■2019冠状病毒病(COVID-19)疫苗是少数获得紧急授权以抗击致命大流行的疫苗之一。尽管一些现有文献讨论了它的短期副作用,其对1型糖尿病(T1DM)的影响仍然存在局限性。
■本研究的目的是评估T1DM患者中COVID-19疫苗接种与糖尿病酮症酸中毒(DKA)之间的关系。此外,这项研究旨在确定疫苗对血糖控制的影响,可变性,和低血糖的风险。
这项回顾性研究是在卡西姆地区的法哈德国王专科医院(KFSH)进行的,沙特阿拉伯。在2020年2月和2022年8月期间入院的糖尿病酮症酸中毒病例根据具体的纳入标准纳入研究。最后,共有49例患者被纳入统计分析.
■在住院的62名患者中,49符合DKA的诊断标准,并同意参与研究。其余大多数患者(n=13)拒绝参加,只有少数人缺乏完整的文档。在纳入研究的49名患者中,46例有T1DM病史;尽管如此,3例新诊断为T1DM。此外,在这些参与者中,16(32.7%),19(38.8%),14例(28.6%)患者有轻度,中度,和严重的DKA,分别。其中男性27例(55.1%),女性22例(44.9%)。约91%的患者接种了COVID-19疫苗,其中30.6%的患者在被诊断为DKA后29天内接种了疫苗。在接种疫苗29天内被诊断为DKA的患者中,观察到pH和碳酸氢盐水平明显较高,p值分别为0.031和0.037。同样,观察到接种疫苗的患者的pH和随机血糖(RBS)明显高于未接种疫苗的受试者(分别为P=0.044和P=0.032)。
研究结果表明,一些DKA指标在接种疫苗的患者中很明显。然而,我们建议进行更大规模和多中心的研究,以获得更确凿的证据并推广研究结果.
UNASSIGNED: The coronavirus disease 2019 (COVID-19) vaccine is one of the few vaccines that obtained emergency authorization to combat the fatal pandemic. Despite the fact that some available literature addressed its short-term side effects, there are still limitations on its effects on type 1 diabetes mellitus (T1DM).
UNASSIGNED: The aim of the present study was to assess the association between COVID-19 vaccination and diabetic ketoacidosis (
DKA) among individuals with T1DM. Additionally, the study aimed to determine the effects of the vaccine on glucose control, variability, and risk of hypoglycemia.
UNASSIGNED: This retrospective study was conducted at King Fahad Specialist Hospital (KFSH) in Qassim Region, Saudi Arabia. Diabetic ketoacidosis cases admitted to the hospital within February 2020 and August 2022 were included in the study based on specific inclusion criteria. Finally, a total of 49 patients were included in statistical analyses.
UNASSIGNED: Out of the 62 patients admitted to the hospital, 49 met the diagnostic criteria for
DKA and agreed to participate in the study. The majority of the remaining patients (n = 13) refused to participate, and only a few of them lacked complete documentation. Of the 49 patients who were included in the study, 46 cases had a history of T1DM; nevertheless, 3 patients were newly diagnosed with T1DM. Additionally, among these participants, 16 (32.7%), 19 (38.8%), and 14 (28.6%) patients had mild, moderate, and severe
DKA, respectively. There were 27 male (55.1%) and 22 female (44.9%) patients. About 91% of the patients were vaccinated against COVID-19, 30.6% of whom were vaccinated within 29 days of being diagnosed with DKA. The pH and bicarbonate levels were observed to be significantly high among those who were diagnosed with
DKA within 29 days of vaccination, with p-values of 0.031 and 0.037, respectively. Similarly, pH and random blood sugar (RBS) were observed to be significantly higher among the vaccinated patients than in the non-vaccinated subjects (P = 0.044 and P = 0.032, respectively).
UNASSIGNED: The study findings revealed that some of the
DKA indicators were evident among the vaccinated patients. However, larger-scale and multi-center studies are recommended in order to have more conclusive evidence and generalize the findings.