背景:虽然学校筛查发现有视力问题的儿童,并在眼科医院转诊,这种方法的有效性仍未得到证实。
目的:探讨眼科临床服务对患有视力障碍的学龄前儿童近视发生和发展的影响。
方法:使用来自上海儿童和青少年大规模眼科研究(SCALE)的数据,这项回顾性队列研究评估了来自静安三个地区的儿童的视觉发育,闵行,和浦东-代表了上海17个地区的地理多样性和经济差距。最初,2015年,这项研究涵盖了14572名4-6岁的儿童,其中5917人需要转诊。我们的队列由5,511名儿童组成,他们在2015年1月至2020年12月的随访期内进行了两次或更多次视力筛查和完整的个人信息。我们根据这些儿童的初始球面当量(SE)将其分为两组:高风险组(SE>-0.5D)和近视组(SE≤-0.5D)。在这些群体中,我们进一步将儿童分类为“从不”,迟钝,并根据其转诊依从性及时分组比较近视发生和进展的差异。Cox比例模型用于估计高危人群中每人每年随访的近视发生率的风险比(HR)。使用广义累加模型(GAM)来计算所有儿童的年度球形等效变化的进展。
结果:在5,511名学龄前儿童中(平均年龄,5.25岁;52.24%男性)接受转诊推荐,1327人(24.08%)在一家眼科医院寻求临床服务。经过六年的随访,65.53%的儿童发展为近视。Never中近视眼的六年累计发病率,迟钝,及时组为64.76%,69.31%,和57.14%,分别。这些百分比对应于延迟组的1.31(95%CI,1.10-1.55)和及时组的0.55(95%CI,0.33-0.93)的风险比(HR),与Never组相比。HR根据年龄进行了调整,性别,和SE在研究进入。有趣的是,及时组的SE进展明显少于其他组(P<0.001),高危人群的SE进展(-0.33±0.37D/年)高于近视儿童(-0.08±0.55D/年)。
结论:在学校视力筛查失败的4至6岁儿童中,及时使用眼科临床服务可以显着降低近视的发生率并减缓SE的进展。
BACKGROUND: Although school screenings identify children with vision problems and issue referrals for medical treatment at an ophthalmic hospital, the effectiveness of this approach remains unverified.
OBJECTIVE: To investigate the impact of ophthalmic clinical services on the onset and progression of myopia in preschool children identified with vision impairment.
METHODS: Using data from the Shanghai Child and Adolescent Large-scale Eye Study (SCALE), this retrospective cohort study evaluated the visual development of children from three districts-Jing\'an, Minhang, and Pudong-which are representative of geographic diversity and economic disparity in Shanghai\'s 17 districts. Initially, in 2015, the study encompassed 14,572 children aged 4-6 years, of whom 5,917 needed a referral. Our cohort consisted of 5,511 children who had two or more vision screenings and complete personal information over the follow-up period from January 2015 to December 2020. We divided these children into two groups based on their initial spherical equivalent (SE): a High-risk group (SE > -0.5 D) and a Myopia group (SE ≤ -0.5 D). Within each of these groups, we further categorized children into Never, Tardily, and Timely groups based on their referral compliance to compare the differences in the occurrence and progression of myopia. Cox proportional models were applied to estimate hazard ratios (HRs) for myopia incidence per person-years of follow-up in High-risk group. Generalized additive models(GAM) was used to calculating the progression for annual spherical equivalent changes in all children.
RESULTS: Of the 5,511 preschool children (mean age, 5.25 years; 52.24% male) who received a referral recommendation, 1,327 (24.08%) sought clinical services at an ophthalmic hospital. After six years of follow-up, 65.53% of children developed myopia. The six-year cumulative incidence of myopia in the Never, Tardily, and Timely groups was 64.76%, 69.31%, and 57.14%, respectively. These percentages corresponded to hazard ratios (HRs) of 1.31 (95% CI, 1.10-1.55) for the Tardily group and 0.55 (95% CI, 0.33-0.93) for the Timely group, compared with the Never group. The HRs were adjusted for age, sex, and SE at study entry. Interestingly, the Timely group showed significantly less SE progression than the other groups (P < 0.001), and SE progression was higher in the High-risk group (-0.33 ± 0.37D/year) than in children with myopia (-0.08 ± 0.55D/year).
CONCLUSIONS: Timely utilization of ophthalmic clinical services among children aged 4 to 6 years who fail school vision screenings can significantly reduce the incidence of myopia and slow SE progression.