探讨可再吸收聚乙二醇水凝胶（RPGH，Coseal）对大鼠椎板切除术后硬膜外纤维化（EF）的影响。
将24只大鼠平均分为3组。在第一组中,椎板切除术后不应用治疗(对照组，组1)。在第二组中,椎板切除术后实现止血，将浸泡在盐水中的2mm可吸收明胶海绵放置在硬膜外腔上并闭合伤口(第2组)。在第三组中,椎板切除术后实现止血，和0.5毫升RPGH(Coseal，第3组）被挤压在硬脑膜上，伤口闭合了.进行了组织病理学检查以评估蛛网膜侵入和EF。
与第1组相比，第2组和第3组的EF结果明显更低（分别为p=0.023和p=0.002）。在EF方面，第2组和第3组之间没有发现统计学上的显着差异（p=0.957）。三组平均蛛网膜侵犯率也无统计学差异(p>0.171)。然而,第3组中蛛网膜侵入率最低。
术中封套,聚乙二醇聚合物，倾向于降低硬膜外纤维化的风险，尽管这在统计上并不显著。
To investigate the histopathological effects of reabsorbable polyethylene glycol hydrogel (RPGH,
Coseal) on epidural fibrosis (EF) following laminectomy in rats.
A total of 24 rats were equally divided into three groups. In the first group, no treatment was applied after laminectomy (control group, Group 1). In the second group, hemostasis was achieved after laminectomy, and 2 mm absorbable gelatin sponge soaked in saline was placed over the epidural space and the wound was closed (Group 2). In the third group, hemostasis was achieved following laminectomy, and 0.5 mL RPGH (
Coseal, Group 3) was squeezed over the dura mater, and the wound was closed. A histopathological examination was undertaken to evaluate arachnoidal invasion and EF.
The results of EF in the Group 2 and Group 3 were significantly lower compared to the Group 1 (p = 0.023 and p = 0.002, respectively). No statistically significant difference was found between the Group 2 and Group 3 in terms of EF (p = 0.957). There was also no statistically significant difference between the mean arachnoidal invasion of the three groups (p > 0.171). However, the rate of arachnoidal invasion was the lowest in the Group 3.
Intraoperative
Coseal, a polyethylene glycol polymer, tends to reduce the risk of epidural fibrosis, although this is not statistically significant.
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