issues affecting how departments engage in IA for the SDGs. Transcripts were coded based on a set of factors identified in a background review of 20 documents related to Canada\'s progress on SDGs. Iterative group thematic analysis by the authors illuminated a set of domestic and global contextual factors affecting IA processes for the SDGs.
    RESULTS: The mechanisms for successful IA were identified as facilitative governance, leadership by a central coordinating office, supportive staff, flexible and clear reporting structures, adequate resources, and targeted skills development focused on collaboration and cross-sector learning. Factors that affect IA positively include alignment of the SDG agenda with domestic and global political priorities, and the co-occurrence of social issues such as Indigenous rights and gender equity that raise awareness of and support for related SDGs. Factors that affect IA negatively include competing conceptual frameworks for approaching shared priorities, lack of capacity for \"big picture\" thinking among bureaucratic staff, and global disruptions that shift national priorities away from the SDGs.
    CONCLUSIONS: IA is becoming a normal way of working on problems that cross otherwise separate government accountabilities. The success of these collaborations can be impacted by contextual factors beyond any one department\'s control.
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  • 文章类型: Journal Article
    背景:2019年冠状病毒病(COVID-19)大流行迫切需要进行临床试验,以发现安全有效的治疗方法。我们检查了COVID-19的经历,临床试验意识,对疫苗安全过程的信任与参与COVID-19临床试验的意愿相关。目的是调查在COVID-19大流行期间的18个月内,在四个不同的时间点,对联邦疫苗安全性监督的信任与参与COVID-19治疗临床试验的意愿之间的关系。
    方法:我们使用了从2021年9月至2023年3月在582名费城居民中收集的四波数据(数据缺失率为0.9%)。广义估计方程估计了参与COVID-19临床试验的意愿与参与者对联邦政府监督COVID-19疫苗安全性的信任之间的关联,COVID-19相关变量(COVID-19相关健康挑战,COVID-19感染史),了解临床试验以及如何注册,和社会人口统计学特征(年龄,种族/民族,性取向,性别,父母身份,教育,和保险)。
    结果:平均而言,参加COVID-19临床试验的意愿与联邦政府对疫苗安全性监督的更大信任呈正相关[β=0.34,95%置信区间(CI):0.15-0.53],患有COVID-19(β=0.40,95%CI:0.08-0.73),对临床试验的认识(β=0.38,95%CI:0.04-0.73),以及如何注册的知识(β=0.83,95%CI:0.44-1.23)。在社会人口统计学特征中,种族/民族(p=0.001)和性别(p=0.018)被确定为COVID-19试验意愿的预测因子。
    结论:通过加强公众对联邦政府在疫苗安全监督中的作用的信任,可以增强参与临床试验的意愿,增加临床试验与个人健康和福祉的感知相关性,并提供量身定制的信息,以教育不同的社区关于正在进行的试验以及如何注册。
    BACKGROUND: The Coronavirus Disease 2019 (COVID-19) pandemic precipitated an urgent need for clinical trials to discover safe and efficacious treatments. We examined how COVID-19 experiences, clinical trial awareness, and trust in the vaccine safety process were associated with willingness to participate in COVID-19 clinical trials. The objective was to investigate the relationship between trust in federal oversight of vaccine safety and willingness to participate in clinical trials for COVID-19 treatment across four distinct time points over an 18-month period during the COVID-19 pandemic.
    METHODS: We used four waves of data collected from September 2021 to March 2023 among 582 Philadelphia residents (with a missing data rate of 0.9%). Generalized estimating equations estimated the association between willingness to participate in COVID-19 clinical trials and participants\' trust in the federal government\'s oversight of COVID-19 vaccine safety, COVID-19-related variables (COVID-19 related health challenges, history of COVID-19 infection), awareness of clinical trials and how to enroll in them, and sociodemographic characteristics (age, race/ethnicity, sexual orientation, gender, parental status, education, and insurance).
