该研究旨在调查美沙酮维持治疗(MMT)的依从性,并确定在台湾注射诊断为人类免疫缺陷病毒(HIV)感染的药物的患者的相关临床因素。
数据来自国家艾滋病毒健康监测系统和MMT国家药物治疗系统。将注射药物的HIV阳性者(HIVPWID)定义为研究人群。获得的信息包括年龄,性别,教育,婚姻状况,employment,美沙酮剂量,以及HIV感染的诊断日期。坚持被定义为在过去90、180和365天服用美沙酮,然后归类为高(>90%),中等(51%至90%),或低(<=50%)粘附。
从2007年到2012年,在数据集中注册的1641个HIVPWID中,有961个(58.56%)获得了MMT。对于90天评估的HIVPWID(n=951),271(28.5%),382(40.2%),298人(31.3%)被归类为高,中度,和低粘附性分别。对于180天评估的HIVPWID(n=936),190(20.3%),349(37.3%),397(42.4%)被归类为高,中度,和低粘附性分别。对于365天评估的HIVPWID(n=919),133(14.5%),271(29.5%),515人(56.0%)被归类为高,中度,和低粘附性分别。在控制了社会人口统计学之后,结果显示,美沙酮剂量,MMT诊所的位置,HIV诊断日期与MMT依从性显著相关.
研究结果强调了美沙酮剂量对MMT依从性的重要性,患者HIV感染的早期诊断,和患者居住地。
The study aims were to investigate adherence to methadone maintenance treatment (MMT) and to identify associated clinical factors in patients who inject drugs diagnosed with human immunodeficiency virus (HIV) infection in Taiwan.
Data were from the National Health Surveillance System on HIV and the National Drug Treatment System on MMT. HIV-positive people who inject drugs (HIVPWID) were defined as the study population. Information obtained included age, sex, education, marital status, employment, methadone dose, and date of diagnosis of HIV infection. Adherence was defined as taking methadone for the past 90, 180 and 365 days, then categorized as high (> 90%), moderate (51 to 90%), or low (<=50%) adherent respectively.
Of 1641 HIVPWID registered in the datasets from 2007 to 2012, 961 (58.56%) had received MMT. For HIVPWID evaluated at 90 days (n = 951), 271 (28.5%), 382 (40.2%), and 298 (31.3%) were classified as high, moderate, and low adherent respectively. For HIVPWID evaluated at 180 days (n = 936), 190 (20.3%), 349 (37.3%), and 397 (42.4%) were classified as high, moderate, and low adherent respectively. For HIVPWID evaluated at 365 days (n = 919), 133 (14.5%), 271 (29.5%), and 515 (56.0%) were classified as high, moderate, and low adherent respectively. After controlling for sociodemographics, results showed that methadone dose, location of MMT clinic, and date of HIV diagnosis were significantly associated with MMT adherence.
Study findings underscore the importance to MMT adherence of methadone dosage, early diagnosis of patient\'s HIV infection, and area of patient residence.