Abstract：
OBJECTIVE: The prothrombin (PT) G20210A mutation is one of the most prevalent genetic variations associated with an increased susceptibility to the first episode of venous thromboembolism (VTE). However, it remains uncertain whether this inherited thrombophilic abnormality also poses a risk for recurrent VTE. This meta-analysis aimed to assess the relation of PT G20210A mutation to the risk of recurrent VTE.
METHODS: PubMed and Scopus were systematically searched for pertinent prospective studies. Relative risks (RR) and 95% confidence intervals (CI) were used to test the association. Sixteen studies, with 16,174 participants, were included.
RESULTS: Carriers of the G20210 A mutation were at increased risk of recurrent VTE (RR = 1.60, 95% CI = 1.20-2.14) compared to noncarriers; the increased risk was observed in heterozygotes (GA versus GG) (RR = 1.79, 95% CI = 1.24-2.57), but not in GA/AA mutation.
CONCLUSIONS: This association was found to be significant in the long term (≥5 years of follow-up), but not in the short term (<5 years of follow-up).
METHODS: PubMed and Scopus were systematically searched for pertinent prospective studies. Relative risks (RR) and 95% confidence intervals (CI) were used to test the association. Sixteen studies, with 16,174 participants, were included.
RESULTS: Carriers of the G20210 A mutation were at increased risk of recurrent VTE (RR = 1.60, 95% CI = 1.20-2.14) compared to noncarriers; the increased risk was observed in heterozygotes (GA versus GG) (RR = 1.79, 95% CI = 1.24-2.57), but not in GA/AA mutation.
CONCLUSIONS: This association was found to be significant in the long term (≥5 years of follow-up), but not in the short term (<5 years of follow-up).
摘要：
目的：凝血酶原（PT）G20210A突变是与静脉血栓栓塞症（VTE）首次发作易感性增加相关的最普遍的遗传变异之一。然而,目前尚不确定这种遗传性血栓性异常是否也会带来VTE复发的风险.这项荟萃分析旨在评估PTG20210A突变与复发性VTE风险的关系。
方法：系统搜索PubMed和Scopus进行相关的前瞻性研究。使用相对风险（RR）和95％置信区间（CI）来检验相关性。16项研究，有16174名参与者，包括在内。
结果：G20210A突变携带者VTE复发风险增加（RR=1.60，95CI=1.20-2.14），与非携带者相比；在杂合子中观察到风险增加(GA与GG）（RR=1.79，95CI=1.24-2.57），但不是在GA/AA突变。
结论：发现这种关联在长期（≥5年的随访）中是显著的，但不是在短期（<5年的随访）。
方法：系统搜索PubMed和Scopus进行相关的前瞻性研究。使用相对风险（RR）和95％置信区间（CI）来检验相关性。16项研究，有16174名参与者，包括在内。
结果：G20210A突变携带者VTE复发风险增加（RR=1.60，95CI=1.20-2.14），与非携带者相比；在杂合子中观察到风险增加(GA与GG）（RR=1.79，95CI=1.24-2.57），但不是在GA/AA突变。
结论：发现这种关联在长期（≥5年的随访）中是显著的，但不是在短期（<5年的随访）。