    RESULTS: On average, willingness to participate in a COVID-19 clinical trial was positively associated with greater trust in the federal government\'s oversight of vaccine safety [β = 0.34, 95% confidence interval (CI): 0.15-0.53], having COVID-19 (β = 0.40, 95% CI: 0.08-0.73), awareness of clinical trials (β = 0.38, 95% CI: 0.04-0.73), and knowledge of how to enroll (β = 0.83, 95% CI: 0.44-1.23). Among sociodemographic characteristics, race/ethnicity (p = 0.001) and gender (p = 0.018) were identified as predictors for COVID-19 trial willingness.
    CONCLUSIONS: Willingness to participate in clinical trials may be bolstered by strengthening the public\'s trust in the federal government\'s role within vaccine safety oversight, increasing the perceived relevance of clinical trials to individuals\' health and well-being, and offering tailored information to educate diverse communities about ongoing trials and how to enroll in them.
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  • 文章类型: Journal Article
    波多黎各,自1898年以来,美国的一个领土,最近经历了越来越频繁和强度的自然灾害和突发公共卫生事件。2022年,飓风菲奥娜成为最新的风暴,吸引了媒体的关注,并揭示了波多黎各不断恶化的状况。包括基础设施故障,医疗保健提供者短缺,和高水平的慢性病。尽管最近的事件具有独特的破坏性,几十年来不公平的美国联邦政策做法助长了该地区健康不平等的持续存在。在这里,我们展示了波多黎各现有的健康和医疗保健不平等如何因加剧灾难而加剧,但植根于美国联邦政策对领土的区别对待。具体来说,我们关注美国联邦紧急事务管理局对该地区灾难的不平等反应,波多黎各联邦医疗补助资金缺乏平等,和波多黎各作为美国领土的有限政治权力。我们还提供了经验支持的政策建议,旨在减少经常被遗忘的波多黎各美国领土上的健康和医疗保健不平等。(AmJ公共卫生。2024;114(S6):S478-S484。https://doi.org/10.2105/AJPH.2024.307585)[公式:见正文]。
    Puerto Rico, a territory of the United States since 1898, has recently experienced an increasing frequency and intensity of natural disasters and public health emergencies. In 2022, Hurricane Fiona became the latest storm to attract media attention and cast a light on Puerto Rico\'s deteriorating conditions, including infrastructural failings, health care provider shortages, and high levels of chronic illness. Although recent events have been uniquely devastating, decades of inequitable US federal policy practices have fueled the persistence of health inequities in the territory. Here we demonstrate how existing health and health care inequities in Puerto Rico have been exacerbated by compounding disasters but are rooted in the differential treatment of the territory under US federal policies. Specifically, we focus on the unequal US Federal Emergency Management Agency response to disasters in the territory, the lack of parity in federal Medicaid funding for Puerto Rico, and Puerto Rico\'s limited political power as a territory of the United States. We also provide empirically supported policy recommendations aimed at reducing health and health care inequities in the often-forgotten US territory of Puerto Rico. (Am J Public Health. 2024;114(S6):S478-S484. https://doi.org/10.2105/AJPH.2024.307585) [Formula: see text].
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  • 文章类型: Journal Article
    与部落主权相一致的跨辖区合作努力和紧急疫苗计划对于公共卫生应急准备至关重要。广泛采用书面清晰的联邦,state,以及解决向部落国家分发疫苗的基本假设的当地疫苗计划对于未来的大流行反应至关重要。
    Cross jurisdictional collaboration efforts and emergency vaccine plans that are consistent with Tribal sovereignty are essential to public health emergency preparedness. The widespread adoption of clearly written federal, state, and local vaccine plans that address fundamental assumptions in vaccine distribution to Tribal nations is imperative for future pandemic response.
