龋齿和牙周病是肾脏疾病患者常见的典型口腔疾病。牙齿脱落是龋齿和牙周病的结果,现有牙齿的数量是口腔健康状况的指标。然而,现有牙齿数量与终末期肾病(ESKD)之间的关联尚未详细研究.本研究旨在调查口腔健康状况之间的关系,用现有牙齿的数量来表示,和ESKD。我们分析了第二次多相纵向评估调查的数据,牙齿学,和牙医的营养协会,在日本牙科协会成员中进行的一项队列研究.从2016年8月到2017年7月,自我管理的问卷被邮寄给16,128名男性牙医和8,722个答复。其中,7479名男性,有完整的年龄数据,现有牙齿的数量,和ESKD纳入分析。进行多因素logistic回归分析,以ESKD为因变量,现有齿数(≥23齿和<23齿)为自变量。按年龄(<65岁和≥65岁)进行亚组分析。<23颗牙齿组的ESKD发生率明显高于≥23颗牙齿组。在调整了年龄之后,身体质量指数,吸烟习惯,高血压,和糖尿病,在所有参与者中,<23颗牙齿与ESKD之间没有显著关联.然而,亚组分析显示,在年龄<65岁的参与者中,校正协变量后存在显著关联,但在年龄≥65岁的参与者中没有相关性.总之,在年龄<65岁的日本男性中,牙齿<23颗与需要维持性透析治疗的风险相关.因此,牙齿脱落可能与肾功能下降有关。
Dental caries and periodontal disease are typical oral diseases frequently observed in patients with renal diseases. Tooth loss is an outcome of dental caries and periodontal disease, and the number of existing teeth is an indicator of oral health status. However, the association between the number of existing teeth and end-stage kidney disease (ESKD) has not been investigated in detail. This study aimed to investigate the association between oral health status, expressed by the number of existing teeth, and ESKD. We analyzed data from the second survey of the Longitudinal Evaluation of Multi-phasic, Odontological, and Nutritional Associations in Dentists, a cohort study conducted among members of the Japan Dental Association. From August 2016 to July 2017, self-administered questionnaires were mailed to 16,128 male dentists and 8,722 responded. Among them, 7,479 men with complete data on age, number of existing teeth, and ESKD were included in the analysis. Multivariate logistic regression analysis was conducted, with ESKD as the dependent variable and the number of existing teeth (≥23 teeth and <23 teeth) as the independent variable. Subgroup analysis by age (<65 years and ≥65 years) was also conducted. The <23 teeth group had a significantly higher rate of ESKD than did the ≥23 teeth group. After adjusting for age, body mass index, smoking habits, hypertension, and diabetes mellitus, there was no significant association between having <23 teeth and ESKD in all participants. However, the subgroup analysis revealed a significant association after adjustment for covariates in participants aged <65 years but not in those aged ≥65 years. In conclusion, having <23 teeth was associated with the risk of requiring maintenance dialysis therapy among Japanese men aged <65 years. Therefore, tooth loss may be associated with renal function decline.