■血栓形成合并妊娠对不良妊娠结局构成重大风险。不幸的是,没有预测不良妊娠结局的高危指标.这项研究调查了血清免疫炎症标志物对不良妊娠结局的预测效率。
这项回顾性队列研究包括2022年1月至2024年4月在福建省省立医院南分院分娩的223名被诊断患有血栓形成倾向的孕妇。收集临床资料和妊娠结局。全身免疫炎症指数(SII),全身炎症反应指数(SIRI),使用血液样本计算乳酸脱氢酶(LDH)。分析免疫炎症标志物与不良妊娠结局的关系及预测准确性。
■在这项研究中,50例(22.4%)患者有不良妊娠结局。观察到中性粒细胞计数存在显着差异,单核细胞计数,LDH,SII,不良妊娠结局组(APOs)与对照组的SIRI水平差异有统计学意义(P<0.05)。受试者工作特征(ROC)曲线下面积分析显示SII(AUC=0.762),SIRI(AUC=0.764),和LDH(AUC=0.732)对不良妊娠结局具有较高的预测值。值得注意的是,组合模型的AUC最高,为0.805.多变量逻辑回归确定的SII具有最高的奇数比(OR)(OR=8.512;95%CI(3.068-23.614)),其次是LDH(OR=4.905;95%CI(1.167-11.101)),SIRI(OR=3.549;95%CI(0.847-8.669)),和中性粒细胞计数(OR=1.726;95%CI(0.563-2.938))是不良结局的独立危险因素。
■SII等免疫炎症标志物水平升高,SIRI,和LDH水平是血栓形成合并妊娠不良妊娠结局的强预测因子.这些标记与母婴结局显着相关。我们的发现强调了监测患有血栓形成倾向的孕妇的免疫炎症标志物以改善母婴结局的重要性。
UNASSIGNED: Thrombophilia combined with pregnancy poses significant risks for adverse pregnancy outcomes. Unfortunately, there are no indicators at high risk for predicting adverse pregnancy outcomes. This study investigates the predictive efficiency of serum immune-inflammatory markers on adverse pregnancy outcomes.
UNASSIGNED: This retrospective cohort study includes 223 pregnant women diagnosed with
thrombophilia who delivered at the Fujian Provincial Hospital South Branch from January 2022 to April 2024. Clinical information and pregnancy outcomes were collected. The systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and lactate dehydrogenase (LDH) were calculated using blood samples. The relationship and predictive accuracy between immune-inflammatory markers and adverse pregnancy outcomes were analyzed.
UNASSIGNED: In this study, 50 (22.4%) patients had adverse pregnancy outcomes. Significant differences were observed in neutrophils counts, monocytes counts, LDH, SII, and SIRI levels between the adverse pregnancy outcome groups (APOs) and the control groups (P<0.05). The area under the receiver operating characteristic (ROC) curve analysis revealed that SII (AUC=0.762), SIRI (AUC=0.764), and LDH (AUC=0.732) had high predictive values for adverse pregnancy outcomes. Notably, the combined model had the highest AUC of 0.805. Multivariate logistic regression identified SII had the highest odd ratio (OR) (OR=8.512; 95% CI(3.068-23.614)), followed by LDH (OR=4.905; 95% CI (1.167-11.101)), SIRI (OR=3.549; 95% CI(0.847-8.669)), and neutrophils count (OR=1.726; 95% CI (0.563-2.938)) as independent risk factors for adverse outcomes.
UNASSIGNED: Elevated levels of immune-inflammatory markers such as SII, SIRI, and LDH level are strong predictors of adverse pregnancy outcomes in
thrombophilia-complicated pregnancies. These markers are significantly associated with maternal-neonatal outcomes. Our findings underscore the importance of monitoring immune-inflammatory markers in pregnant women with
thrombophilia to improve maternal and neonatal outcomes.