HIV暴露后预防(PEP)是一种基于证据的生物医学HIV预防策略,包括在最近可能暴露于HIV后进行为期28天的高效抗逆转录病毒治疗。然而,男男性行为者(MSM)对PEP的认识和吸收非常低。需要创新和有效的方法来支持MSM中的PEP实施。这项工作报告了一个协议,用于设计和评估中国MSM中基于在线到离线的HIVPEP摄取(O2O-PEP)的交付模型。
这将是一个两阶段的研究。在第1阶段,我们将开发通过微信迷你应用程序(微信平台内置的应用程序)交付的O2O-PEP模型。O2O-PEP模式最初包括四个核心组成部分:基于游戏化的PEP教育包,在线艾滋病毒风险评估工具,PEP启动的免费在线预订系统,和研究医院的离线PEP处方。在第2阶段,将设计一项双臂试点分层随机对照试验,将O2O-PEP组与标准护理组进行比较,以评估可行性,可用性,以及O2O-PEP模型在增加中国MSM中PEP摄取方面的功效的初步证据。将进一步探索模型的可行性和可用性,以实现更广泛的模型。
O2O-PEP模式是中国首批旨在促进中国MSM启动PEP的干预措施之一。O2O-PEP模型中的成分可以帮助MSM更好地了解其HIV感染风险并增加PEP的可及性。此外,加上线上线下招聘,O2O-PEP模式具有很大的潜力,可以通过传统方法接触和吸引未参与护理的MSM。
没有。ChiCTR2200062538。
HIV post-exposure prophylaxis (PEP) is an evidence-based biomedical HIV prevention strategy consisting of a 28-day course of highly active antiretroviral therapy after recent potential exposure to HIV. However, awareness and uptake of PEP among men who have sex with men (MSM) are very low. Innovative and effective methods are needed to support PEP implementation among MSM. This work reports a protocol to design and evaluate an online-to-offline-based delivery model for HIV PEP uptake (O2O-PEP) in Chinese MSM.
This will be a two-phase study. In phase 1, we will develop an O2O-PEP model delivered through the WeChat mini-app (an app built into the WeChat platform). The O2O-PEP model initially includes four core components: a gamification-based education package for PEP, an online HIV risk assessment tool, a free online booking system for PEP initiation, and offline PEP prescription in the study hospitals. In phase 2, a two-arm pilot stratified randomized controlled trial comparing the O2O-PEP group with the standard care group will be designed to assess the feasibility, usability, and preliminary evidence of the efficacy of the O2O-PEP model in increasing PEP uptake among Chinese MSM. Model feasibility and usability will be further explored for broader model implementation.
The O2O-PEP model is one of the first interventions in
China aiming to promote PEP initiation in Chinese MSM. Components in the O2O-PEP model could assist MSM in better understanding their HIV infection risk and increasing accessibility of PEP. Moreover, coupled with online and offline recruitment, the O2O-PEP model has great potential to reach and engage MSM who are not involved in care by traditional methods.
No. ChiCTR2200062538.