目的:本荟萃分析旨在阐明TNF-α-308G>A和-238G>A多态性与肺癌风险之间的关联。
方法:在PubMed、谷歌学者,WebofScience,EMBASE,和CNKI,到2023年9月25日。通过计算比值比(OR)及其95%置信区间(CI)来评估肺癌风险。Z检验用于确定组合OR的显著性,P<0.05被认为具有统计学意义。所有分析均采用综合Meta分析(CMA)2.0软件进行。
结果:分析包括19个病例对照研究,其中3,838例和5,306个对照的TNF-α-308G>A多态性,以及10项研究,包括-238G>A多态性的2,427例和2,357例对照。-308G>A多态性没有显著的总体关系,尽管在亚洲分组中,与G相比,A等位基因显着减少(OR:0.831,p=0.028),AA基因型与GG相比显着减少(OR:0.571,p=0.021),在白种人中没有显着相关性。在非小细胞肺癌(NSCLC)中,与G相比,A等位基因与风险增加相关(OR:1.131,p=0.049).对于-238G>A多态性,与GG相比,AA基因型的风险显着增加(OR:3.171,p=0.014),同时在高加索人中显示出保护作用(OR:0.120,p=0.024),在亚洲人中显示出更高的风险(OR:7.990,p=0.007)。在小细胞肺癌(SCLC)中,A等位基因赋予了保护作用,而NSCLC显示AA基因型风险增加(OR:11.375,p=0.002).
结论:-308G>A多态性没有显著的总体关系,但表明A等位基因在亚洲亚组中具有保护作用。相反,-238G>A多态性呈现复杂的风险特征,在保护白种人的同时增加亚洲人患肺癌的可能性。值得注意的是,AA基因型显著增加NSCLC的风险,表明其作为风险因素的潜力。
OBJECTIVE: This meta-analysis aims to clarify the association between the TNF-α -308G > A and - 238G > A polymorphisms and lung cancer risk.
METHODS: A comprehensive search was conducted for relevant articles across databases such as PubMed, Google Scholar, Web of Science, EMBASE, and CNKI, up to September 25, 2023. Lung cancer risk was assessed by calculating odds ratios (ORs) and their 95% confidence intervals (CIs). The Z-test was used to determine the significance of combined ORs, with P < 0.05 considered statistically significant. All analyses were performed using Comprehensive Meta-Analysis (CMA) 2.0 software.
RESULTS: The analysis included 19 case-control studies with 3,838 cases and 5,306 controls for the TNF-α -308G > A polymorphism, along with 10 studies comprising 2,427 cases and 2,357 controls for the - 238G > A polymorphism. The - 308G > A polymorphism showed no significant overall relationships, though in the Asian subgroup, the A allele was significantly reduced compared to G (OR: 0.831, p = 0.028) and the AA genotype showed significant reductions versus GG (OR: 0.571, p = 0.021), with no significant correlation in Caucasians. In non-small cell lung cancer (NSCLC), the A allele was associated with increased risk compared to G (OR: 1.131, p = 0.049). For the - 238G > A polymorphism, the AA genotype significantly increased risk compared to GG (OR: 3.171, p = 0.014), while showing a protective effect in Caucasians (OR: 0.120, p = 0.024) and a heightened risk in Asians (OR: 7.990, p = 0.007). In small cell lung cancer (SCLC), the A allele conferred protective effects, whereas NSCLC showed increased risk for the AA genotype (OR: 11.375, p = 0.002).
CONCLUSIONS: The - 308G > A polymorphism has no significant overall relationships but suggests a protective role of the A allele in the Asian subgroup. Conversely, the - 238G > A polymorphism presents a complex risk profile, increasing lung cancer likelihood in Asians while protecting Caucasians. Notably, the AA genotype significantly raises risk for NSCLC, indicating its potential as a risk factor.