肥胖和超重是多种遗传和环境因素共同影响的复杂病症。位于与时钟系统和脂肪味觉感知有关的基因中的几种遗传变异可以影响代谢健康。特别是,据报道,CLOCK和BMAL1基因的多态性与心血管疾病显着相关,代谢综合征,睡眠减少,晚上的偏好。此外,CD36基因的遗传变异已被证明与脂质代谢有关,调节脂肪的摄入,和体重调节。本研究的目的是评估,第一次,一些候选基因中变体之间的关联(即,BMAL1rs7950226(G>A),时钟rs1801260(A>G),时钟rs4864548(G>A),时钟rs3736544(G>A),CD36rs1984112(A>G),孕妇的CD36rs1761667(G>A))和超重/肥胖(OB)。共纳入163名正常体重(NW)和128名OB参与者。CLOCKrs4864548中的A等位基因与肥胖风险增加之间存在显着相关性(OR:1.97;95%CI1.22-3.10,p=0.005)。此外,我们发现携带rs1801260-A单倍型的受试者,rs4864548-A,rs3736544-G可能超重或肥胖(OR1.47,95%CI1.03-2.09,p=0.030),与其他单倍型相比。此外,孕晚期血脂参数与遗传变异之间存在显着关系-即,CD36rs1984112、CD36rs1761667、BMAL1rs7950226和CLOCKrs1801260。多因素logistic回归模型显示,CLOCKrs4864548A等位基因携带是肥胖的重要危险因素(OR2.05,95%CI1.07-3.93,p=0.029);地中海饮食依从性较高(OR0.80,95%CI0.65-0.98,p=0.038)和HDL水平较高(OR0.96,95%CI0.94-0.99,p=0.021)与肥胖风险降低相关.有趣的是,检测到母体CLOCKrs4864548与新生儿出生体重之间存在关联(p=0.025).这些数据表明,多态性在时钟系统和脂肪味觉感知中在超重/肥胖易感性和影响孕妇相关代谢特征方面的潜在作用。
Obesity and overweight are common and complex conditions influenced by multiple genetic and environmental factors. Several genetic variants located in the genes involved in
clock systems and fat taste perception can affect metabolic health. In particular, the polymorphisms in
CLOCK and BMAL1 genes were reported to be significantly related to cardiovascular disease, metabolic syndrome, sleep reduction, and evening preference. Moreover, genetic variants in the CD36 gene have been shown to be involved in lipid metabolism, regulation of fat intake, and body weight regulation. The aim of this study is to evaluate, for the first time, the association between variants in some candidate genes (namely, BMAL1 rs7950226 (G>A), CLOCK rs1801260 (A>G),
CLOCK rs4864548 (G>A),
CLOCK rs3736544 (G>A), CD36 rs1984112 (A>G), CD36 rs1761667 (G>A)) and overweight/obesity (OB) in pregnant women. A total of 163 normal-weight (NW) and 128 OB participants were included. A significant correlation was observed between A-allele in CLOCK rs4864548 and an increased risk of obesity (OR: 1.97; 95% CI 1.22-3.10, p = 0.005). In addition, we found that subjects carrying the haplotype of rs1801260-A, rs4864548-A, and rs3736544-G are likely to be overweight or obese (OR 1.47, 95% CI 1.03-2.09, p = 0.030), compared with those with other haplotypes. Moreover, a significant relation was observed between third-trimester lipid parameters and genetic variants-namely, CD36 rs1984112, CD36 rs1761667, BMAL1 rs7950226, and CLOCK rs1801260. A multivariate logistic regression model revealed that
CLOCK rs4864548 A-allele carriage was a strong risk factor for obesity (OR 2.05, 95% CI 1.07-3.93, p = 0.029); on the other hand, greater adherence to Mediterranean diet (OR 0.80, 95% CI 0.65-0.98, p = 0.038) and higher HDL levels (OR 0.96, 95% CI 0.94-0.99, p = 0.021) were related to a reduced risk of obesity. Interestingly, an association between maternal
CLOCK rs4864548 and neonatal birthweight was detected (p = 0.025). These data suggest a potential role of the polymorphisms in clock systems and in fat taste perception in both susceptibility to overweight/obesity and influencing the related metabolic traits in pregnant women.