METHODS: PubMed and Scopus were systematically searched for pertinent prospective studies. Relative risks (RR) and 95% confidence intervals (CI) were used to test the association. Sixteen studies, with 16,174 participants, were included.
RESULTS: Carriers of the G20210 A mutation were at increased risk of recurrent VTE (RR = 1.60, 95% CI = 1.20-2.14) compared to noncarriers; the increased risk was observed in heterozygotes (GA versus GG) (RR = 1.79, 95% CI = 1.24-2.57), but not in GA/AA mutation.
CONCLUSIONS: This association was found to be significant in the long term (≥5 years of follow-up), but not in the short term (<5 years of follow-up).
方法:系统搜索PubMed和Scopus进行相关的前瞻性研究。使用相对风险(RR)和95%置信区间(CI)来检验相关性。16项研究,有16174名参与者,包括在内。
结果:G20210A突变携带者VTE复发风险增加(RR=1.60,95CI=1.20-2.14),与非携带者相比;在杂合子中观察到风险增加(GA与GG)(RR=1.79,95CI=1.24-2.57),但不是在GA/AA突变。
结论:发现这种关联在长期(≥5年的随访)中是显著的,但不是在短期(<5年的随访)。