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  • 文章类型: Journal Article
    在第一批COVID-19疫苗于2020年12月获得美国FDA的紧急使用授权后,美国各州采用了疫苗资格和管理计划(VEAP),该计划确定了居民亚组何时有资格接受疫苗,而疫苗供应仍然有限。在这些计划的实施过程中,公众越来越关注来自联邦政府的VEAP和疫苗分配是否会导致疫苗分配公平和有效.在这项研究中,我们收集了五个州的数据,联邦疫苗分配,疫苗管理,和疫苗犹豫,以评估在运动期间表现出的疫苗获取和疫苗管理效率的公平性。我们的结果表明,与其他州相比,较早开放疫苗资格的州的居民在接受疫苗方面的竞争更多。无论处于哪个状态,在所有5个州中,疫苗管理一直存在低效率,这可归因于州和联邦基础设施的赤字.仔细检查发现,在整个竞选活动中,联邦疫苗分配与各州的合格总人口之间存在偏差,即使考虑到犹豫。我们得出的结论是,为了最大限度地提高未来大规模疫苗接种运动的效率,联邦和州政府应设计适应性强的分配政策和资格计划,以更好地匹配真实,通过考虑疫苗的犹豫和制造能力,实时提供疫苗的供应和需求。Further,我们讨论实施这些战略的挑战。
    After the first COVID-19 vaccines received emergency use authorization from the U.S. FDA in December 2020, U.S. states employed vaccine eligibility and administration plans (VEAPs) that determined when subgroups of residents would become eligible to receive the vaccine while the vaccine supply was still limited. During the implementation of these plans, public concern grew over whether the VEAPs and vaccine allocations from the federal government were resulting in an equitable and efficient vaccine distribution. In this study, we collected data on five states\' VEAPs, federal vaccine allocations, vaccine administration, and vaccine hesitancy to assess the equity of vaccine access and vaccine administration efficiency that manifested during the campaign. Our results suggest that residents in states which opened eligibility to the vaccine sooner had more competition among residents to receive the vaccine than occurred in other states. Regardless of states\' VEAPs, there was a consistent inefficiency in vaccine administration among all five states that could be attributed to both state and federal infrastructure deficits. A closer examination revealed a misalignment between federal vaccine allocations and the total eligible population in the states throughout the campaign, even when accounting for hesitancy. We conclude that in order to maximize the efficiency of future mass-vaccination campaigns, the federal and state governments should design adaptable allocation policies and eligibility plans that better match the true, real-time supply and demand for vaccines by accounting for vaccine hesitancy and manufacturing capacity. Further, we discuss the challenges of implementing such strategies.
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  • 文章类型: Journal Article
    OBJECTIVE: To systematically assess the Canadian federal government\'s current alcohol policies in relation to public health best practices.
    METHODS: The 2022 Canadian Alcohol Policy Evaluation (CAPE) Project assessed federal alcohol policies across 10 domains. Policy domains were weighted according to evidence for their relative impact, including effectiveness and scope. A detailed scoring rubric of best practices was developed and externally reviewed by international experts. Policy data were collected between June and December 2022, using official legislation, government websites, and data sources identified from previous iterations of CAPE as sources. Contacts within relevant government departments provided any additional data sources, reviewed the accuracy and completeness of the data, and provided amendments as needed. Data were scored independently by members of the research team. Final policy scores were tabulated and presented as a weighted overall average score and as unweighted domain-specific scores.
    RESULTS: Compared to public health best practices, the federal government of Canada scored 37% overall. The three most impactful domains-(1) pricing and taxation, (2) marketing and advertising controls, and (3) impaired driving countermeasures-received some of the lowest scores (39%, 10%, and 40%, respectively). Domain-specific scores varied considerably from 0% for minimum legal age policies to 100% for controls on physical availability of alcohol.
    CONCLUSIONS: Many evidence-informed alcohol policies have not been adopted, or been adopted only partially, by the Canadian federal government. Urgent adoption of the recommended policies is needed to prevent and reduce the enormous health, social, and economic costs of alcohol use in Canada.
