背景:以前针灸相关干预在改善化疗引起的周围神经病变(CIPN)症状和生活质量(QoL)方面的效果,在成对比较方面仍不清楚。
目的:本系统综述和网络荟萃分析旨在确定针灸相关干预措施对症状的分级效应,疼痛,接受化疗的癌症患者的QoL与CIPN相关。
方法:搜索了9个电子数据库,包括PubMed,Embase,科克伦图书馆,EBSCO,MedlineOvid,Airiti图书馆,中国国家知识基础设施(CNKI),中国期刊全文数据库(CJFD),还有万方。医学主题标题术语和文本词用于搜索从数据库开始到2023年5月发表的合格随机对照试验。
结果:共纳入33项研究,涉及2,027名参与者。成对荟萃分析显示,针灸相关干预措施优于常规治疗,药物,或膳食补充剂改善CIPN症状,CIPN疼痛,和QoL。此外,网络荟萃分析表明,在各种干预措施中,针刺加电刺激(针灸-E)的总体效果最大.累积排序曲线(SUCRA)下的表面显示,针灸E在改善CINP症状方面排名最高。单纯针刺对减轻CIPN疼痛最有效,针灸(针灸-M)在提高生活质量方面排名最高。
结论:这一发现表明,针灸相关干预措施可以为患者提供改善CIPN症状的益处,疼痛,和QoL。特别是,针灸-E可能是最有效的方法,其中提供的证据为癌症患者和医疗保健专业人员提供了多种选择。
■这些发现为针灸相关干预措施对控制症状的潜在益处提供了有价值的见解。疼痛,化疗患者的QoL与CIPN相关。在研究的各种干预措施中,总的来说,针刺-E具有最显著的影响,且至少持续3周有效.另一方面,经皮穴位电刺激/神经刺激(TEAS)被确定为对针头或出血风险有顾虑的患者的非侵入性和可行的替代方案.建议TEAS干预措施应进行更长的时间,最好持续4周,实现最优结果。
背景:研究方案已在国际前瞻性系统评价注册。
背景:CRD42022319871.
BACKGROUND: The previous effects of acupuncture-related interventions in improving chemotherapy-induced peripheral neuropathy (CIPN) symptoms and quality of life (QoL) remain unclear in terms of pairwise comparisons.
OBJECTIVE: This systematic review and network meta-analysis aimed to determine the hierarchical effects of acupuncture-related interventions on symptoms, pain, and QoL associated with CIPN in cancer patients undergoing chemotherapy.
METHODS: Nine electronic databases were searched, including PubMed, Embase, Cochrane Library, EBSCO, Medline Ovid, Airiti Library, China National Knowledge Infrastructure (CNKI), China Journal full-text database (CJFD), and Wanfang. Medical subject heading terms and text words were used to search for eligible randomized controlled trials published from database inception to May 2023.
RESULTS: A total of 33 studies involving 2,027 participants were included. Pairwise meta-analysis revealed that acupuncture-related interventions were superior to usual care, medication, or dietary supplements in improving CIPN symptoms, CIPN pain, and QoL. Furthermore, network meta-analysis indicated that acupuncture plus electrical stimulation (acupuncture-E) had the greatest overall effect among the various interventions. The surface under the cumulative ranking curve (SUCRA) revealed that acupuncture-E ranked the highest in improving CINP symptoms. Acupuncture alone was most effective in reducing CIPN pain, and acupuncture plus moxibustion (acupuncture-M) ranked highest in enhancing QoL.
CONCLUSIONS: This finding suggests that acupuncture-related interventions can provide patients with benefits in improving CIPN symptoms, pain, and QoL. In particular, acupuncture-E could be the most effective approach in which the provided evidence offers diverse options for cancer patients and healthcare professionals.
UNASSIGNED: These findings provide valuable insights into the potential benefits of acupuncture-related interventions for managing symptoms, pain, and QoL associated with CIPN in patients undergoing chemotherapy. Among the various interventions studied, overall, acupuncture-E had the most significant impact and was effective for a minimum duration of 3 weeks. On the other hand, transcutaneous electrical acupoint/nerve stimulation (TEAS) was identified as a noninvasive and feasible alternative for patients who had concerns about needles or the risk of bleeding. It is recommended that TEAS interventions should be carried out for a longer period, preferably lasting 4 weeks, to achieve optimal outcomes.
BACKGROUND: The study protocol was registered in the International Prospective Register of Systematic Reviews.
BACKGROUND: CRD42022319871.