引言X射线在医学中广泛用于诊断和治疗。这种有益的用途可能对心导管实验室中的患者和工作人员造成潜在的危险情况。本研究旨在估算导管插入单元不同部位散射的辐射剂量和该单元工人吸收的剂量。以及在伊拉克Duhok市Azadi教学医院接受辐射后接受心脏导管插入程序以评估血液学参数和受损细胞(包含许多染色体畸变的细胞)的所有变化的患者。方法这项研究是在一年内进行的,涉及19名在心导管插入实验室长期暴露于X射线机器的男性工人,45名患者,20名男性和25名女性,在心脏导管插入过程中暴露于较低剂量的X射线。有32个健康个体,19名男性和13名女性,作为一个控制。使用面积监测检测器计算散射辐射。光学受激发光(OSL)剂量计和平板探测器(FPD)用于计算工人和患者的吸收剂量,分别。研究组之间检查了辐射前后的12个血液学参数;细胞遗传学效应,受损细胞,工人白细胞的染色体畸变,导管插入单元的病人,并对对照组个体进行分析。结果结果显示,与开始试验前的数据相比,连续检测一年后的导尿单元中的散射X射线没有显着变化。所有血液参数的结果看起来与对照相比显著不同(p<0.05),但在正常范围内。红细胞血红蛋白无显著性差异(p>0.05),白细胞,红色分布宽度,与对照组相比,暴露一年后工人的中性粒细胞值。此外,白细胞差异无统计学意义(p>0.05),中性粒细胞,手术后患者的单核细胞值。目前的研究表明,工人中受损的细胞与对照组相比有显着差异。同时,暴露1年后,所有工人的差异均不显著(p=0.0962).术后患者受损细胞的差异非常显着(p=0.0003)。本研究表明,双中心的诱导,中心,染色体断裂,人淋巴细胞中的环染色体与辐射剂量密切相关。结论本研究发现,实验结束后导管插入单元中的散射X射线没有明显变化。目前的研究还显示,x光照射对导尿单位的工人和病人的血液指标没有显著影响,而在实验开始时,患者的受损细胞与对照组相比没有显着变化。在患者中,这些细胞在手术后增加,但在工人中存在很高的水平,与对照组相比。工人体内受损的细胞从实验开始到结束都保持不变。最后,与工人相比,在试验期结束后,患者受损细胞增加.
Introduction X-rays are widely used in medicine for diagnosis and treatment. Such beneficial uses may cause potentially hazardous situations for patients and workers in the cardiac catheterization laboratory. The present study aims to estimate the radiation dose scattered in different parts of the catheterization units and doses absorbed by workers in this unit, and patients who underwent cardiac catheterization procedures to evaluate all changes in hematological parameters and damaged cells (the cells that contain a number of chromosomal aberrations) after exposure to radiation at Azadi Teaching Hospital in the Duhok City of Iraq. Methodology The study was conducted in one year and involved 19 male workers chronically exposed to X-ray machines in the cardiac catheterization laboratory, and 45 patients, 20 males and 25 females, who have been exposed to lower doses of X-ray during the cardiac catheterization process. There were 32 healthy individuals, 19 males and 13 females, as a control. Scattered radiation was calculated using an area monitoring detector. Optically Stimulated Luminescence (OSL) dosimeter and Flat Panel Detector (FPD) were used to calculate absorbed doses by workers and patients, respectively. Twelve hematological parameters before and after radiation were examined between study groups; the cytogenetic effects, damaged cells, and chromosomal aberrations of the white blood cells of workers, patients in the catheterization unit, and individuals of the control group were analyzed. Results The results showed that the scattered X-rays in the catheterization unit after one year of continuous detection did not change significantly compared to the data before the start of the trial. The results of all blood parameters looked to be significantly different (p<0.05) compared to the controls but within the normal range. There is no significant difference (p>0.05) in corpuscular hemoglobin, white blood cells, red distribution width, and neutrophil values for workers after one year of exposure as compared with the control. Also, there was no significant difference (p>0.05) in white blood cells, neutrophils, and monocyte values for patients after the operation. The current study showed the damaged cells in workers were significantly different compared to the control. At the same time, the differences were non-significant for all workers (p=0.0962) after one year of exposure. The differences in damaged cells in patients were highly significant after the operation (p=0.0003). The present study demonstrated that the inductions of dicentrics, acentric, chromosome break, and ring chromosomes in human lymphocytes were intimately related to the irradiation dose. Conclusions The present study found that the scattered X-rays in the catheterization unit after the end of the experiment did not change significantly. The current study also revealed that the exposure to X-rays had no significant effects on the blood indicators of workers and patients in the catheterization unit, whereas the damaged cells in patients did not change significantly compared with the control group at the beginning of the experiment. In patients, these cells were increased after the operation but were present at a high level in the workers, as compared with controls. The damaged cells in workers remained constant from the beginning of the experiment till the end. Finally, patients had increased damaged cells after the end of the trial period compared to workers.