    RéSUMé: OBJECTIF: Évaluer de manière systématique les politiques sur l’alcool actuelles du gouvernement fédéral canadien dans le cadre de pratiques de santé publique exemplaires. MéTHODES: Le projet de l’Évaluation des politiques canadiennes sur l’alcool 2022 a évalué les politiques fédérales sur l’alcool dans dix domaines. Ces domaines de politiques ont été pondérés en fonction de preuves sur leurs répercussions relatives, notamment leur efficacité et leur portée. Une échelle d’évaluation descriptive détaillée de pratiques exemplaires a été élaborée et examinée à l’externe. Entre juin et décembre 2022, des données sur les politiques ont été recueillies dans la législation officielle, sur des sites Web du gouvernement et au moyen de sources identifiées comme telles au cours des itérations précédentes du projet de l’Évaluation des politiques canadiennes sur l’alcool. Des personnes-ressources au sein des ministères concernés ont communiqué d’autres sources de données, examiné l’exactitude et le caractère exhaustif de ces données et apporté les modifications nécessaires. Les données ont été évaluées indépendamment par des membres de l’équipe de recherche. Les scores de politiques finaux ont été inscrits dans des tableaux et présentés sous forme d’une moyenne générale pondérée et de scores non pondérés par domaine. RéSULTATS: Comparativement aux pratiques de santé publique exemplaire, le gouvernement fédéral du Canada a obtenu un score général de 37 %. Les trois domaines susceptibles d’avoir les plus grandes répercussions, à savoir 1) la fixation des prix et la taxation, 2) le contrôle du marketing et de la publicité, et 3) les mesures contre la conduite avec facultés affaiblies, se sont vu attribuer parmi les scores les plus bas (39 %, 10 %, et 40 % respectivement). Les scores par domaine variaient considérablement, allant de 0 % pour les politiques sur l’âge minimum légal à 100 % pour le contrôle de la disponibilité physique de l’alcool. CONCLUSION: De nombreuses politiques sur l’alcool reposant sur des preuves n’ont pas été adoptées, ou l’ont été seulement partiellement, par le gouvernement fédéral canadien. Il est urgent d’appliquer les politiques recommandées pour prévenir et réduire les énormes coûts sanitaires, sociaux et économiques de la consommation d’alcool au Canada.
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  • 文章类型: English Abstract
    Argentina, as other countries, showed several public policies related to the health technologies implemented to fight and treat the COVID-19 pandemic. This study sought to analyze how articulation vs. cooperation and autonomy vs. division of powers between entities occurred in Argentina, exploring asymmetries between several entities in implementing public policies related to health technologies during the pandemic and the influences of other actors. For this, a documentary research was carried out related to 2020-2021 (technical reports published by the World Health Organization, national agencies and scientific societies, laws, court decisions, press, and research and in-depth interviews with members of the Argentine Ministries of Health). The processes and results of decision-making in the Ministries of Health were analyzed, outlining the coverage and orientations of each technology and the political party in power in the province. This study found heterogeneous results and processes between Ministries and disputes within them. It also observed the poor adherence to official guidelines due to technical-political criteria (power relations, social, media, academic, judiciary, and legislative pressure). Some cases showed a strong tension between the government and its opposition over the discussion of technologies. Each province in Argentina has autonomously defined its policies on health technologies for COVID-19, and decision-making in public administration was disorderly, complex, and non-linear during the pandemic.
