■超过一半的癌症患者会出现严重的化疗引起的周围神经病变(CIPN),导致生活质量低下,对功能的负面影响,以及治疗依从性方面的挑战。最近的研究表明,运动疗法对减轻CIPN症状有积极影响,还可以改善生活质量。balance,和活动水平。这项荟萃分析的目的是评估运动疗法对CIPN疗效的影响。
■Embase的计算机搜索,WebofScience,CNKI,万方数据,VIP,从数据库创建到2022年11月,CIPN运动疗法RCT的CBM,不受语言限制。使用CochraneHandbook5.3偏倚风险评估工具评估纳入研究的质量。采用Revman5.3软件对纳入研究进行质量评价。研究结果的异质性通过I2检验,连续变量以加权平均差或标准平均差表示,置信区间设定为95%。Stata15.0用于进行荟萃分析。
■共纳入15项RCT,共1,124例患者。Meta分析显示试验组在总症状评分(SMD:-0.62;95%Cl:-0.99,-0.24)方面优于对照组,麻木,刺痛,生活质量评分(总分,物理,函数),疼痛,balance,和神经毒性功能评估(FACT/GOG-NTX)问卷(p<0.05)。
■每周治疗的持续时间和频率都不同,这可能会对结果产生一些影响。
■运动疗法可以通过改善症状评分(总症状评分,麻木,刺痛),生活质量评分(总分,物理功能),疼痛,balance,和FACT/GOG-NTX问卷。它还需要更多高质量的完善和验证,多中心,未来的大样本RCT。
■https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42022373131,标识符:CRD42022373131。
More than half of cancer patients develop severe chemotherapy-induced peripheral neuropathy (CIPN), resulting in low quality of life, negative effects on function, and challenges in treatment compliance. Most recent studies have shown that exercise therapy has a positive impact on reducing CIPN symptoms and can also improve quality of life, balance, and activity levels. The aim of this meta-analysis was to evaluate the effect of exercise therapy on the efficacy of CIPN.
Computerized search of Embase, Web of Science, CNKI, Wan Fang Data, VIP, CBM for RCTs on exercise therapy for CIPN from database creation to November 2022, without language restriction. The Cochrane Handbook 5.3 risk of bias assessment tool was used to evaluate the quality of the included studies. Then Revman 5.3 software was used to evaluate the quality of the included studies. The heterogeneity of the research results is tested by I2, continuous variables were presented as weighted mean difference or standard mean difference, and confidence intervals were set at 95%. Stata15.0 was utilized to conduct a meta-analysis.
A total of 15 RCTs with 1,124 patients were included. Meta-analysis showed that the test group was superior to the control group in terms of total symptom score (SMD: -0.62; 95% Cl: -0.99, -0.24), numbness, tingling, quality of life score (total score, physical, function), pain, balance, and neurotoxicity function assessment (FACT/GOG-NTX) questionnaire (p < 0.05).
The duration and frequency of treatment are different every week, which may have some impact on the results.
Exercise therapy can be effective in treating CIPN by improving symptom score (total symptom score, numbness, tingling), quality of life score (total score, physical function), pain, balance, and FACT/GOG-NTX questionnaires. It still needs to be refined and validated by more high-quality, multicenter, large-sample RCTs in the future.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022373131, identifier: CRD42022373131.