UNASSIGNED:常规八段锦运动干预被证明对改善不同健康状况的老年人的认知能力和身体表现有益,但不清楚如何影响海马的结构可塑性。本研究旨在探讨海马亚区的调节是八段锦运动改善老年人认知虚弱的机制。
UNASSIGNED:共招募了102名认知虚弱的社区居住老年人,并随机分配到八段锦运动训练组和常规身体活动对照组。八段锦运动训练组的参与者参加了为期24周的八段锦运动干预计划,运动频率为每天60分钟,每周3天。评估认知能力和身体虚弱,在基线和干预24周后对所有参与者进行MRI扫描.用MRIConvert处理结构MRI数据(版本2.0Rev.235)和FreeSurfer(6.0.0版)软件。使用独立样本t检验/Mann-WhitneyU检验与Bonferroni校正进行数据分析,混合线性模型,相关性,或通过SPSS24.0软件进行中介分析(IBMCorp,Armonk,NY,美国)。
未经评估:干预24周后,发现蒙特利尔认知评估(MoCA)得分(p=0.002)具有较大的效应大小(Cohen\sd=0.94)和显着的交互效应(Pgoup×时间<0.05),记忆商(MQ)得分(p=0.019)具有中等效应大小(Cohen'sd=0.688)和显着的交互效应(Pgoup×时间<0.05),和WMS-RC测试的其他参数,包括图片(p=0.042),识别(p=0.017),八段锦训练组的中等效应大小(Cohens\'d=0.592、0.703和0.581)和关联(p=0.045)检验,虽然埃德蒙顿衰弱量表(EFS)得分显着下降(p=0.022),八段锦训练组具有中等效应大小(科恩d=-0.659)和显著的交互效应(Pgoup×时间<0.05)。左下伞的差异,海马杏仁核过渡区(HATA),从基线到干预后24周,八段锦训练组的右CornuAmmonisSubfield1(CA1)和前膜体积均显着大于对照组(p<0.05/12)。进一步分析表明,右侧CA1体积的变化与MoCA和MQ评分的变化呈正相关(r=0.510,p=0.015;r=0.484,p=0.022;),右前下丘和左下丘体积的变化与MQ(r=0.435,p=0.043)和图片测试成绩(r=0.509,p=0.016)的变化呈正相关,分别,而八段锦训练组左下、HATA体积的变化与EFS分数的变化呈负相关(r=-0.534,p=0.011;r=-0.575,p=0.005),即使在调整了年龄之后,性别,受教育年限和婚姻状况;此外,左下和左HATA的体积变化显着介导了八段锦运动训练引起的EFS得分的降低(β=0.376,95%CI0.024〜0.947;β=0.484,95%CI0.091〜0.995);左下和右CA1的变化显着介导了八段锦运动训练引起的图片和MO得分的增加(β=-0.83,〜95%,β-2.99-CI=
UNASSIGNED:24周的八段锦运动干预有效地改善了社区居住的老年人的认知能力并减少了身体的虚弱,其机制可能与调节海马亚区的结构可塑性有关。
UNASSIGNED: Regular Baduanjin exercise intervention was proven to be beneficial in improving the cognitive ability and physical performance of older adults with different health conditions but was unclear to influence the structural plasticity of the hippocampus. This study aimed to explore the modulation of hippocampal subregions as a mechanism by which Baduanjin exercise improves cognitive frailty in older adults.
UNASSIGNED: A total of 102 community-dwelling older adults with cognitive frailty were recruited and randomly allocated to the Baduanjin exercise training group and usual physical activity control group. The participants in the Baduanjin exercise training group participated in a 24-week Baduanjin exercise intervention program with an exercise frequency of 60 min per day, 3 days per week. Cognitive ability and physical frailty were assessed, and MRI scans were performed on all participants at baseline and after 24 weeks of intervention. The structural MRI data were processed with MRIConvert (version 2.0 Rev. 235) and FreeSurfer (version 6.0.0) software. Data analyses were performed using the independent sample t tests/Mann-Whitney U tests with the Bonferroni correction, mixed linear model, correlation, or mediation analysis by the SPSS 24.0 software (IBM Corp, Armonk, NY, United States).
UNASSIGNED: After 24 weeks of intervention, a statistically significant increase was found for the Montreal Cognitive Assessment (MoCA) scores (p = 0.002) with a large effect size (Cohen\'s d = 0.94) and the significant interaction effect (P goup × time < 0.05), Memory Quotient (MQ) scores (p = 0.019) with a medium effect size (Cohen\'s d = 0.688) and the significant interaction effect (P goup × time < 0.05), and other parameters of WMS-RC test including pictures (p = 0.042), recognition (p = 0.017), and association (p = 0.045) test with a medium effect size (Cohens\' d = 0.592, 0.703, and 0.581) for the Baduanjin training group, while significant decrease for the Edmonton Frailty Scale (EFS) score (p = 0.022), with a medium effect size (Cohen\'s d = -0.659) and the significant interaction effect (P goup × time < 0.05) for the Baduanjin training group. The differences in the left parasubiculum, Hippocampal Amygdala Transition Area (HATA), right Cornu Ammonis Subfield 1 (CA1) and presubiculum volumes from baseline to 24 weeks after intervention in the Baduanjin training group were significantly greater than those in the control group (p < 0.05/12). Further analysis showed that the changes in right CA1 volume were positively correlated with the changes in MoCA and MQ scores (r = 0.510, p = 0.015; r = 0.484, p = 0.022;), the changes in right presubiculum and left parasubiculum volumes were positively correlated with the changes in MQ (r = 0.435, p = 0.043) and picture test scores (r = 0.509, p = 0.016), respectively, and the changes in left parasubiculum and HATA volumes were negatively correlated with the changes in EFS scores (r = -0.534, p = 0.011; r = -0.575, p = 0.005) in the Baduanjin training group, even after adjusting for age, sex, years of education and marital status; furthermore, the volume changes in left parasubiculum and left HATA significantly mediated the Baduanjin exercise training-induced decrease in the EFS scores (β = 0.376, 95% CI 0.024 ~ 0.947; β = 0.484, 95% CI 0.091 ~ 0.995); the changes of left parasubiculum and right CA1 significantly mediated the Baduanjin exercise training-induced increase in the picture and MO scores (β = -0.83, 95% CI-1.95 ~ -0.002; β = -2.44, 95% CI-5.99 ~ -0.32).
UNASSIGNED: A 24-week Baduanjin exercise intervention effectively improved cognitive ability and reduced physical frailty in community-dwelling older adults with cognitive frailty, and the mechanism might be associated with modulating the structural plasticity of the hippocampal subregion.