目的:探讨单侧先天性白内障(CC)合并持续性胎儿血管(PFV)患者的眼部发育情况。
方法:这个横截面,观察性研究纳入了单侧CC和PFV患者以及孤立的单侧CC患者.轴向长度(AL),角膜曲率测量,前房深度(ACD),透镜厚度,获得玻璃体长度。将CC和PFV患者的受影响眼睛的眼睛生物特征参数与同侧眼睛和孤立CC患者的受影响眼睛进行比较。
结果:共纳入110例患者,分为4组:第1组(CC和PFV患者18例,<24个月),第2组(22例CC和PFV,≥24mo),第3组(35例CC患者,<24个月),和第4组(35例CC患者,≥24mo)。受累眼的AL比第1组的同侧眼短(20.02±1.06vs20.66±0.63mm,P=0.025)。在第2组中,受影响的眼睛的AL比其他眼睛的AL长(23.18±2.00vs22.31±1.06mm,P=0.044)和第4组(22.64±1.80vs22.02±1.01mm,P=0.033)。受影响的眼睛的角膜角化比第2组的其他眼睛更陡(44.78±1.66vs43.83±1.38D,P=0.041)和第4组(43.76±1.91vs43.34±1.46D,P=0.043)。各组双眼ACDs差异无统计学意义(均P>0.05)。
结论:与同伴的眼睛相比,单侧CC和PFV眼的AL在小于24mo的患者中较短,在大于24mo的患者中较长;单侧CC和PFV眼的角膜曲率在大于24mo的患者中较陡,与小于24mo的患者相似.这些发现为CC和PFV患者的眼部发育提供了进一步的理解。
OBJECTIVE: To investigate the ocular development of patients who had unilateral congenital cataract (CC) combined with persistent fetal vasculature (PFV).
METHODS: This cross-sectional, observational study included patients who had unilateral CC and PFV and those with isolated unilateral CC. Axial length (AL), keratometry, anterior chamber depth (ACD), lens thickness, and vitreous length were obtained. The ocular biometric parameters of the affected eyes of patients with CC and PFV were compared with the fellow eyes and with the affected eyes of patients with isolated CC.
RESULTS: A total of 110 patients were included and divided into 4 groups: group 1 (18 patients with CC and PFV, <24mo), group 2 (22 patients with CC and PFV, ≥24mo), group 3 (35 patients with CC, <24mo), and group 4 (35 patients with CC, ≥24mo). The ALs of the affected eyes were shorter than those of the fellow eyes in group 1 (20.02±1.06 vs 20.66±0.63 mm, P=0.025). While the ALs of the affected eyes were longer than those of the fellow eyes in group 2 (23.18±2.00 vs 22.31±1.06 mm, P=0.044) and group 4 (22.64±1.80 vs 22.02±1.01 mm, P=0.033). The keratometries of the affected eyes were steeper than those of the fellow eyes in group 2 (44.78±1.66 vs 43.83±1.38 D, P=0.041) and group 4 (43.76±1.91 vs 43.34±1.46 D, P=0.043). No difference of ACDs between two eyes was found in all groups (all P>0.05).
CONCLUSIONS: Compared with the fellow eyes, the ALs of the eyes with unilateral CC and PFV are shorter in patients younger than 24mo and longer in those older than 24mo; the keratometries of the eyes with unilateral CC and PFV are steeper in patients older than 24mo and similar with those younger than 24mo. These findings provide further understanding of ocular development in patients with both CC and PFV.