■帕金森病(PD)患者出现视觉症状和视网膜变性。使用光学相干断层扫描(OCT)的研究表明,PD中视网膜的厚度减小,也是青光眼的关键特征。
■为了确定视网膜从头变化的存在和模式,与健康对照(HC)和早期原发性开角型青光眼(POAG)患者相比,未治疗的PD患者。
■从HC收集黄斑OCT数据(10×10mm),PD,和早期POAG患者,格罗宁根大学医学中心.贝叶斯信息假设进行了统计分析,比较了HC,PD-,和POAG患者,在每个视网膜细胞层内。
■总共100HC,121PD,共纳入78例POAG患者。与HC相比,我们发现PD中的内部丛状层和视网膜色素上皮的厚度显着降低。POAG患者的视网膜神经纤维层明显变薄,神经节细胞层,内丛状层,外丛状层,以及与PD相比的外光感受器和视网膜下虚拟空间。与POAG相比,PD中只有外节层和视网膜色素上皮显着变薄。
■与HC相比,从头PD患者的视网膜厚度减小,尤其是内部的丛状层,这与POAG有很大不同,显示出更广泛和更广泛的跨层厚度减小的模式。OCT是一个有用的工具来检测视网膜变化在从头PD,但它相对于其他神经退行性疾病的特异性必须建立。
UNASSIGNED: Parkinson\'s disease (PD) patients experience visual symptoms and retinal degeneration. Studies using optical coherence tomography (OCT) have shown reduced thickness of the retina in PD, also a key characteristic of glaucoma.
UNASSIGNED: To identify the presence and pattern of retinal changes in de novo, treatment-naive PD patients compared to healthy controls (HC) and early primary open angle glaucoma (POAG) patients.
UNASSIGNED: Macular OCT data (10×10 mm) were collected from HC, PD, and early POAG patients, at the University Medical Center Groningen. Bayesian informative hypotheses statistical analyses were carried out comparing HC, PD-, and POAG patients, within each retinal cell layer.
UNASSIGNED: In total 100 HC, 121 PD, and 78 POAG patients were included. We showed significant reduced thickness of the inner plexiform layer and retinal pigment epithelium in PD compared to HC. POAG patients presented with a significantly thinner retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, outer plexiform layer, and outer photoreceptor and subretinal virtual space compared to PD. Only the outer segment layer and retinal pigment epithelium were significantly thinner in PD compared to POAG.
UNASSIGNED: De novo PD patients show reduced thickness of the retina compared to HC, especially of the inner plexiform layer, which differs significantly from POAG, showing a more extensive and widespread pattern of reduced thickness across layers. OCT is a useful tool to detect retinal changes in de novo PD, but its specificity versus other neurodegenerative disorders has to be established.