■关于肥胖与年龄相关性白内障(ARC)之间的关系的发现不一致。通过对符合条件的前瞻性队列研究进行剂量反应荟萃分析,本系统综述旨在总结肥胖[由体重指数(BMI)定义]与ARC之间关联的现有发现。
■我们在PubMed中进行了系统搜索,Scopus,ISIWebofKnowledge,和谷歌学者在2022年6月之前确定合格的出版物。
■总共,包括16项研究,总样本量为1,607,125名参与者。在所有这些研究中,有103897例ARC.在4至28年的随访期内,4,870例核性白内障,1,611例皮质性白内障,共检出1,603例后囊下白内障(PSC)。通过比较BMI的最高和最低类别,我们发现,较高的BMI与ARC(RR:1.18,95%CI:1.09~1.28)和PSC(RR:1.44,95%CI:1.08~1.90)的风险增加相关.在剂量反应分析中,BMI每增加5kg/m2与ARC(RR:1.06,95%CI:1.01-1.12)和PSC(RR:1.27,95%CI:1.14-1.41)的风险增加6%和27%,分别。此外,在高质量研究中,我们发现皮质性白内障呈正相关,其中较高的BMI与皮质性白内障风险增加20%相关(RR:1.20,95%CI:1.02-1.42).就核性白内障而言,我们在BMI最高和最低类别之间的比较或剂量-反应荟萃分析中没有发现显著相关性.
■肥胖(由BMI定义)与ARC风险增加相关,PSC,和成人的皮质性白内障。然而,在核性白内障中未发现这种正相关。
■CRD42022357132。
UNASSIGNED: There are inconsistent findings on the association between obesity and age-related cataract (ARC). This systematic review was done to summarize available findings on the association between obesity [defined by body mass index (BMI)] and ARC by performing a dose-response meta-analysis on eligible prospective cohort studies.
UNASSIGNED: We performed a systematic search in PubMed, Scopus, ISI Web of Knowledge, and Google Scholar until June 2022 to identify eligible publications.
UNASSIGNED: In total, 16 studies with a total sample size of 1,607,125 participants were included. Among all of these studies, there were 103,897 cases of ARC. In the follow-up periods ranging between 4 and 28 years, 4,870 cases of nuclear cataract, 1,611 cases of cortical cataract, and 1,603 cases of posterior subcapsular cataracts (PSC) were detected. By comparing the highest and lowest categories of BMI, we found that higher BMI was associated with an increased risk of ARC (RR: 1.18, 95% CI: 1.09-1.28) and PSC (RR: 1.44, 95% CI: 1.08-1.90). In the dose-response analysis, each 5 kg/m2 increase in BMI was associated with a 6 and 27% increased risk of ARC (RR: 1.06, 95% CI: 1.01-1.12) and PSC (RR: 1.27, 95% CI: 1.14-1.41), respectively. In addition, we found a positive association for cortical cataract among high-quality studies, in which higher BMI was associated with a 20% increased risk of cortical cataract (RR: 1.20, 95% CI: 1.02-1.42). In terms of nuclear cataract, we found no significant association either in the comparison between the highest and lowest categories of BMI or in the dose-response meta-analysis.
UNASSIGNED: Obesity (defined by BMI) was associated with an increased risk of ARC, PSC, and cortical cataract in adults. However, such a positive association was not seen for nuclear cataract.
UNASSIGNED: CRD42022357132.