目的:评估输血传播感染(TTI)与ABO之间的关系,Rh-D,献血者中的凯尔血液系统。
方法:这是一项对10,095名捐献者的回顾性研究,这些捐献者访问了Asir医院的血库,Abha,沙特阿拉伯。数据包括人口统计信息,ABO,Rh-D,和凯尔血型,以及TTIs的血清学和分子检测结果(TTIs从每个供体的记录中获得)。采用卡方检验和Fisher精确检验来确定血型和TTI之间可能的关联。
结果:供者中的TTI患病率为6.3%,HBcAb(70%)是阳性供体中最普遍的生物标志物。O型血的捐献者感染TTI的风险较高。在HIV和A血型之间观察到显著关联(χ2=6.30,p=0.01),HBsAg和AB组(χ2=17.3193,p=0.00003),疟疾和A组(χ2=5.0567,p=0.02),HBV-DNA和AB组(χ2=12.3163,p=0.0004)。此外,Kell血型与HIV显著相关(χ2=14.5,p=0.0001),HBcAb(χ2=78.51,p<0.0001),梅毒(χ2=25.225,p<0.00001)。
结论:ABO和Kell血型与TTI标志物相关。这些发现强调了在筛查和管理献血方面需要改进的策略和方法,以最大程度地降低TTI的风险。
OBJECTIVE: To evaluate the association between transfusion-transmitted infections (TTIs) and ABO, Rh-D, and Kell blood systems among blood
donors.
METHODS: This was a retrospective study of 10,095
donors who visited the Blood Bank at Asir Hospital, Abha, Saudi Arabia. Data including demographic information, ABO, Rh-D, and Kell blood groups, and serological and molecular test results of TTIs (the TTIs were obtained from each donor\'s records). Chi-squared and Fisher\'s exact tests were employed to establish possible associations between blood groups and TTIs.
RESULTS: The prevalence rate of TTIs among
donors was 6.3%, with HBcAb (70%) being the most prevalent biomarker among positive
donors.
Donors with the O blood group were at a higher risk of contracting TTIs. Significant associations were observed between HIV and blood group A (χ2=6.30, p=0.01), HBsAg and group AB (χ2=17.3193, p=0.00003), malaria and group A (χ2=5.0567, p=0.02), and HBV-DNA and group AB (χ2=12.3163, p=0.0004). Also, Kell blood group was significantly associated with HIV (χ2=14.5, p=0.0001), HBcAb (χ2=78.51, p<0.0001), and syphilis (χ2=25.225, p<0.00001).
CONCLUSIONS: ABO and Kell blood groups are associated with TTI markers. These findings highlight the need for improved strategies and approaches in screening and managing blood donations to minimize the risk of TTIs.