目的:探讨放射性碘(RAI)治疗分化型甲状腺癌(DTC)对男性性腺功能的影响。
方法:PubMed,Embase,WebofScience,OVID,Scopus,和万方数据库搜索到2022年6月10日,以确定已发表的与RAI和男性性腺功能相关的研究。使用ReviewManager版本5.41软件以95%置信区间(CI)计算平均差(MD)。
结果:最初,从数据库中检索到1958年的文章,共纳入6篇文献进行定量分析。Meta分析结果显示,RAI后随访时间≥12个月时,卵泡刺激素(FSH)升高,但差异无统计学意义[MD=-2.64,95%CI(-5.61,0.33),P=0.08]。但亚组分析结果显示,当随访时间≤6个月时,RAI后FSH水平显著升高[MD=-7.65,95%CI(-13.95,-1.34),P=0.02]。抑制素B水平在RAI后≥12个月和≤6个月时显著降低[MD=66.38,95%CI(8.39,124.37),P=0.02]和[MD=116.27,95%CI(43.56,188.98),P=0.002]。此外,黄体生成素(LH)和睾酮(T)具有相似的结果-即,LH和T水平在RAI后较高,但差异无统计学意义[MD=-0.87,95%CI(-2.04,0.30),P=0.15]和[MD=-1.69,95%CI(-7.29,3.90),P=0.55]。
结论:男性性腺功能可能在RAI后6个月内暂时受损,但之后可能会恢复到正常水平。
UNASSIGNED: The aim was to investigate the effect of radioactive iodine (RAI) treatment for differentiated thyroid cancer (DTC) on male gonadal function.
UNASSIGNED: PubMed, Embase, Web of Science, OVID, Scopus, and Wanfang databases were searched up to June 10, 2022, to identify published studies related to RAI and male gonadal function. ReviewManager version 5.4.1 software was used to calculate mean differences (MDs) with 95% CIs.
UNASSIGNED: Initially, 1958 articles were retrieved from the databases, and 6 articles were included in the quantitative analysis. The meta-analysis results showed that follicle-stimulating hormone (FSH) increased when the follow-up duration was ≥12 months after RAI, but the difference was not statistically significant (MD = -2.64, 95% CI = (-5.61, 0.33), P = 0.08). But the results of the subgroup analysis showed that when the follow-up time was ≤6 months, FSH levels were significantly higher after RAI (MD = -7.65, 95% CI = (-13.95, -1.34), P = 0.02). The level of inhibin B was significantly lower at ≥12 months and ≤6 months after RAI (MD = 66.38, 95% CI = (8.39, 124.37), P = 0.02) and (MD = 116.27, 95% CI = (43.56, 188.98), P = 0.002). Additionally, luteinizing hormone (LH) and testosterone have similar results - that is, LH and testosterone levels were higher after RAI, but the difference was not statistically significant (MD = -0.87, 95% CI = (-2.04, 0.30), P = 0.15) and (MD = -1.69, 95% CI (-7.29, 3.90), P = 0.55).
UNASSIGNED: Male gonadal function may be temporarily impaired within 6 months after RAI but may return to normal levels afterward.