PDF(Pubmed)
Abstract：
UNASSIGNED: This retrospective study aimed to use mixed (qualitative and quantitative) methods to evaluate the role of FSL in reducing hospital admissions due to all causes, HbA1c, and reported hypoglycaemic episodes in people with diabetes living in a socially deprived region of Northwest England.
UNASSIGNED: Data were collected retrospectively from previous consultations, which coincided with the 6th -week, 6th -month and annual review including blood tests, hospital admissions due to any cause and reported hypoglycaemia. Also, FSL assessment and satisfaction semi-structured questionnaire was done to assess the impact of FSL on diabetes management and quality of life. Mixed-effects models were used to assess glycaemic control and reductions in hospital admissions and reported hypoglycaemic episodes.
UNASSIGNED: Just 127 patients met the inclusion criteria. A multivariate linear mixed model method that analyses HbA1c data longitudinally revealed mean differences (mmol/mol) between baseline and post-FSL measurements, estimated by restricted maximum likelihood method (REML) of 9.64 (six weeks), 7.68 (six months) and 7.58 (annual review); all with a corresponding p-value of < 0.0001. For DKA patients, the bootstrap method revealed a significant reduction in mean HbA1c of 25.5, 95% confidence interval (CI) [8.8, 42.6] mmol/mol. It is demonstrated that FSL use for one year resulted in 59% reduction in hospital admissions and 46% reduction in reported hypoglycaemic episodes.
UNASSIGNED: The use of FSL resulted in statistically significant reductions in hospital admissions, HbA1c and reported hypoglycaemic episodes among diabetics in a socially deprived Northwest region of England. These outcomes show a direct association with a higher questionnaire score.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s40200-024-01424-4.
UNASSIGNED: Data were collected retrospectively from previous consultations, which coincided with the 6th -week, 6th -month and annual review including blood tests, hospital admissions due to any cause and reported hypoglycaemia. Also, FSL assessment and satisfaction semi-structured questionnaire was done to assess the impact of FSL on diabetes management and quality of life. Mixed-effects models were used to assess glycaemic control and reductions in hospital admissions and reported hypoglycaemic episodes.
UNASSIGNED: Just 127 patients met the inclusion criteria. A multivariate linear mixed model method that analyses HbA1c data longitudinally revealed mean differences (mmol/mol) between baseline and post-FSL measurements, estimated by restricted maximum likelihood method (REML) of 9.64 (six weeks), 7.68 (six months) and 7.58 (annual review); all with a corresponding p-value of < 0.0001. For DKA patients, the bootstrap method revealed a significant reduction in mean HbA1c of 25.5, 95% confidence interval (CI) [8.8, 42.6] mmol/mol. It is demonstrated that FSL use for one year resulted in 59% reduction in hospital admissions and 46% reduction in reported hypoglycaemic episodes.
UNASSIGNED: The use of FSL resulted in statistically significant reductions in hospital admissions, HbA1c and reported hypoglycaemic episodes among diabetics in a socially deprived Northwest region of England. These outcomes show a direct association with a higher questionnaire score.
UNASSIGNED: The online version contains supplementary material available at 10.1007/s40200-024-01424-4.
摘要：
■这项回顾性研究旨在使用混合（定性和定量）方法来评估FSL在减少因各种原因而住院方面的作用，HbA1c,并报告了生活在英格兰西北部社会匮乏地区的糖尿病患者的低血糖事件。
■数据是从以前的咨询中回顾性收集的，恰逢第六周，第6个月和年度审查，包括血液检查，因任何原因入院并报告低血糖。此外，进行FSL评估和满意度半结构化问卷，以评估FSL对糖尿病管理和生活质量的影响。混合效应模型用于评估血糖控制和住院人数减少以及报告的低血糖发作。
■只有127名患者符合纳入标准。纵向分析HbA1c数据的多元线性混合模型方法揭示了基线和FSL后测量之间的平均差（mmol/mol），通过约束最大似然法（REML）估计为9.64（六周），7.68（6个月）和7.58（年度审查）;所有相应的p值<0.0001。对于DKA患者，Bootstrap方法显示平均HbA1c显著降低,为25.5,95%置信区间(CI)[8.8,42.6]mmol/mol.事实证明，使用FSL一年可使住院人数减少59％，报告的低血糖发作减少46％。
■使用FSL导致住院人数在统计学上显着减少，HbA1c和报告的糖尿病患者在英格兰西北部社会贫困地区的低血糖发作。这些结果显示与较高的问卷得分直接相关。
■在线版本包含补充材料，可在10.1007/s40200-024-01424-4获得。
■数据是从以前的咨询中回顾性收集的，恰逢第六周，第6个月和年度审查，包括血液检查，因任何原因入院并报告低血糖。此外，进行FSL评估和满意度半结构化问卷，以评估FSL对糖尿病管理和生活质量的影响。混合效应模型用于评估血糖控制和住院人数减少以及报告的低血糖发作。
■只有127名患者符合纳入标准。纵向分析HbA1c数据的多元线性混合模型方法揭示了基线和FSL后测量之间的平均差（mmol/mol），通过约束最大似然法（REML）估计为9.64（六周），7.68（6个月）和7.58（年度审查）;所有相应的p值<0.0001。对于DKA患者，Bootstrap方法显示平均HbA1c显著降低,为25.5,95%置信区间(CI)[8.8,42.6]mmol/mol.事实证明，使用FSL一年可使住院人数减少59％，报告的低血糖发作减少46％。
■使用FSL导致住院人数在统计学上显着减少，HbA1c和报告的糖尿病患者在英格兰西北部社会贫困地区的低血糖发作。这些结果显示与较高的问卷得分直接相关。
■在线版本包含补充材料，可在10.1007/s40200-024-01424-4获得。