    En pandemia, en Argentina y en otros países se observó variabilidad en las políticas públicas implementadas sobre tecnologías sanitarias para prevención y tratamiento de la COVID-19. El objetivo fue analizar cómo se procesaron en Argentina los movimientos de coordinación vs. cooperación, y de autonomía vs. reparto de autoridad entre entidades, explorando asimetrías entre diferentes entidades en la implementación de políticas públicas sobre tecnologías sanitarias en pandemia y las influencias de otros actores. Se realizó una revisión documental del período 2020-2021 (informes técnicos publicados por la Organización Mundial de la Salud, organismos nacionales y sociedades científicas, leyes, fallos judiciales, prensa, encuestas y entrevistas en profundidad a miembros de los Ministerios de Salud de Argentina). Se indagó sobre procesos y resultados de la toma de decisiones en los Ministerios de Salud, mapeando la cobertura y recomendación de cada tecnología y el partido político provincial gobernante. Hubo heterogeneidad en resultados y procesos entre los Ministerios, y disputas en el interior de los mismos. La adherencia a recomendaciones oficiales fue baja, influyendo distintos criterios técnico-políticos (relaciones de poder, presión social, de los medios, académicos, poder Judicial y Legislativo). En algunos casos se observó una fuerte tensión entre oficialismo y oposición al partido gobernante a partir de la discusión sobre tecnologías. Cada provincia argentina definió sus políticas sobre tecnologías sanitarias para COVID-19 con autonomía, y la toma de decisiones en la administración pública en pandemia fue desordenada, compleja y no lineal.
    Na Argentina, assim como em outros países, houve uma variabilidade de políticas públicas relacionadas às tecnologias de saúde implementadas no combate e tratamento da COVID-19 durante a pandemia. Este estudo buscou analisar como ocorreram a articulação vs. cooperação, e a autonomia vs. divisão de poderes entre as entidades na Argentina, explorando assimetrias entre diferentes entidades na implementação de políticas públicas relacionadas a tecnologias de saúde na pandemia, bem como as influências de outros atores. Para tanto, realizou-se uma pesquisa documental para o período de 2020-2021 (relatórios técnicos publicados pela Organização Mundial da Saúde, agências nacionais e sociedades científicas, leis, decisões judiciais, imprensa, pesquisas e entrevistas em profundidade com membros dos Ministérios da Saúde da Argentina). Os processos e os resultados da tomada de decisão nos Ministérios da Saúde foram analisados, traçando a cobertura e orientações de cada tecnologia e o partido político no poder na província. Observou-se uma heterogeneidade nos resultados e processos entre os Ministérios, e disputas em seu interior. Houve uma baixa adesão às orientações oficiais, influenciada por diferentes critérios técnico-políticos (relações de poder, pressão social, midiática, acadêmica, do poder Judiciário e do Legislativo). Em alguns casos, observou-se uma forte tensão entre governo e oposição a partir da discussão das tecnologias. Cada província da Argentina definiu suas políticas sobre tecnologias de saúde para a COVID-19 de forma autônoma, e a tomada de decisões na administração pública foi desordenada, complexa e não linear durante a pandemia.
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  • 文章类型: Journal Article
    目的是分析巴西联邦法官对COVID-19疫苗接种影响的看法。对巴西联邦法官进行了一项研究,他接受了一项关于COVID-19疫苗接种的多项选择题的调查,涵盖其强制性方面等主题,采取强制措施,犹豫接种疫苗,优先群体,巴西卫生监管机构的职责(Anvisa,葡萄牙语的首字母缩写),司法部门的角色,豁免护照。来自各州的1300名联邦法官中,共有254名对调查做出了回应。大多数受访者拥有学士学位或专业学位(59.1%),并且担任法官超过10年(63.8%)。绝大多数法官(87.7%)同意成人以及儿童和青少年的疫苗授权(66.1%)。超过75%的法官认为,各级政府可以对拒绝接种疫苗的人实施制裁。法官们93%的时间信任疫苗接种,56.1%的人拒绝反疫苗接种运动,75.2%的人认为应尊重Anvisa的职责。62.6%的法官批准了司法部门关于COVID-19大流行的行动,88.2%的人支持豁免护照。强制接种疫苗之间有直接联系,对疫苗的信任,以及采用豁免护照。大多数联邦法官都同意针对儿童和成人的疫苗授权,支持对拒绝接种疫苗的制裁,不赞成反疫苗接种运动,同意安维萨的职责,并支持对COVID-19大流行的司法干预。
