血管勃起功能障碍(ED)的诊断测试取决于体内注射(ICI)后海绵状平滑肌(CSM)松弛。增强的交感神经张力,这在这些测试的执行过程中并不罕见,可能会偏向其结果。此外,CSM疾病可引起静脉闭塞性疾病(VOD)ED。阴茎海绵体肌电图(CC-EMG)电位\'振幅代表健康CSM的整合交感神经活动。干细胞和基因治疗是受损CSM的潜在治疗选择。
为了利用CC-EMG,作为一种新的诊断技术,可以确认CSM的完整性,并识别CSM活动受损的患者,在根据彩色多普勒超声(CDDU)诊断为血管ED的患者中。
第1组包括24例ED和ICI阴性反应的患者。第2组包括10名没有ED的男性。第1组患者接受了阴茎CDDU检查,所有参与者都有自发的CC-EMG记录。
根据CDDU参数,第1组分为9条动脉,十个VOD和五个混合型。第2组和动脉的CC-EMG电位振幅范围为223-320、179-237、103-250和83-200μV,分别为混合和VOD亚组。在具有VOD元素的患者亚组中记录了最大范围的电位\'振幅。四名ED患者,在这些子群体中,CC-EMG电位\'振幅范围为200-250μV,超过/接近第2组男性记录的最低值。
CC-EMG记录在诊断为每个CDDU的VODED元素的患者中引起CSM活性的显着差异。这一发现强调了利用CC-EMG评估CSM完整性的必要性。识别CSM活动受损的患者可以修改所选择的治疗干预方法。
Diagnostic tests for vascular erectile dysfunction (ED) depend on cavernous smooth muscles (CSM) relaxation following an intracorporal injection (ICI). Enhanced sympathetic tone, which is not uncommon during performance of these tests, can bias its results. Also, CSM diseases can cause veno-occlusive diseases (VOD) ED. Corpus cavernosum electromyography (CC-EMG) potentials\' amplitudes represent the integrated sympathetic activity of healthy CSM. Stem-cells and gene-therapy are potential therapeutic options for impaired CSM.
To utilize CC-EMG, as a new diagnostic technique that can confirm the integrity of CSM, and to identify patients with impaired CSM activity, among those diagnosed as vascular ED per Color Duplex Doppler Ultrasonography (CDDU).
Group 1 included 24 patients with ED and negative response to ICI. Group 2 included 10 men without ED. Patients included in group 1 had penile CDDU examination and all participants had spontaneous CC-EMG recordings.
According to CDDU parameters, group 1 was sub-grouped as nine arterial, ten VOD and five mixed type. CC-EMG potentials\' amplitudes ranged 223-320, 179-237, 103-250 and 83-200μV for group 2 and arterial, mixed and VOD subgroups respectively. The widest ranges of potentials\' amplitudes were recorded in the subgroups of patients with an element of VOD. Four patients with ED, within these subgroups, had CC-EMG potentials\' amplitudes ranged 200-250μV that exceeded/approached the lowest value recorded from men in group 2.
CC-EMG recordings elicited marked differences of CSM activity among patients diagnosed with an element of VOD ED per CDDU. This finding highlighted the need to utilize CC-EMG to assess the integrity of CSM. Identifying patients with impaired CSM activity may modify the chosen methods for therapeutic interventions.