PDF(Pubmed)
Abstract：
Studies have reported that coronavirus disease 2019 (COVID-19) may cause erectile dysfunction (ED), however, its role in the pathophysiology of ED has not yet been fully elucidated. We aimed to elucidate COVID-19\'s effects on cavernosal smooth muscle, which has a pretty important role in erection physiology, by corpus cavernosum electromyography (cc-EMG).
Twenty-nine male patients aged 20-50 years who applied to the urology outpatient clinic due to ED were included in the study. Nine patients that had COVID-19 and were treated as outpatients were classified as group 1, 10 patients who were hospitalized due to COVID-19 were classified as group 2, and 10 patients who did not have COVID-19 were classified as the control group (group 3). Patients underwent diagnostic evaluation including International Index of Erectile Function (IIEF)-5 form, penile color Doppler ultrasonography (CDUS), cc-EMG, and fasting serum levels of reproductive hormones (07-11am).
According to penile CDUS and hormonal values results, there was no significant difference between the groups. According to cc-EMG results, amplitudes and relaxation capacities of the cavernosal smooth muscle of patients in group 3 were significantly higher than those in the other groups.
COVID-19 can cause ED not only by psychogenic and hormonal factors but also with cavernosal smooth muscle damage.
NCT04980508.
Twenty-nine male patients aged 20-50 years who applied to the urology outpatient clinic due to ED were included in the study. Nine patients that had COVID-19 and were treated as outpatients were classified as group 1, 10 patients who were hospitalized due to COVID-19 were classified as group 2, and 10 patients who did not have COVID-19 were classified as the control group (group 3). Patients underwent diagnostic evaluation including International Index of Erectile Function (IIEF)-5 form, penile color Doppler ultrasonography (CDUS), cc-EMG, and fasting serum levels of reproductive hormones (07-11am).
According to penile CDUS and hormonal values results, there was no significant difference between the groups. According to cc-EMG results, amplitudes and relaxation capacities of the cavernosal smooth muscle of patients in group 3 were significantly higher than those in the other groups.
COVID-19 can cause ED not only by psychogenic and hormonal factors but also with cavernosal smooth muscle damage.
NCT04980508.
摘要：
背景：研究报告说2019年冠状病毒病（COVID-19）可能导致勃起功能障碍（ED），然而,其在ED病理生理学中的作用尚未完全阐明。我们旨在阐明COVID-19对海绵体平滑肌的影响，在勃起生理学中有着非常重要的作用，通过海绵体肌电图（cc-EMG）。
方法：29名年龄在20-50岁的男性患者因ED而申请泌尿外科门诊。9名患有COVID-19并作为门诊患者的患者被归类为第1组，10名因COVID-19住院的患者被归类为第2组，10名未患有COVID-19的患者被归类为对照组(第3组)。患者接受了包括国际勃起功能指数（IIEF）-5形式的诊断评估，阴茎彩色多普勒超声（CDUS），cc-EMG,和空腹血清生殖激素水平（07-11am）。
结果：根据阴茎CDUS和荷尔蒙值结果，组间无显著差异。根据cc-EMG结果，第3组患者海绵体平滑肌的振幅和松弛能力明显高于其他组。
结论：COVID-19不仅可以通过心理和激素因素引起ED，还可以引起海绵体平滑肌损伤。
背景：NCT04980508。
方法：29名年龄在20-50岁的男性患者因ED而申请泌尿外科门诊。9名患有COVID-19并作为门诊患者的患者被归类为第1组，10名因COVID-19住院的患者被归类为第2组，10名未患有COVID-19的患者被归类为对照组(第3组)。患者接受了包括国际勃起功能指数（IIEF）-5形式的诊断评估，阴茎彩色多普勒超声（CDUS），cc-EMG,和空腹血清生殖激素水平（07-11am）。
结果：根据阴茎CDUS和荷尔蒙值结果，组间无显著差异。根据cc-EMG结果，第3组患者海绵体平滑肌的振幅和松弛能力明显高于其他组。
结论：COVID-19不仅可以通过心理和激素因素引起ED，还可以引起海绵体平滑肌损伤。
背景：NCT04980508。