    The aim was to analyze the perception of Brazilian federal judges on the implications of COVID-19 vaccination. A study was carried out with Brazilian federal judges, who received a survey designed with multiple-choice questions on COVID-19 vaccination, covering topics such as its mandatory aspect, the application of coercive measures, hesitation to vaccinate, priority groups, the duties of Brazilian Health Regulatory Agency (Anvisa, acronym in Portuguese), the role of the Judiciary branch, and immunity passports. A total of 254 out of 1,300 federal judges from all states responded to the survey. Most respondents have a Bachelor\'s degree or a specialization (59.1%) and have been judges for more than 10 years (63.8%). A great majority of the judges (87.7%) agree with vaccine mandates for adults and for children and adolescents (66.1%). Over 75% of judges believe that all levels of government can impose sanctions on those who refuse to get vaccinated. The judges trust vaccination 93% of the time, 56.1% reject anti-vaccination movements, and 75.2% believe that Anvisa duties should be respected. The Judiciary branch actions concerning the COVID-19 pandemic are approved by 62.6% of judges, and 88.2% support immunity passports. There is a direct connection among mandatory vaccination, trust in the vaccine, and the adoption of immunity passports. Most federal judges agree with vaccine mandates for children and adults, support the application of sanctions for vaccination refusal, disapprove of anti-vaccination movements, agree with Anvisa\'s duties, and support judicial intervention in relation to the COVID-19 pandemic.
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  • 文章类型: Journal Article
    监测和识别新兴的,重新出现,和未知的传染病病原体对于国家公共卫生准备至关重要,并且依赖于流动性,协调,公共和私人病原体监测系统和网络之间的相互联系。利用现有资源和基础设施发展国家哨点监控网络可以提高效率,加快识别新出现的公共卫生威胁,并支持降低发病率和死亡率的协调干预策略。然而,实施和维持计划,以使用先进的分子方法检测人类中新兴和重新出现的病原体,例如宏基因组测序,需要在测试设备和发展临床医生网络方面进行大量投资,实验室科学家,和生物信息学家。在这项研究中,我们试图了解联邦政府机构目前如何支持在美国对人体标本进行病原体不可知检测.我们对联邦机构网站进行了景观分析,以获取有关病原体不可知测试的可用性和类型以及临床标本和数据流的详细信息的公开信息。对网站分析进行了补充,并与联邦机构的代表对结果进行了专家审查。美国卫生与人类服务部和美国退伍军人事务部的运营部门已经开发并维持了广泛的临床和研究网络,以获取患者标本并进行宏基因组测序。由美国机构支持的宏基因组设施在美国各地的地理分布不均。尽管许多实体致力于宏基因组学和/或支持新出现的传染病监测标本收集,机构间的正式合作很少。
    The surveillance and identification of emerging, reemerging, and unknown infectious disease pathogens is essential to national public health preparedness and relies on fluidity, coordination, and interconnectivity between public and private pathogen surveillance systems and networks. Developing a national sentinel surveillance network with existing resources and infrastructure could increase efficiency, accelerate the identification of emerging public health threats, and support coordinated intervention strategies that reduce morbidity and mortality. However, implementing and sustaining programs to detect emerging and reemerging pathogens in humans using advanced molecular methods, such as metagenomic sequencing, requires making large investments in testing equipment and developing networks of clinicians, laboratory scientists, and bioinformaticians. In this study, we sought to gain an understanding of how federal government agencies currently support such pathogen agnostic testing of human specimens in the United States. We conducted a landscape analysis of federal agency websites for publicly accessible information on the availability and type of pathogen agnostic testing and details on flow of clinical specimens and data. The website analysis was supplemented by an expert review of results with representatives from the federal agencies. Operating divisions within the US Department of Health and Human Services and the US Department of Veterans Affairs have developed and sustained extensive clinical and research networks to obtain patient specimens and perform metagenomic sequencing. Metagenomic facilities supported by US agencies were not equally geographically distributed across the United States. Although many entities have work dedicated to metagenomics and/or support emerging infectious disease surveillance specimen collection, there was minimal formal collaboration across agencies.
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