■瑞典成年男性的癌症风险增加与切尔诺贝利事故对结肠的吸收剂量增加有关。
■一个封闭队列,有猎人身份的信息,包括1986年生活在瑞典北部的所有个人。共有2,104,101人获得了有关在住宅坐标处接触137Cs的完整年度信息。一种巢式病例对照方法,四个对照匹配癌症诊断年份和出生年份,被使用。在1986年至2020年之间计算了个体器官吸收剂量,包括外部和内部暴露。使用针对农村/非农村栖息地调整后的条件逻辑回归计算每mGy的危害比(HR)和95%置信区间(95%CI)。1980年至1985年的教育水平和切尔诺贝利前癌症发病率。共纳入男性161,325例癌症病例和女性144,439例癌症病例。
■所有癌症部位合并的每mGy的校正HR在男性中为1.027(95%CI=1.022,1.031),在女性中为1.011(95%CI=1.006,1.017)。在事后分析中,考虑了猎人生活方式和县切尔诺贝利前癌症发病率的混淆,所有合并癌症部位的校正HR/mGy男性为1.014(95%CI=1.009,1.019),女性为1.000(95%CI=0.994,1.006).事后分析表明结肠癌的风险增加,胰腺,和胃,分别,在男性中,女性淋巴瘤。
■发现某些特定癌症部位的癌症风险估计增加,但不能排除由于猎人的生活方式而导致的不受控制的混杂因素。
UNASSIGNED: Adult males in Sweden exhibit an increased risk of cancer associated with an increased absorbed dose to the colon from the Chernobyl accident.
UNASSIGNED: A closed cohort, with information on hunter status, included all individuals living in northern Sweden in 1986. Complete annual information on exposure to
137Cs at the dwelling coordinate was available for a total of 2,104,101 individuals. A nested case-control method with four controls matched for year of cancer diagnosis and year of birth, was used. Individual absorbed organ doses were calculated between 1986 and 2020 including external and internal exposure. Hazard ratios (HR) per mGy with 95% confidence intervals (95% CI) were calculated using conditional logistic regression adjusted for rural/nonrural habitat, education level and pre-Chernobyl cancer incidence 1980 to 1985. A total of 161,325 cancer cases in males and 144,439 in females were included.
UNASSIGNED: The adjusted HR per mGy for all cancer sites combined was 1.027 (95% CI = 1.022, 1.031) in males and 1.011 (95% CI = 1.006, 1.017) in females. In a post hoc analysis accounting for both remaining confounding from hunter lifestyle and the pre-Chernobyl cancer incidence by county, the adjusted HR per mGy for all cancer sites combined was 1.014 (95% CI = 1.009, 1.019) in males and 1.000 (95% CI = 0.994, 1.006) in females. The post hoc analysis suggested an increased risk of cancer in the colon, pancreas, and stomach, respectively, in males, and lymphoma in females.
UNASSIGNED: Increased cancer risk estimates were found for some specific cancer sites but remaining uncontrolled confounding due to hunter lifestyle could not be ruled out.